ENSMUSG00000032113


Mus musculus

Features
Gene ID: ENSMUSG00000032113
  
Biological name :Chek1
  
Synonyms : Chek1 / O35280 / Serine/threonine-protein kinase Chk1
  
Possible biological names infered from orthology : checkpoint kinase 1 / O14757
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A4
Gene start: 36708482
Gene end: 36727065
  
Corresponding Affymetrix probe sets: 10592201 (MoGene1.0st)   1420031_at (Mouse Genome 430 2.0 Array)   1420032_at (Mouse Genome 430 2.0 Array)   1439208_at (Mouse Genome 430 2.0 Array)   1449708_s_at (Mouse Genome 430 2.0 Array)   1450677_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034625
Ensembl peptide - ENSMUSP00000133589
Ensembl peptide - ENSMUSP00000134029
Ensembl peptide - ENSMUSP00000134388
NCBI entrez gene - 12649     See in Manteia.
MGI - MGI:1202065
RefSeq - XM_017313117
RefSeq - NM_007691
RefSeq Peptide - NP_031717
swissprot - G3UX84
swissprot - O35280
swissprot - G3UYC5
Ensembl - ENSMUSG00000032113
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chek1ENSDARG00000104765Danio rerio
 CHEK1ENSGALG00000042418Gallus gallus
 CHEK1ENSG00000149554Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sbk2 / P0C5K1 / Serine/threonine-protein kinase SBK2 / P0C263* / SH3 domain binding kinase family member 2*ENSMUSG0000003043317
Sbk1 / Q8QZX0 / Serine/threonine-protein kinase SBK1 / Q52WX2* / SH3 domain binding kinase 1*ENSMUSG0000004297817
Sbk3 / P0C5K0 / Uncharacterized serine/threonine-protein kinase SBK3 / P0C264* / SH3 domain binding kinase family member 3*ENSMUSG0000008527215


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR034670  Checkpoint kinase 1, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IEA
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IMP
 biological_processGO:0001833 inner cell mass cell proliferation IMP
 biological_processGO:0006281 DNA repair ISO
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0006975 DNA damage induced protein phosphorylation ISO
 biological_processGO:0006997 nucleus organization IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007093 mitotic cell cycle checkpoint IMP
 biological_processGO:0010468 regulation of gene expression IGI
 biological_processGO:0010569 regulation of double-strand break repair via homologous recombination ISS
 biological_processGO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation ISS
 biological_processGO:0035407 histone H3-T11 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0045787 positive regulation of cell cycle ISO
 biological_processGO:0045839 negative regulation of mitotic nuclear division ISO
 biological_processGO:0046602 regulation of mitotic centrosome separation ISO
 biological_processGO:0048096 chromatin-mediated maintenance of transcription IMP
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint ISO
 biological_processGO:1902742 apoptotic process involved in development IMP
 biological_processGO:2000615 regulation of histone H3-K9 acetylation IDA
 cellular_componentGO:0000781 chromosome, telomeric region ISO
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0000794 condensed nuclear chromosome ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005657 replication fork IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0035402 histone kinase activity (H3-T11 specific) IDA


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT
Activation of ATR in response to replication stress
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Transcriptional Regulation by E2F6


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chek1tm1Jmr/Chek1tm1Jmr,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Chek1tm1Jmr/Chek1tm1Jmr,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: C57BL/6

 MP:0000627 abnormal mammary gland morphology "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]
Show

Allelic Composition: Pax3Sp-10J/Pax3Sp-10J
Genetic Background: C57BL/6J-Pax3Sp-10J/GrsrJ

Allelic Composition: Chek1tm2.1Sje/Chek1tm2.1Sje,Tg(MMTV-cre)#Mam/0
Genetic Background: involves: FVB

 MP:0000630 mammary gland hyperplasia "increased size of mammary gland due to increased cell number" [J:63229]
Show

Allelic Composition: Chek1tm2.1Sje/Chek1tm2.1Sje,Tg(MMTV-cre)#Mam/0
Genetic Background: involves: FVB

Allelic Composition: Chek1tm2.1Sje/Chek1+,Trp53tm1Brn/Trp53+,Tg(MMTV-cre)#Mam/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Chek1tm2.1Sje/Chek1+,Trp53tm1Brn/Trp53+,Tg(MMTV-cre)#Mam/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Htr1atm1Toth/Htr1a+
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
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Allelic Composition: Htr1atm1Toth/Htr1a+
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Chek1tm2.1Sje/Chek1+,Trp53tm1Brn/Trp53+,Tg(MMTV-cre)#Mam/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chek1tm2.1Sje/Chek1+,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)#Mam/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Chek1tm2.1Sje/Chek1tm2.1Sje,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)#Mam/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Chek1tm2.1Sje/Chek1tm2.1Sje,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)#Mam/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Chek1tm2.1Sje/Chek1+,Trp53tm1Brn/Trp53+,Tg(MMTV-cre)#Mam/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0003694 failure to hatch from the zona pellucida "the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chek1tm2.1Sje/Chek1+,Trp53tm1Brn/Trp53+,Tg(MMTV-cre)#Mam/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Chek1tm2.1Sje/Chek1+,Trp53tm1Brn/Trp53+,Tg(MMTV-cre)#Mam/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0004966 abnormal inner cell mass proliferation "any anomaly in the ability of the inner cell mass population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Chek1tm1Sje/Chek1tm1Sje,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Chek1tm1Jmr/Chek1tm1Jmr,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: C57BL/6

 MP:0009506 abnormal mammary gland alveolus morphology "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax3Sp-10J/Pax3Sp-10J
Genetic Background: C57BL/6J-Pax3Sp-10J/GrsrJ

Allelic Composition: Chek1tm2.1Sje/Chek1tm2.1Sje,Tg(MMTV-cre)#Mam/0
Genetic Background: involves: FVB

Allelic Composition: Chek1tm2.1Sje/Chek1+,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)#Mam/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Chek1tm2.1Sje/Chek1tm2.1Sje,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)#Mam/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Chek1tm2.1Sje/Chek1tm2.1Sje,Trp53tm1Brn/Trp53+,Tg(MMTV-cre)#Mam/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Chek1tm2.1Sje/Chek1+,Trp53tm1Brn/Trp53+,Tg(MMTV-cre)#Mam/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chek1tm2.1Sje/Chek1+,Trp53tm1Brn/Trp53+,Tg(MMTV-cre)#Mam/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chek1tm2.1Sje/Chek1+,Trp53tm1Brn/Trp53tm1Brn,Tg(MMTV-cre)#Mam/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Chek1tm2.1Sje/Chek1tm2.1Sje,Trp53tm1Brn/Trp53+,Tg(MMTV-cre)#Mam/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Chek1tm2.1Sje/Chek1+,Trp53tm1Brn/Trp53+,Tg(MMTV-cre)#Mam/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Chek1tm1Sje/Chek1tm1Sje,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / reaction / complex
 ENSMUSG00000032409 Atr / ATR serine/threonine kinase / Q13535*  / reaction
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction
 ENSMUSG00000039994 Q9R1X4 / Timeless / timeless circadian regulator / Q9UNS1*  / reaction
 ENSMUSG00000041147 Brca2 / P97929 / Breast cancer type 2 susceptibility protein homolog / P51587* / BRCA2, DNA repair associated*  / reaction
 ENSMUSG00000057469 E2f6 / O54917 / Transcription factor E2F6 / O75461* / E2F transcription factor 6*  / reaction
 ENSMUSG00000032477 Cdc25a / P48964 / M-phase inducer phosphatase 1 / P30304* / cell division cycle 25A*  / reaction
 ENSMUSG00000044201 Cdc25c / P48967 / cell division cycle 25C / P30307*  / reaction
 ENSMUSG00000042489 Clspn / Q80YR7 / Claspin / Q9HAW4*  / reaction
 ENSMUSG00000032397 Tipin / Q91WA1 / TIMELESS-interacting protein / Q9BVW5*  / reaction
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / reaction






 

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