ENSMUSG00000044201


Mus musculus

Features
Gene ID: ENSMUSG00000044201
  
Biological name :Cdc25c
  
Synonyms : Cdc25c / cell division cycle 25C / P48967
  
Possible biological names infered from orthology : P30307
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B1
Gene start: 34732997
Gene end: 34751533
  
Corresponding Affymetrix probe sets: 10458195 (MoGene1.0st)   1422252_a_at (Mouse Genome 430 2.0 Array)   1456077_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000055427
NCBI entrez gene - 12532     See in Manteia.
MGI - MGI:88350
RefSeq - XM_006525551
RefSeq - NM_009860
RefSeq Peptide - NP_033990
swissprot - P48967
swissprot - Q3UR74
Ensembl - ENSMUSG00000044201
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDC25CENSG00000158402Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdc25b / P30306 / M-phase inducer phosphatase 2 / P30305* / cell division cycle 25B*ENSMUSG0000002733034
Cdc25a / P48964 / M-phase inducer phosphatase 1 / P30304* / cell division cycle 25A*ENSMUSG0000003247731


Protein motifs (from Interpro)
Interpro ID Name
 IPR000751  M-phase inducer phosphatase
 IPR001763  Rhodanese-like domain
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:1902751 positive regulation of cell cycle G2/M phase transition IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0050699 WW domain binding IEA


Pathways (from Reactome)
Pathway description
Polo-like kinase mediated events
Activation of ATR in response to replication stress
RHO GTPases activate PKNs
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Cyclin A/B1/B2 associated events during G2/M transition
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000489 abnormal large intestine morphology "structural or developmental anomalies of the intestinum crassum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdc25atm1.1Hpw/Cdc25atm1.1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0008142 decreased small intestinal villus size "reduced size of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008885 increased enterocyte apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0010157 abnormal small intestinal crypt cell proliferation "anomaly in the ability of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine to undergo expansion by cell division" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0010159 abnormal enterocyte differentiation "abnormal formation of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0013958 decreased small intestine length "reduced length of the portion of the digestive tube between the stomach and the cecum, consisting of the duodenum, ileum and jejunum" [ISBN:0683400088]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0014082 decreased small intestinal villus height "decreased height of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; usually accompanied by crypt elongation or hyperplasia" [MGI:Anna, PMID:16679353]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000057672 Pkn1 / P70268 / Serine/threonine-protein kinase N1 / Q16512* / protein kinase N1*  / reaction / complex
 ENSMUSG00000030867 Plk1 / Q07832 / polo like kinase 1 / P53350*  / reaction
 ENSMUSG00000032113 Chek1 / O35280 / Serine/threonine-protein kinase Chk1 / O14757* / checkpoint kinase 1*  / reaction
 ENSMUSG00000029521 Chek2 / Q9Z265 / Serine/threonine-protein kinase Chk2 / O96017* / checkpoint kinase 2*  / reaction
 ENSMUSG00000041431 Ccnb1 / P24860 / G2/mitotic-specific cyclin-B1 / P14635* / cyclin B1*  / reaction
 ENSMUSG00000019942 Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*  / reaction
 ENSMUSG00000028680 Plk3 / serine/threonine-protein kinase PLK3 isoform 2 / Q9H4B4* / polo like kinase 3*  / reaction






 

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