ENSMUSG00000027330


Mus musculus

Features
Gene ID: ENSMUSG00000027330
  
Biological name :Cdc25b
  
Synonyms : Cdc25b / M-phase inducer phosphatase 2 / P30306
  
Possible biological names infered from orthology : cell division cycle 25B / P30305
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F1
Gene start: 131186949
Gene end: 131198497
  
Corresponding Affymetrix probe sets: 10476252 (MoGene1.0st)   1421963_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028804
Ensembl peptide - ENSMUSP00000078784
NCBI entrez gene - 12531     See in Manteia.
MGI - MGI:99701
RefSeq - NM_023117
RefSeq - NM_001111075
RefSeq Peptide - NP_001104545
RefSeq Peptide - NP_075606
swissprot - P30306
swissprot - Q3U535
swissprot - Q9DBN8
Ensembl - ENSMUSG00000027330
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc25bENSDARG00000010792Danio rerio
 CDC25BENSG00000101224Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdc25a / P48964 / M-phase inducer phosphatase 1 / P30304* / cell division cycle 25A*ENSMUSG0000003247740
Cdc25c / P48967 / cell division cycle 25C / P30307*ENSMUSG0000004420126


Protein motifs (from Interpro)
Interpro ID Name
 IPR000751  M-phase inducer phosphatase
 IPR001763  Rhodanese-like domain
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001556 oocyte maturation IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007144 female meiosis I IMP
 biological_processGO:0032467 positive regulation of cytokinesis IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IMP
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:1902751 positive regulation of cell cycle G2/M phase transition IEA
 cellular_componentGO:0000922 spindle pole ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000489 abnormal large intestine morphology "structural or developmental anomalies of the intestinum crassum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pink1tm1Hbu/Pink1tm1Hbu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Pink1tm1Hbu/Pink1tm1Hbu
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdc25atm1.1Hpw/Cdc25atm1.1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0008142 decreased small intestinal villus size "reduced size of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008885 increased enterocyte apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0010157 abnormal small intestinal crypt cell proliferation "anomaly in the ability of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine to undergo expansion by cell division" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0010159 abnormal enterocyte differentiation "abnormal formation of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0013958 decreased small intestine length "reduced length of the portion of the digestive tube between the stomach and the cecum, consisting of the duodenum, ileum and jejunum" [ISBN:0683400088]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0014082 decreased small intestinal villus height "decreased height of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; usually accompanied by crypt elongation or hyperplasia" [MGI:Anna, PMID:16679353]
Show

Allelic Composition: Cdc25atm1Hpw/Cdc25atm1.1Hpw,Cdc25btm1Pjd/Cdc25btm1Pjd,Cdc25ctm1Hpw/Cdc25ctm1Hpw,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019942 Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*  / reaction
 ENSMUSG00000032218 Ccnb2 / P30276 / G2/mitotic-specific cyclin-B2 / O95067* / cyclin B2*  / reaction
 ENSMUSG00000041431 Ccnb1 / P24860 / G2/mitotic-specific cyclin-B1 / P14635* / cyclin B1*  / reaction






 

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