ENSMUSG00000039994


Mus musculus

Features
Gene ID: ENSMUSG00000039994
  
Biological name :Timeless
  
Synonyms : Q9R1X4 / Timeless / timeless circadian regulator
  
Possible biological names infered from orthology : Q9UNS1
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D3
Gene start: 128232065
Gene end: 128252941
  
Corresponding Affymetrix probe sets: 10367179 (MoGene1.0st)   1417586_at (Mouse Genome 430 2.0 Array)   1417587_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132079
Ensembl peptide - ENSMUSP00000100878
Ensembl peptide - ENSMUSP00000100879
Ensembl peptide - ENSMUSP00000058021
Ensembl peptide - ENSMUSP00000100876
Ensembl peptide - ENSMUSP00000100877
NCBI entrez gene - 21853     See in Manteia.
MGI - MGI:1321393
RefSeq - XM_006513583
RefSeq - NM_001136082
RefSeq - NM_001164080
RefSeq - NM_001164081
RefSeq - NM_011589
RefSeq - XM_006513580
RefSeq - XM_006513581
RefSeq - XM_006513582
RefSeq Peptide - NP_001157553
RefSeq Peptide - NP_035719
RefSeq Peptide - NP_001129554
RefSeq Peptide - NP_001157552
swissprot - Q9R1X4
swissprot - H7BX89
swissprot - E9Q302
swissprot - Q3U574
Ensembl - ENSMUSG00000039994
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 timelessENSDARG00000078497Danio rerio
 ENSGALG00000034688Gallus gallus
 ENSGALG00000036572Gallus gallus
 Q9UNS1ENSG00000111602Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006906  Timeless protein
 IPR007725  Timeless C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis ISO
 biological_processGO:0002009 morphogenesis of an epithelium IEP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007623 circadian rhythm IEP
 biological_processGO:0030324 lung development IMP
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0044770 cell cycle phase transition ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0072711 cellular response to hydroxyurea ISO
 biological_processGO:0072719 cellular response to cisplatin ISS
 biological_processGO:1904976 cellular response to bleomycin ISO
 biological_processGO:2000781 positive regulation of double-strand break repair ISS
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
Processing of DNA double-strand break ends


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu
Genetic Background: involves: OF1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032113 Chek1 / O35280 / Serine/threonine-protein kinase Chk1 / O14757* / checkpoint kinase 1*  / reaction
 ENSMUSG00000032397 Tipin / Q91WA1 / TIMELESS-interacting protein / Q9BVW5*  / complex
 ENSMUSG00000042489 Clspn / Q80YR7 / Claspin / Q9HAW4*  / reaction






 

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