ENSG00000111602


Homo sapiens

Features
Gene ID: ENSG00000111602
  
Biological name :TIMELESS
  
Synonyms : Q9UNS1 / TIMELESS / timeless circadian regulator
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.3
Gene start: 56416373
Gene end: 56449403
  
Corresponding Affymetrix probe sets: 203046_s_at (Human Genome U133 Plus 2.0 Array)   215455_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000229201
Ensembl peptide - ENSP00000450607
NCBI entrez gene - 8914     See in Manteia.
OMIM - 603887
RefSeq - XM_011538939
RefSeq - NM_001330295
RefSeq - NM_003920
RefSeq Peptide - NP_003911
RefSeq Peptide - NP_001317224
swissprot - Q9UNS1
Ensembl - ENSG00000111602
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 timelessENSDARG00000078497Danio rerio
 ENSGALG00000034688Gallus gallus
 ENSGALG00000036572Gallus gallus
 Q9R1X4ENSMUSG00000039994Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006906  Timeless protein
 IPR007725  Timeless C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0002009 morphogenesis of an epithelium ISS
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0009582 detection of abiotic stimulus TAS
 biological_processGO:0030324 lung development IEA
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0044770 cell cycle phase transition IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0072711 cellular response to hydroxyurea IMP
 biological_processGO:0072719 cellular response to cisplatin IMP
 biological_processGO:1904976 cellular response to bleomycin IMP
 biological_processGO:2000781 positive regulation of double-strand break repair IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Processing of DNA double-strand break ends


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000149554 CHEK1 / O14757 / checkpoint kinase 1  / reaction
 ENSG00000092853 CLSPN / Q9HAW4 / claspin  / reaction
 ENSG00000075131 TIPIN / Q9BVW5 / TIMELESS interacting protein  / complex






 

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