ENSMUSG00000025358


Mus musculus

Features
Gene ID: ENSMUSG00000025358
  
Biological name :Cdk2
  
Synonyms : Cdk2 / Cyclin-dependent kinase 2 / P97377
  
Possible biological names infered from orthology : P24941
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D3
Gene start: 128697939
Gene end: 128705031
  
Corresponding Affymetrix probe sets: 10373530 (MoGene1.0st)   1416873_a_at (Mouse Genome 430 2.0 Array)   1447617_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026415
Ensembl peptide - ENSMUSP00000026416
NCBI entrez gene - 12566     See in Manteia.
MGI - MGI:104772
RefSeq - XM_011243321
RefSeq - NM_016756
RefSeq - NM_183417
RefSeq - XM_006513162
RefSeq Peptide - NP_058036
RefSeq Peptide - NP_904326
swissprot - P97377
swissprot - Q3U6X7
swissprot - Q3UGB9
Ensembl - ENSMUSG00000025358
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk2ENSDARG00000026577Danio rerio
 CDK2ENSGALG00000032699Gallus gallus
 CDK2ENSG00000123374Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdk3-ps / cyclin dependent kinase 3 / CDK3* / Q00526*ENSMUSG0000009230063
Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*ENSMUSG0000001994255
Cdk5 / P49615 / Cyclin-dependent-like kinase 5 / Q00535* / cyclin dependent kinase 5*ENSMUSG0000002896951
Cdk6 / Q64261 / Cyclin-dependent kinase 6 / Q00534*ENSMUSG0000004027441
Cdk11b / P24788 / Mus musculus cyclin-dependent kinase 11B (Cdk11b), transcript variant 3, mRNA. / Q9UQ88* / CDK11A* / cyclin dependent kinase 11A* / cyclin dependent kinase 11B*ENSMUSG0000002906238
Cdk4 / P30285 / Cyclin-dependent kinase 4 / P11802*ENSMUSG0000000672838
Cdk10 / Q3UMM4 / Cyclin-dependent kinase 10 / Q15131*ENSMUSG0000003386237
E030030I06RikENSMUSG0000009732712


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IDA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0006813 potassium ion transport IGI
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007099 centriole replication IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010033 response to organic substance IBA
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016572 histone phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0032298 positive regulation of DNA-dependent DNA replication initiation IGI
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IGI
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0060968 regulation of gene silencing IEA
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IEA
 cellular_componentGO:0000781 chromosome, telomeric region IDA
 cellular_componentGO:0000793 condensed chromosome IDA
 cellular_componentGO:0000805 X chromosome IDA
 cellular_componentGO:0000806 Y chromosome IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0015030 Cajal body IEA
 cellular_componentGO:0097123 cyclin A1-CDK2 complex IDA
 cellular_componentGO:0097124 cyclin A2-CDK2 complex IEA
 cellular_componentGO:0097134 cyclin E1-CDK2 complex IDA
 cellular_componentGO:0097135 cyclin E2-CDK2 complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030332 cyclin binding IEA
 molecular_functionGO:0035173 histone kinase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0097472 cyclin-dependent protein kinase activity IEA


Pathways (from Reactome)
Pathway description
G0 and Early G1
Activation of ATR in response to replication stress
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
Activation of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
Cyclin A/B1/B2 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
PTK6 Regulates Cell Cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Cdk2tm1.1Jro/Cdk2tm1.1Jro
Genetic Background: involves: 129S1/SvlmJ * 129S4/SvJaeSor * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Cdk2tm2Sgo/Cdk2tm2Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd,Polr2atm1(cre/ERT2)Bbd/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001627 abnormal cardiac output "anomaly in the blood volume pumped by each ventricle per minute (stroke volume x heart rate)" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Cdk2tm1.1Jro/Cdk2tm1.1Jro
Genetic Background: involves: 129S1/SvlmJ * 129S4/SvJaeSor * C57BL/6

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001930 abnormal meiosis "malfunction in the process of nuclear division that results in gametes with one half the normal number of the original cell" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0001931 abnormal oogenesis "atypical formation or failure to form the female germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Foxj1tm1Slb/Foxj1tm1Slb
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdk2tm2Sgo/Cdk2tm2Sgo,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atoh1tm1(cre)Gan/Atoh1tm1(cre)Gan
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cdk2tm1.1Jro/Cdk2+
Genetic Background: involves: 129S1/SvlmJ * 129S4/SvJaeSor * C57BL/6

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004001 decreased hepatocyte proliferation "reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0004567 decreased myocardial fiber number "decreased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk2tm2Sgo/Cdk2tm2Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd,Polr2atm1(cre/ERT2)Bbd/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004805 absent oocytes "absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004833 ovary atrophy "wasting of the ovary due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccne2tm1Pisc/Ccne2tm1Pisc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004894 uterus atrophy "wasting of the uterus due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdk2tm1.1Jro/Cdk2+
Genetic Background: involves: 129S1/SvlmJ * 129S4/SvJaeSor * C57BL/6

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk1tm1(Cdk2)Kald/Cdk1+,Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv

 MP:0008725 enlarged heart atrium "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cdk2tm1.1Jro/Cdk2tm1.1Jro
Genetic Background: involves: 129S1/SvlmJ * 129S4/SvJaeSor * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / complex / reaction
 ENSMUSG00000027490 E2f1 / Q61501 / Transcription factor E2F1 / Q01094* / E2F transcription factor 1*  / reaction / complex
 ENSMUSG00000003031 Cdkn1b / P46414 / Cyclin-dependent kinase inhibitor 1B / P46527*  / complex / reaction
 ENSMUSG00000014859 E2f4 / Q8R0K9 / Transcription factor E2F4 / Q16254* / E2F transcription factor 4*  / reaction / complex
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / complex / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / complex / reaction
 ENSMUSG00000022105 Rb1 / P13405 / Retinoblastoma-associated protein / P06400* / RB transcriptional corepressor 1*  / complex / reaction
 ENSMUSG00000028212 Ccne2 / Q9Z238 / G1/S-specific cyclin-E2 / O96020* / cyclin E2*  / reaction / complex
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction
 ENSMUSG00000040957 Q9ESJ1 / Cables1 / CDK5 and ABL1 enzyme substrate 1 / Q8TDN4* / Cdk5 and Abl enzyme substrate 1*  / complex / reaction
 ENSMUSG00000042489 Clspn / Q80YR7 / Claspin / Q9HAW4*  / reaction / complex
 ENSMUSG00000031016 Wee1 / P47810 / WEE 1 homolog 1 (S. pombe) / P30291* / WEE1 G2 checkpoint kinase*  / reaction / complex
 ENSMUSG00000016477 E2f3 / O35261 / Transcription factor E2F3 / O00716* / E2F transcription factor 3*  / complex / reaction
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / complex / reaction
 ENSMUSG00000020235 Fzr1 / Q9R1K5 / Fizzy-related protein homolog / Q9UM11* / fizzy and cell division cycle 20 related 1*  / complex / reaction
 ENSMUSG00000026669 Mcm10 / Q0VBD2 / minichromosome maintenance 10 replication initiation factor / Q7L590*  / complex / reaction
 ENSMUSG00000000028 Cdc45 / Q9Z1X9 / Cell division control / O75419* / cell division cycle 45*  / reaction / complex
 ENSMUSG00000020184 Mdm2 / P23804 / E3 ubiquitin-protein ligase Mdm2 / Q00987* / MDM2 proto-oncogene*  / reaction
 ENSMUSG00000006585 Cdt1 / Q8R4E9 / DNA replication factor Cdt1 / Q9H211* / chromatin licensing and DNA replication factor 1*  / reaction
 ENSMUSG00000023067 Cdkn1a / P39689 / Cyclin-dependent kinase inhibitor 1 / P38936* / cyclin dependent kinase inhibitor 1A*  / complex / reaction
 ENSMUSG00000027641 Rbl1 / Q64701 / Retinoblastoma-like protein 1 / P28749* / RB transcriptional corepressor like 1*  / complex / reaction
 ENSMUSG00000041238 Rbbp8 / Q80YR6 / retinoblastoma binding protein 8, endonuclease / Q99708* / RB binding protein 8, endonuclease*  / complex / reaction
 ENSMUSG00000002297 A / Dbf4 / Q9QZ41 / Q9UBU7* / DBF4 zinc finger*  / complex / reaction
 ENSMUSG00000029283 Cdc7 / Q9Z0H0 / Cell division cycle 7-related protein kinase / O00311* / cell division cycle 7*  / complex / reaction
 ENSMUSG00000017499 Cdc6 / O89033 / Cell division control / Q99741* / cell division cycle 6*  / complex / reaction
 ENSMUSG00000002068 Ccne1 / Q61457 / G1/S-specific cyclin-E1 / P24864* / cyclin E1*  / reaction / complex
 ENSMUSG00000021103 Mnat1 / P51949 / CDK-activating kinase assembly factor MAT1 / P51948* / MNAT1, CDK activating kinase assembly factor*  / reaction
 ENSMUSG00000021548 Ccnh / Q61458 / Cyclin-H / P51946*  / reaction
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / reaction / complex
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / complex / reaction
 ENSMUSG00000027552 E2f5 / Q61502 / Transcription factor E2F5 / Q15329* / E2F transcription factor 5*  / reaction / complex
 ENSMUSG00000032409 Atr / ATR serine/threonine kinase / Q13535*  / reaction
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / reaction / complex
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction / complex
 ENSMUSG00000031666 Rbl2 / Q64700 / Retinoblastoma-like protein 2 / Q08999* / RB transcriptional corepressor like 2*  / complex / reaction
 ENSMUSG00000062687 Cks1brt / CDC28 protein kinase 1b, retrogene / CKS1B* / P61024* / CDC28 protein kinase regulatory subunit 1B*  / complex / reaction
 ENSMUSG00000054115 Skp2 / Q9Z0Z3 / S-phase kinase-associated protein 2 (p45) / Q13309* / S-phase kinase associated protein 2*  / complex / reaction
 ENSMUSG00000069089 Cdk7 / Q03147 / Cyclin-dependent kinase 7 / P50613*  / reaction
 ENSMUSG00000032477 Cdc25a / P48964 / M-phase inducer phosphatase 1 / P30304* / cell division cycle 25A*  / reaction
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction / complex
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / reaction / complex
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / reaction / complex






 

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