ENSG00000149554


Homo sapiens

Features
Gene ID: ENSG00000149554
  
Biological name :CHEK1
  
Synonyms : checkpoint kinase 1 / CHEK1 / O14757
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q24.2
Gene start: 125625136
Gene end: 125676255
  
Corresponding Affymetrix probe sets: 205393_s_at (Human Genome U133 Plus 2.0 Array)   205394_at (Human Genome U133 Plus 2.0 Array)   229423_at (Human Genome U133 Plus 2.0 Array)   238075_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481616
Ensembl peptide - ENSP00000431525
Ensembl peptide - ENSP00000431815
Ensembl peptide - ENSP00000432470
Ensembl peptide - ENSP00000432890
Ensembl peptide - ENSP00000433103
Ensembl peptide - ENSP00000434141
Ensembl peptide - ENSP00000434646
Ensembl peptide - ENSP00000435371
Ensembl peptide - ENSP00000442317
Ensembl peptide - ENSP00000477588
Ensembl peptide - ENSP00000481614
Ensembl peptide - ENSP00000278916
Ensembl peptide - ENSP00000388648
Ensembl peptide - ENSP00000391090
Ensembl peptide - ENSP00000412504
NCBI entrez gene - 1111     See in Manteia.
OMIM - 603078
RefSeq - XM_011542563
RefSeq - XM_011542562
RefSeq - XM_011542561
RefSeq - XM_011542560
RefSeq - NM_001274
RefSeq - NM_001244846
RefSeq - NM_001114122
RefSeq - NM_001114121
RefSeq - XM_017017146
RefSeq Peptide - NP_001107594
RefSeq Peptide - NP_001107593
RefSeq Peptide - NP_001231775
RefSeq Peptide - NP_001265
RefSeq Peptide - NP_001317356
RefSeq Peptide - NP_001317357
swissprot - E9PM65
swissprot - E9PJI4
swissprot - E7EPP6
swissprot - A0A087WY91
swissprot - A0A087WT52
swissprot - O14757
swissprot - J3KN87
swissprot - E9PRU7
swissprot - E9PQW7
swissprot - E9PPA5
swissprot - E9PKQ3
Ensembl - ENSG00000149554
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chek1ENSDARG00000104765Danio rerio
 CHEK1ENSGALG00000042418Gallus gallus
 Chek1ENSMUSG00000032113Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SBK1 / Q52WX2 / SH3 domain binding kinase 1ENSG0000018832213
SBK3 / P0C264 / SH3 domain binding kinase family member 3ENSG0000023127412
SBK2 / P0C263 / SH3 domain binding kinase family member 2ENSG0000018755012


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR034670  Checkpoint kinase 1, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IMP
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IEA
 biological_processGO:0001833 inner cell mass cell proliferation IEA
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006281 DNA repair IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0006975 DNA damage induced protein phosphorylation IDA
 biological_processGO:0006997 nucleus organization IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007093 mitotic cell cycle checkpoint IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010569 regulation of double-strand break repair via homologous recombination IDA
 biological_processGO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IDA
 biological_processGO:0035407 histone H3-T11 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0045787 positive regulation of cell cycle IDA
 biological_processGO:0045839 negative regulation of mitotic nuclear division IDA
 biological_processGO:0046602 regulation of mitotic centrosome separation IDA
 biological_processGO:0048096 chromatin-mediated maintenance of transcription ISS
 biological_processGO:0070317 negative regulation of G0 to G1 transition TAS
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint IMP
 biological_processGO:0090399 replicative senescence NAS
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 biological_processGO:1902742 apoptotic process involved in development IEA
 biological_processGO:2000615 regulation of histone H3-K9 acetylation ISS
 cellular_componentGO:0000781 chromosome, telomeric region IDA
 cellular_componentGO:0000785 chromatin ISS
 cellular_componentGO:0000794 condensed nuclear chromosome IDA
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005657 replication fork IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IMP
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0035402 histone kinase activity (H3-T11 specific) IDA


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT
Activation of ATR in response to replication stress
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
TP53 Regulates Transcription of DNA Repair Genes
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000111602 Q9UNS1 / TIMELESS / timeless circadian regulator  / reaction
 ENSG00000092853 CLSPN / Q9HAW4 / claspin  / reaction
 ENSG00000075131 TIPIN / Q9BVW5 / TIMELESS interacting protein  / reaction
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / reaction
 ENSG00000164045 CDC25A / P30304 / cell division cycle 25A  / reaction
 ENSG00000157404 KIT / P10721 / KIT proto-oncogene receptor tyrosine kinase  / complex / reaction
 ENSG00000169016 E2F6 / O75461 / E2F transcription factor 6  / reaction
 ENSG00000049130 KITLG / P21583 / KIT ligand  / reaction / complex
 ENSG00000158402 CDC25C / P30307 / cell division cycle 25C  / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction
 ENSG00000051180 RAD51 / Q06609 / RAD51 recombinase  / reaction
 ENSG00000166483 WEE1 / P30291 / WEE1 G2 checkpoint kinase  / reaction
 ENSG00000139618 BRCA2 / P51587 / BRCA2, DNA repair associated  / reaction
 ENSG00000175054 ATR / Q13535 / ATR serine/threonine kinase  / reaction






 

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