ENSMUSG00000042489


Mus musculus

Features
Gene ID: ENSMUSG00000042489
  
Biological name :Clspn
  
Synonyms : Claspin / Clspn / Q80YR7
  
Possible biological names infered from orthology : Q9HAW4
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.2
Gene start: 126556935
Gene end: 126593903
  
Corresponding Affymetrix probe sets: 10508151 (MoGene1.0st)   1441984_at (Mouse Genome 430 2.0 Array)   1456280_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120683
Ensembl peptide - ENSMUSP00000045344
Ensembl peptide - ENSMUSP00000116699
Ensembl peptide - ENSMUSP00000119437
NCBI entrez gene - 269582     See in Manteia.
MGI - MGI:2445153
RefSeq - XM_011240541
RefSeq - XM_006503122
RefSeq - XM_006503123
RefSeq - XM_006503124
RefSeq - XM_006503125
RefSeq - XM_011240540
RefSeq - NM_175554
RefSeq Peptide - NP_780763
swissprot - F6S522
swissprot - B1ARX7
swissprot - B1ARX5
swissprot - Q80YR7
Ensembl - ENSMUSG00000042489
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CLSPNENSGALG00000002346Gallus gallus
 CLSPNENSG00000092853Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024146  Claspin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000076 DNA replication checkpoint ISO
 biological_processGO:0000077 DNA damage checkpoint IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0033314 mitotic DNA replication checkpoint IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 molecular_functionGO:0000217 DNA secondary structure binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0010997 anaphase-promoting complex binding IEA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
Activation of ATR in response to replication stress
Ub-specific processing proteases
Processing of DNA double-strand break ends


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000028 Cdc45 / Q9Z1X9 / Cell division control / O75419* / cell division cycle 45*  / reaction / complex
 ENSMUSG00000002297 A / Dbf4 / Q9QZ41 / Q9UBU7* / DBF4 zinc finger*  / complex / reaction
 ENSMUSG00000025076 Casp7 / P97864 / Caspase-7 Caspase-7 subunit p20 Caspase-7 subunit p11 / P55210* / caspase 7*  / reaction
 ENSMUSG00000026669 Mcm10 / Q0VBD2 / minichromosome maintenance 10 replication initiation factor / Q7L590*  / complex / reaction
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / complex / reaction
 ENSMUSG00000032409 Atr / ATR serine/threonine kinase / Q13535*  / reaction
 ENSMUSG00000032113 Chek1 / O35280 / Serine/threonine-protein kinase Chk1 / O14757* / checkpoint kinase 1*  / reaction
 ENSMUSG00000032397 Tipin / Q91WA1 / TIMELESS-interacting protein / Q9BVW5*  / reaction
 ENSMUSG00000029283 Cdc7 / Q9Z0H0 / Cell division cycle 7-related protein kinase / O00311* / cell division cycle 7*  / complex / reaction
 ENSMUSG00000017499 Cdc6 / O89033 / Cell division control / Q99741* / cell division cycle 6*  / complex / reaction
 ENSMUSG00000032267 Usp28 / Q5I043 / ubiquitin specific peptidase 28 / Q96RU2*  / complex
 ENSMUSG00000039994 Q9R1X4 / Timeless / timeless circadian regulator / Q9UNS1*  / reaction






 

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