ENSG00000111530


Homo sapiens

Features
Gene ID: ENSG00000111530
  
Biological name :CAND1
  
Synonyms : CAND1 / cullin associated and neddylation dissociated 1 / Q86VP6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q14.3
Gene start: 67269281
Gene end: 67319951
  
Corresponding Affymetrix probe sets: 1556318_s_at (Human Genome U133 Plus 2.0 Array)   207483_s_at (Human Genome U133 Plus 2.0 Array)   208838_at (Human Genome U133 Plus 2.0 Array)   208839_s_at (Human Genome U133 Plus 2.0 Array)   235224_s_at (Human Genome U133 Plus 2.0 Array)   239771_at (Human Genome U133 Plus 2.0 Array)   243910_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000442318
Ensembl peptide - ENSP00000445794
Ensembl peptide - ENSP00000444089
Ensembl peptide - ENSP00000437594
NCBI entrez gene - 55832     See in Manteia.
OMIM - 607727
RefSeq - NM_018448
RefSeq Peptide - NP_060918
swissprot - Q86VP6
swissprot - H0YH27
swissprot - F5H6I6
swissprot - A0A0C4DGH5
Ensembl - ENSG00000111530
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cand1ENSDARG00000017841Danio rerio
 ENSGALG00000009899Gallus gallus
 ENSGALG00000033879Gallus gallus
 Cand1ENSMUSG00000020114Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CAND2 / O75155 / cullin associated and neddylation dissociated 2 (putative)ENSG0000014471262


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR013932  TATA-binding protein interacting (TIP20)
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006879 cellular iron ion homeostasis TAS
 biological_processGO:0010265 SCF complex assembly IDA
 biological_processGO:0016567 protein ubiquitination IDA
 biological_processGO:0030154 cell differentiation IDA
 biological_processGO:0043086 negative regulation of catalytic activity IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex IDA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017025 TBP-class protein binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Neddylation
Iron uptake and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / reaction / complex
 ENSG00000167986 DDB1 / Q16531 / damage specific DNA binding protein 1  / complex / reaction
 ENSG00000173163 COMMD1 / Q8N668 / copper metabolism domain containing 1  / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex / reaction
 ENSG00000158290 CUL4B / Q13620 / cullin 4B  / complex / reaction
 ENSG00000139842 CUL4A / Q13619 / cullin 4A  / reaction / complex
 ENSG00000101997 CCDC22 / O60826 / coiled-coil domain containing 22  / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / reaction / complex
 ENSG00000036257 CUL3 / Q13618 / cullin 3  / reaction / complex






 

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