ENSG00000175305


Homo sapiens

Features
Gene ID: ENSG00000175305
  
Biological name :CCNE2
  
Synonyms : CCNE2 / cyclin E2 / O96020
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q22.1
Gene start: 94879770
Gene end: 94896678
  
Corresponding Affymetrix probe sets: 205034_at (Human Genome U133 Plus 2.0 Array)   211814_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000430060
Ensembl peptide - ENSP00000379437
Ensembl peptide - ENSP00000430875
Ensembl peptide - ENSP00000428988
Ensembl peptide - ENSP00000429089
Ensembl peptide - ENSP00000309181
NCBI entrez gene - 9134     See in Manteia.
OMIM - 603775
RefSeq - NM_057749
RefSeq - XM_011517366
RefSeq - XM_017013957
RefSeq - XM_017013958
RefSeq - XM_017013959
RefSeq Peptide - NP_477097
swissprot - O96020
swissprot - E5RHN2
swissprot - A0A024R9B0
swissprot - H0YBQ2
swissprot - E5RK20
swissprot - Q8WUE3
Ensembl - ENSG00000175305
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccne2ENSDARG00000098529Danio rerio
 CCNE2ENSGALG00000040794Gallus gallus
 Ccne2ENSMUSG00000028212Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCNE1 / P24864 / cyclin E1ENSG0000010517349
CCNB1 / P14635 / cyclin B1ENSG0000013405721
CCNA2 / P20248 / cyclin A2ENSG0000014538620
CCNA1 / P78396 / cyclin A1ENSG0000013310119
CCNB3 / Q8WWL7 / cyclin B3ENSG0000014708219
CCNB2 / O95067 / cyclin B2ENSG0000015745619
CCND3 / P30281 / cyclin D3ENSG0000011257617
CCND1 / P24385 / cyclin D1ENSG0000011009216
CCND2 / P30279 / cyclin D2ENSG0000011897116
CCNO / P22674 / cyclin OENSG0000015266914


Protein motifs (from Interpro)
Interpro ID Name
 IPR004367  Cyclin, C-terminal domain
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR028858  Cyclin E
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0006270 DNA replication initiation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007129 synapsis IEA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0070192 chromosome organization involved in meiotic cell cycle IEA
 biological_processGO:1903827 regulation of cellular protein localization IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0097135 cyclin E2-CDK2 complex IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
G0 and Early G1
SCF(Skp2)-mediated degradation of p27/p21
DNA Damage/Telomere Stress Induced Senescence
Association of TriC/CCT with target proteins during biosynthesis
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
CDK-mediated phosphorylation and removal of Cdc6
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
p53-Dependent G1 DNA Damage Response


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000111276 CDKN1B / P46527 / cyclin dependent kinase inhibitor 1B  / complex
 ENSG00000124762 CDKN1A / P38936 / cyclin dependent kinase inhibitor 1A  / complex
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / complex / reaction
 ENSG00000139687 RB1 / P06400 / RB transcriptional corepressor 1  / reaction / complex
 ENSG00000173207 CKS1B / P61024 / CDC28 protein kinase regulatory subunit 1B  / reaction / complex
 ENSG00000145604 SKP2 / Q13309 / S-phase kinase associated protein 2  / complex / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / reaction / complex
 ENSG00000094804 CDC6 / Q99741 / cell division cycle 6  / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / reaction / complex
 ENSG00000164045 CDC25A / P30304 / cell division cycle 25A  / reaction






 

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