ENSG00000121022


Homo sapiens

Features
Gene ID: ENSG00000121022
  
Biological name :COPS5
  
Synonyms : COP9 signalosome subunit 5 / COPS5 / Q92905
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q13.1
Gene start: 67043079
Gene end: 67083783
  
Corresponding Affymetrix probe sets: 201652_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000350512
Ensembl peptide - ENSP00000429774
Ensembl peptide - ENSP00000428586
Ensembl peptide - ENSP00000428124
Ensembl peptide - ENSP00000427997
Ensembl peptide - ENSP00000427869
NCBI entrez gene - 10987     See in Manteia.
OMIM - 604850
RefSeq - NM_006837
RefSeq Peptide - NP_006828
swissprot - E5RG35
swissprot - E5RFS1
swissprot - A0A024R7W9
swissprot - E5RK55
swissprot - Q92905
swissprot - E5RHH5
swissprot - E5RHF2
Ensembl - ENSG00000121022
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cops5ENSDARG00000057624Danio rerio
 COPS5ENSGALG00000030843Gallus gallus
 Cops5ENSMUSG00000025917Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000555  JAB1/MPN/MOV34 metalloenzyme domain
 IPR037518  MPN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000338 protein deneddylation IMP
 biological_processGO:0000715 nucleotide-excision repair, DNA damage recognition TAS
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006412 translation TAS
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0016579 protein deubiquitination IDA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046328 regulation of JNK cascade IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:1903894 regulation of IRE1-mediated unfolded protein response IMP
 biological_processGO:1990182 exosomal secretion IDA
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005852 eukaryotic translation initiation factor 3 complex TAS
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0008180 COP9 signalosome IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0003743 translation initiation factor activity TAS
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IMP
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019784 NEDD8-specific protease activity TAS
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0035718 macrophage migration inhibitory factor binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / reaction
 ENSG00000129559 NEDD8 / Q15843 / neural precursor cell expressed, developmentally down-regulated 8  / reaction
 ENSG00000173163 COMMD1 / Q8N668 / copper metabolism domain containing 1  / reaction
 ENSG00000101997 CCDC22 / O60826 / coiled-coil domain containing 22  / reaction
 ENSG00000158290 CUL4B / Q13620 / cullin 4B  / reaction
 ENSG00000139842 CUL4A / Q13619 / cullin 4A  / reaction
 ENSG00000167986 DDB1 / Q16531 / damage specific DNA binding protein 1  / reaction






 

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