ENSG00000113558


Homo sapiens

Features
Gene ID: ENSG00000113558
  
Biological name :SKP1
  
Synonyms : P63208 / SKP1 / S-phase kinase associated protein 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q31.1
Gene start: 134148935
Gene end: 134177038
  
Corresponding Affymetrix probe sets: 200711_s_at (Human Genome U133 Plus 2.0 Array)   200718_s_at (Human Genome U133 Plus 2.0 Array)   200719_at (Human Genome U133 Plus 2.0 Array)   207974_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429415
Ensembl peptide - ENSP00000429472
Ensembl peptide - ENSP00000431067
Ensembl peptide - ENSP00000430885
Ensembl peptide - ENSP00000429996
Ensembl peptide - ENSP00000429995
Ensembl peptide - ENSP00000429961
Ensembl peptide - ENSP00000429686
Ensembl peptide - ENSP00000231487
Ensembl peptide - ENSP00000331708
Ensembl peptide - ENSP00000428962
NCBI entrez gene - 6500     See in Manteia.
OMIM - 601434
RefSeq - NM_170679
RefSeq - NM_006930
RefSeq Peptide - NP_008861
RefSeq Peptide - NP_733779
swissprot - E5RGM4
swissprot - E5RGM3
swissprot - F8W8N3
swissprot - E7ERH2
swissprot - P63208
swissprot - E5RK33
swissprot - E5RJR5
swissprot - E5RHM3
Ensembl - ENSG00000113558
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 skp1ENSDARG00000003151Danio rerio
 SKP1ENSGALG00000006474Gallus gallus
 Skp1aENSMUSG00000036309Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AC104109.3ENSG0000027277234


Protein motifs (from Interpro)
Interpro ID Name
 IPR001232  S-phase kinase-associated protein 1-like
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR016072  SKP1 component, dimerisation
 IPR016073  SKP1 component, POZ domain
 IPR016897  S-phase kinase-associated protein 1
 IPR036296  SKP1-like, dimerisation domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006879 cellular iron ion homeostasis TAS
 biological_processGO:0010265 SCF complex assembly TAS
 biological_processGO:0010972 negative regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0016055 Wnt signaling pathway TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0035518 histone H2A monoubiquitination IDA
 biological_processGO:0038061 NIK/NF-kappaB signaling TAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0051403 stress-activated MAPK cascade TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0051457 maintenance of protein location in nucleus IPI
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IDA
 cellular_componentGO:0031467 Cul7-RING ubiquitin ligase complex IDA
 cellular_componentGO:0031519 PcG protein complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IDA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA
 molecular_functionGO:0097602 cullin family protein binding IPI


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
Vpu mediated degradation of CD4
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Circadian Clock
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010610 CD4 / P01730 / CD4 molecule  / complex / reaction
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / reaction / complex
 ENSG00000077150 NFKB2 / Q00653 / nuclear factor kappa B subunit 2  / complex / reaction
 ENSG00000111276 CDKN1B / P46527 / cyclin dependent kinase inhibitor 1B  / complex / reaction
 ENSG00000109320 NFKB1 / P19838 / nuclear factor kappa B subunit 1  / reaction / complex
 ENSG00000104856 RELB / Q01201 / RELB proto-oncogene, NF-kB subunit  / complex / reaction
 ENSG00000129559 NEDD8 / Q15843 / neural precursor cell expressed, developmentally down-regulated 8  / complex / reaction
 ENSG00000124762 CDKN1A / P38936 / cyclin dependent kinase inhibitor 1A  / reaction / complex
 ENSG00000082701 GSK3B / P49841 / glycogen synthase kinase 3 beta  / complex / reaction
 ENSG00000105173 CCNE1 / P24864 / cyclin E1  / complex / reaction
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / reaction / complex
 ENSG00000103479 RBL2 / Q08999 / RB transcriptional corepressor like 2  / complex / reaction
 ENSG00000107968 MAP3K8 / P41279 / mitogen-activated protein kinase kinase kinase 8  / complex / reaction
 ENSG00000072803 FBXW11 / Q9UKB1 / F-box and WD repeat domain containing 11  / complex
 ENSG00000043093 Q96GG9 / DCUN1D1 / defective in cullin neddylation 1 domain containing 1  / complex / reaction
 ENSG00000087586 AURKA / O14965 / aurora kinase A  / reaction / complex
 ENSG00000175305 CCNE2 / O96020 / cyclin E2  / complex / reaction
 ENSG00000173163 COMMD1 / Q8N668 / copper metabolism domain containing 1  / complex / reaction
 ENSG00000168884 TNIP2 / Q8NFZ5 / TNFAIP3 interacting protein 2  / complex / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / reaction / complex
 ENSG00000183580 FBXL7 / Q9UJT9 / F-box and leucine rich repeat protein 7  / complex / reaction
 ENSG00000118564 FBXL5 / Q9UKA1 / F-box and leucine rich repeat protein 5  / complex / reaction
 ENSG00000100906 NFKBIA / P25963 / NFKB inhibitor alpha  / reaction / complex
 ENSG00000172179 PRL / P01236 / prolactin  / complex / reaction
 ENSG00000162924 REL / Q04864 / REL proto-oncogene, NF-kB subunit  / complex / reaction
 ENSG00000148400 NOTCH1 / P46531  / reaction / complex
 ENSG00000113494 PRLR / P16471 / prolactin receptor  / reaction / complex
 ENSG00000188215 Q8IWE4 / DCUN1D3 / defective in cullin neddylation 1 domain containing 3  / complex / reaction
 ENSG00000146232 NFKBIE / O00221 / NFKB inhibitor epsilon  / complex / reaction
 ENSG00000105325 FZR1 / Q9UM11 / fizzy and cell division cycle 20 related 1  / complex / reaction
 ENSG00000136122 BORA / Q6PGQ7 / bora, aurora kinase A activator  / reaction / complex
 ENSG00000136487 GH2 / P01242 / growth hormone 2  / complex / reaction
 ENSG00000112029 FBXO5 / Q9UKT4 / F-box protein 5  / complex / reaction
 ENSG00000136488 CSH1 / P0DML2 / chorionic somatomammotropin hormone 1  / complex / reaction
 ENSG00000104825 NFKBIB / Q15653 / NFKB inhibitor beta  / reaction / complex
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction / complex
 ENSG00000145604 SKP2 / Q13309 / S-phase kinase associated protein 2  / complex
 ENSG00000117399 CDC20 / Q12834 / cell division cycle 20  / reaction / complex
 ENSG00000173207 CKS1B / P61024 / CDC28 protein kinase regulatory subunit 1B  / reaction / complex
 ENSG00000173039 RELA / Q04206 / RELA proto-oncogene, NF-kB subunit  / complex / reaction
 ENSG00000130725 UBE2M / P61081 / ubiquitin conjugating enzyme E2 M  / complex / reaction
 ENSG00000259384 GH1 / P01241 / growth hormone 1  / reaction / complex
 ENSG00000101997 CCDC22 / O60826 / coiled-coil domain containing 22  / reaction / complex
 ENSG00000109670 FBXW7 / Q969H0 / F-box and WD repeat domain containing 7  / complex
 ENSG00000124813 RUNX2 / Q13950 / runt related transcription factor 2  / complex / reaction
 ENSG00000006062 Q99558 / MAP3K14 / mitogen-activated protein kinase kinase kinase 14  / reaction / complex
 ENSG00000166167 BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase  / reaction / complex
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / reaction / complex
 ENSG00000155034 FBXL18 / Q96ME1 / F-box and leucine rich repeat protein 18  / complex
 ENSG00000111530 CAND1 / Q86VP6 / cullin associated and neddylation dissociated 1  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr