ENSMUSG00000032477


Mus musculus

Features
Gene ID: ENSMUSG00000032477
  
Biological name :Cdc25a
  
Synonyms : Cdc25a / M-phase inducer phosphatase 1 / P48964
  
Possible biological names infered from orthology : cell division cycle 25A / P30304
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F2
Gene start: 109875579
Gene end: 109893895
  
Corresponding Affymetrix probe sets: 10589420 (MoGene1.0st)   1417131_at (Mouse Genome 430 2.0 Array)   1417132_at (Mouse Genome 430 2.0 Array)   1445995_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142819
Ensembl peptide - ENSMUSP00000142958
Ensembl peptide - ENSMUSP00000091882
Ensembl peptide - ENSMUSP00000142752
NCBI entrez gene - 12530     See in Manteia.
MGI - MGI:103198
RefSeq - XM_006511929
RefSeq - XM_006511930
RefSeq - XM_006511931
RefSeq - NM_007658
RefSeq Peptide - NP_031684
swissprot - P48964
swissprot - A0A0G2JEF5
swissprot - A0A0G2JEL7
swissprot - Q3UQK4
Ensembl - ENSMUSG00000032477
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc25bENSDARG00000010792Danio rerio
 CDC25AENSGALG00000038469Gallus gallus
 CDC25AENSG00000164045Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdc25b / P30306 / M-phase inducer phosphatase 2 / P30305* / cell division cycle 25B*ENSMUSG0000002733045
Cdc25c / P48967 / cell division cycle 25C / P30307*ENSMUSG0000004420127


Protein motifs (from Interpro)
Interpro ID Name
 IPR000751  M-phase inducer phosphatase
 IPR001763  Rhodanese-like domain
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:1902751 positive regulation of cell cycle G2/M phase transition IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0051087 chaperone binding IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Ub-specific processing proteases
Cyclin E associated events during G1/S transition
Cyclin A/B1/B2 associated events during G2/M transition
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Cyclin A:Cdk2-associated events at S phase entry


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Baxtm1Dlo/Baxtm1Dlo,Bcl2l1tm1Dlo/Bcl2l1tm1Dlo
Genetic Background: involves: 129P2/OlaHsd

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox17tm1Sjm/Sox17tm2Sjm,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C3H * C57BL/6 * C57BL/Ka * CBA

 MP:0000489 abnormal large intestine morphology "structural or developmental anomalies of the intestinum crassum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pink1tm1Hbu/Pink1tm1Hbu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pink1tm1Hbu/Pink1tm1Hbu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Pink1tm1Hbu/Pink1tm1Hbu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
Show

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002053 decreased incidence of induced tumors "reduced frequency of tumor incidence induced by a carcinogen or mutagen" [J:56886]
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Allelic Composition: Sox17tm1Sjm/Sox17tm2Sjm,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C3H * C57BL/6 * C57BL/Ka * CBA

Allelic Composition: Cdc25atm1Kiyo/Cdc25a+,Tg(MMTV-Erbb2)NK1Mul/?
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdc25atm1.1Hpw/Cdc25atm1.1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdc25atm1.1Hpw/Cdc25atm1.1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pax1Un-s/Pax1Un-s
Genetic Background: B6.CC57BR-Pax1Un-s

 MP:0003693 abnormal embryo hatching "anomalies in the ability of the embryo to break out of the zona pellucida, the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox17tm1Sjm/Sox17tm2Sjm,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C3H * C57BL/6 * C57BL/Ka * CBA

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax1Un-s/Pax1Un-s
Genetic Background: B6.CC57BR-Pax1Un-s

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004500 increased incidence of ionizing radiation-induced tumors "higher than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tph1tm2Lex/Tph1tm2Lex,Tph2tm1Lex/Tph2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax1Un-s/Pax1Un-s
Genetic Background: B6.CC57BR-Pax1Un-s

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0008142 decreased small intestinal villus size "reduced size of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008885 increased enterocyte apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0010157 abnormal small intestinal crypt cell proliferation "anomaly in the ability of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine to undergo expansion by cell division" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0010159 abnormal enterocyte differentiation "abnormal formation of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Sox17tm1Sjm/Sox17tm2Sjm,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C3H * C57BL/6 * C57BL/Ka * CBA

Allelic Composition: Cdc25atm1.1Hpw/Cdc25atm1.1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Baxtm1Dlo/Baxtm1Dlo,Bcl2l1tm1Dlo/Bcl2l1tm1Dlo
Genetic Background: involves: 129P2/OlaHsd

 MP:0013958 decreased small intestine length "reduced length of the portion of the digestive tube between the stomach and the cecum, consisting of the duodenum, ileum and jejunum" [ISBN:0683400088]
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Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0014082 decreased small intestinal villus height "decreased height of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; usually accompanied by crypt elongation or hyperplasia" [MGI:Anna, PMID:16679353]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032113 Chek1 / O35280 / Serine/threonine-protein kinase Chk1 / O14757* / checkpoint kinase 1*  / reaction
 ENSMUSG00000029521 Chek2 / Q9Z265 / Serine/threonine-protein kinase Chk2 / O96017* / checkpoint kinase 2*  / reaction
 ENSMUSG00000019942 Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*  / reaction
 ENSMUSG00000041431 Ccnb1 / P24860 / G2/mitotic-specific cyclin-B1 / P14635* / cyclin B1*  / reaction
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / reaction
 ENSMUSG00000028212 Ccne2 / Q9Z238 / G1/S-specific cyclin-E2 / O96020* / cyclin E2*  / reaction
 ENSMUSG00000002068 Ccne1 / Q61457 / G1/S-specific cyclin-E1 / P24864* / cyclin E1*  / reaction






 

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