ENSG00000164045


Homo sapiens

Features
Gene ID: ENSG00000164045
  
Biological name :CDC25A
  
Synonyms : CDC25A / cell division cycle 25A / P30304
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.31
Gene start: 48157146
Gene end: 48188402
  
Corresponding Affymetrix probe sets: 1555772_a_at (Human Genome U133 Plus 2.0 Array)   204695_at (Human Genome U133 Plus 2.0 Array)   204696_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000303706
Ensembl peptide - ENSP00000416483
Ensembl peptide - ENSP00000404285
Ensembl peptide - ENSP00000343166
NCBI entrez gene - 993     See in Manteia.
OMIM - 116947
RefSeq - NM_201567
RefSeq - XM_011534316
RefSeq - XM_006713435
RefSeq - XM_006713434
RefSeq - NM_001789
RefSeq Peptide - NP_001780
RefSeq Peptide - NP_963861
swissprot - C9JFR5
swissprot - P30304
swissprot - A0A024R2R6
swissprot - A0A024R2S4
swissprot - C9JH94
Ensembl - ENSG00000164045
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdc25bENSDARG00000010792Danio rerio
 CDC25AENSGALG00000038469Gallus gallus
 Cdc25aENSMUSG00000032477Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDC25B / P30305 / cell division cycle 25BENSG0000010122446
CDC25C / P30307 / cell division cycle 25CENSG0000015840231


Protein motifs (from Interpro)
Interpro ID Name
 IPR000751  M-phase inducer phosphatase
 IPR001763  Rhodanese-like domain
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0009314 response to radiation IDA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0034644 cellular response to UV IDA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051726 regulation of cell cycle TAS
 biological_processGO:1902751 positive regulation of cell cycle G2/M phase transition IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004721 phosphoprotein phosphatase activity TAS
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0051087 chaperone binding IPI


Pathways (from Reactome)
Pathway description
Transcription of E2F targets under negative control by DREAM complex
Polo-like kinase mediated events
Activation of ATR in response to replication stress
Ub-specific processing proteases
Cyclin E associated events during G1/S transition
Cyclin A/B1/B2 associated events during G2/M transition
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Cyclin A:Cdk2-associated events at S phase entry
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimers disease models


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164885 CDK5 / Q00535 / cyclin dependent kinase 5  / reaction
 ENSG00000105173 CCNE1 / P24864 / cyclin E1  / reaction
 ENSG00000134057 CCNB1 / P14635 / cyclin B1  / reaction
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / reaction
 ENSG00000175305 CCNE2 / O96020 / cyclin E2  / reaction
 ENSG00000170312 CDK1 / P06493 / cyclin dependent kinase 1  / reaction
 ENSG00000149554 CHEK1 / O14757 / checkpoint kinase 1  / reaction
 ENSG00000223443 Q6R6M4 / USP17L2 / ubiquitin specific peptidase 17-like family member 2  / complex
 ENSG00000183765 CHEK2 / O96017 / checkpoint kinase 2  / reaction






 

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