ENSG00000167986


Homo sapiens

Features
Gene ID: ENSG00000167986
  
Biological name :DDB1
  
Synonyms : damage specific DNA binding protein 1 / DDB1 / Q16531
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q12.2
Gene start: 61299451
Gene end: 61342596
  
Corresponding Affymetrix probe sets: 208619_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000440269
Ensembl peptide - ENSP00000440660
Ensembl peptide - ENSP00000441825
Ensembl peptide - ENSP00000444105
Ensembl peptide - ENSP00000445554
Ensembl peptide - ENSP00000445844
Ensembl peptide - ENSP00000301764
NCBI entrez gene - 1642     See in Manteia.
OMIM - 600045
RefSeq - NM_001923
RefSeq Peptide - NP_001914
swissprot - Q16531
swissprot - F5GWI0
swissprot - F5GY55
swissprot - F5GYG8
swissprot - F5GZY8
swissprot - F5H198
swissprot - F5H2L3
Ensembl - ENSG00000167986
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddb1ENSDARG00000074431Danio rerio
 DDB1ENSGALG00000042333Gallus gallus
 Ddb1ENSMUSG00000024740Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SF3B3 / Q15393 / splicing factor 3b subunit 3ENSG0000018909123


Protein motifs (from Interpro)
Interpro ID Name
 IPR004871  Cleavage/polyadenylation specificity factor, A subunit, C-terminal
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR031297  DNA damage-binding protein 1
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000715 nucleotide-excision repair, DNA damage recognition TAS
 biological_processGO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0006289 nucleotide-excision repair TAS
 biological_processGO:0006293 nucleotide-excision repair, preincision complex stabilization TAS
 biological_processGO:0006294 nucleotide-excision repair, preincision complex assembly TAS
 biological_processGO:0006295 nucleotide-excision repair, DNA incision, 3"-to lesion TAS
 biological_processGO:0006296 nucleotide-excision repair, DNA incision, 5"-to lesion TAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0010498 proteasomal protein catabolic process IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016567 protein ubiquitination IMP
 biological_processGO:0033683 nucleotide-excision repair, DNA incision TAS
 biological_processGO:0035518 histone H2A monoubiquitination IDA
 biological_processGO:0042769 DNA damage response, detection of DNA damage TAS
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045070 positive regulation of viral genome replication IMP
 biological_processGO:0045732 positive regulation of protein catabolic process IMP
 biological_processGO:0046726 positive regulation by virus of viral protein levels in host cell IMP
 biological_processGO:0051702 interaction with symbiont IDA
 biological_processGO:0070911 global genome nucleotide-excision repair TAS
 biological_processGO:0070914 UV-damage excision repair IDA
 biological_processGO:1901990 regulation of mitotic cell cycle phase transition IMP
 biological_processGO:1902188 positive regulation of viral release from host cell IMP
 cellular_componentGO:0000784 nuclear chromosome, telomeric region HDA
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031464 Cul4A-RING E3 ubiquitin ligase complex IDA
 cellular_componentGO:0031465 Cul4B-RING E3 ubiquitin ligase complex IDA
 cellular_componentGO:0032991 protein-containing complex IMP
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0080008 Cul4-RING E3 ubiquitin ligase complex IMP
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003684 damaged DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030674 protein binding, bridging IPI
 molecular_functionGO:0044877 protein-containing complex binding IPI
 molecular_functionGO:0071987 WD40-repeat domain binding IPI
 molecular_functionGO:0097602 cullin family protein binding IPI


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / complex / reaction
 ENSG00000106628 POLD2 / P49005 / DNA polymerase delta 2, accessory subunit  / complex / reaction
 ENSG00000130725 UBE2M / P61081 / ubiquitin conjugating enzyme E2 M  / complex / reaction
 ENSG00000129559 NEDD8 / Q15843 / neural precursor cell expressed, developmentally down-regulated 8  / reaction / complex
 ENSG00000077514 POLD3 / Q15054 / DNA polymerase delta 3, accessory subunit  / reaction / complex
 ENSG00000134574 DDB2 / Q92466 / damage specific DNA binding protein 2  / complex
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / reaction / complex
 ENSG00000175482 POLD4 / Q9HCU8 / DNA polymerase delta 4, accessory subunit  / reaction / complex
 ENSG00000154767 XPC / Q01831 / XPC complex subunit, DNA damage recognition and repair factor  / complex / reaction
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / complex / reaction
 ENSG00000111530 CAND1 / Q86VP6 / cullin associated and neddylation dissociated 1  / complex / reaction
 ENSG00000143476 DTL / Q9NZJ0 / denticleless E3 ubiquitin protein ligase homolog  / complex
 ENSG00000225830 ERCC6 / P0DP91 / Q03468 / Q8N328 / ERCC excision repair 6, chromatin remodeling factor  / complex / reaction
 ENSG00000139842 CUL4A / Q13619 / cullin 4A  / complex
 ENSG00000131778 CHD1L / Q86WJ1 / chromodomain helicase DNA binding protein 1 like  / reaction / complex
 ENSG00000158290 CUL4B / Q13620 / cullin 4B  / complex
 ENSG00000049167 ERCC8 / Q13216 / ERCC excision repair 8, CSA ubiquitin ligase complex subunit  / complex
 ENSG00000147400 CETN2 / P41208 / centrin 2  / complex / reaction
 ENSG00000119318 P54727 / RAD23B / RAD23 homolog B, nucleotide excision repair protein  / complex / reaction
 ENSG00000173163 COMMD1 / Q8N668 / copper metabolism domain containing 1  / complex / reaction
 ENSG00000121022 COPS5 / Q92905 / COP9 signalosome subunit 5  / reaction
 ENSG00000143799 PARP1 / P09874 / poly(ADP-ribose) polymerase 1  / complex / reaction
 ENSG00000136936 XPA / P23025 / XPA, DNA damage recognition and repair factor  / complex / reaction
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / complex / reaction
 ENSG00000101997 CCDC22 / O60826 / coiled-coil domain containing 22  / complex / reaction
 ENSG00000062822 POLD1 / P28340 / DNA polymerase delta 1, catalytic subunit  / reaction / complex






 

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