ENSG00000101224


Homo sapiens

Features
Gene ID: ENSG00000101224
  
Biological name :CDC25B
  
Synonyms : CDC25B / cell division cycle 25B / P30305
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: p13
Gene start: 3786772
Gene end: 3806121
  
Corresponding Affymetrix probe sets: 201853_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000245960
Ensembl peptide - ENSP00000339170
Ensembl peptide - ENSP00000368918
Ensembl peptide - ENSP00000405972
Ensembl peptide - ENSP00000339125
NCBI entrez gene - 994     See in Manteia.
OMIM - 116949
RefSeq - NM_001287524
RefSeq - NM_001287516
RefSeq - NM_001287517
RefSeq - NM_001287518
RefSeq - NM_001287519
RefSeq - NM_001287520
RefSeq - NM_001287522
RefSeq - NM_004358
RefSeq - NM_021872
RefSeq - NM_021873
RefSeq Peptide - NP_068658
RefSeq Peptide - NP_001274453
RefSeq Peptide - NP_004349
RefSeq Peptide - NP_068659
RefSeq Peptide - NP_001274445
RefSeq Peptide - NP_001274446
RefSeq Peptide - NP_001274447
RefSeq Peptide - NP_001274448
RefSeq Peptide - NP_001274449
RefSeq Peptide - NP_001274451
swissprot - P30305
swissprot - G8JLH2
swissprot - B4DIG0
Ensembl - ENSG00000101224
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc25bENSDARG00000010792Danio rerio
 Cdc25bENSMUSG00000027330Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDC25A / P30304 / cell division cycle 25AENSG0000016404542
CDC25C / P30307 / cell division cycle 25CENSG0000015840229


Protein motifs (from Interpro)
Interpro ID Name
 IPR000751  M-phase inducer phosphatase
 IPR001763  Rhodanese-like domain
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0000278 mitotic cell cycle TAS
 biological_processGO:0001556 oocyte maturation IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007144 female meiosis I IEA
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0032467 positive regulation of cytokinesis IMP
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:1902751 positive regulation of cell cycle G2/M phase transition IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity TAS
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimers disease models


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000170312 CDK1 / P06493 / cyclin dependent kinase 1  / reaction
 ENSG00000157456 CCNB2 / O95067 / cyclin B2  / reaction
 ENSG00000134057 CCNB1 / P14635 / cyclin B1  / reaction
 ENSG00000164885 CDK5 / Q00535 / cyclin dependent kinase 5  / reaction






 

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