ENSMUSG00000025917


Mus musculus

Features
Gene ID: ENSMUSG00000025917
  
Biological name :Cops5
  
Synonyms : COP9 signalosome complex subunit 5 / Cops5 / O35864
  
Possible biological names infered from orthology : COP9 signalosome subunit 5 / Q92905
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: A2
Gene start: 10024601
Gene end: 10038168
  
Corresponding Affymetrix probe sets: 10353050 (MoGene1.0st)   1439243_x_at (Mouse Genome 430 2.0 Array)   1460171_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027050
Ensembl peptide - ENSMUSP00000140633
Ensembl peptide - ENSMUSP00000140115
Ensembl peptide - ENSMUSP00000140054
NCBI entrez gene - 26754     See in Manteia.
MGI - MGI:1349415
RefSeq - NM_013715
RefSeq - NM_001277101
RefSeq Peptide - NP_001264030
RefSeq Peptide - NP_038743
swissprot - O35864
swissprot - A0A087WQA8
swissprot - A0A087WQ60
swissprot - A0A087WRH6
Ensembl - ENSMUSG00000025917
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cops5ENSDARG00000057624Danio rerio
 COPS5ENSGALG00000030843Gallus gallus
 COPS5ENSG00000121022Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000555  JAB1/MPN/MOV34 metalloenzyme domain
 IPR037518  MPN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000338 protein deneddylation IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046328 regulation of JNK cascade IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:1903894 regulation of IRE1-mediated unfolded protein response IEA
 biological_processGO:1990182 exosomal secretion IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0008180 COP9 signalosome IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0035718 macrophage migration inhibitory factor binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cops5tm1Fxc/Cops5tm1Fxc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Cops5tm1Rpar/Cops5tm1Rpar,Tg(Lck-cre)548Jxm/0,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

Allelic Composition: Cops5tm1Rpar/Cops5tm1Rpar,Tg(Lck-cre)548Jxm/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Asgr2tm1Her/Asgr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Asgr2tm1Her/Asgr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
Show

Allelic Composition: Asgr2tm1Her/Asgr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Asgr2tm1Her/Asgr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cops5tm1Fxc/Cops5tm1Fxc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Asgr2tm1Her/Asgr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-4Btlr/Oca2p-4Btlr
Genetic Background: C57BL/6J-Oca2p-4Btlr

 MP:0003085 abnormal egg cylinder morphology "anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cops5tm1Fxc/Cops5tm1Fxc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cops5tm1Fxc/Cops5tm1Fxc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004029 spontaneous chromosome breakage "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Cops5tm1Fxc/Cops5tm1Fxc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004965 inner cell mass degeneration 
Show

Allelic Composition: Asgr2tm1Her/Asgr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Cops5tm1Fxc/Cops5tm1Fxc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010039 abnormal trophoblast giant cell proliferation "abnormality in the expansion rate of the trophoblast giant cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Asgr2tm1Her/Asgr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010380 inner cell mass apoptosis "the cells of the blastocyst that develop into the body of the embryo are undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cops5tm1Fxc/Cops5tm1Fxc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Asgr2tm1Her/Asgr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cops5tm1Fxc/Cops5tm1Fxc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0012113 decreased inner cell mass proliferation 
Show

Allelic Composition: Cops5tm1Fxc/Cops5tm1Fxc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Asgr2tm1Her/Asgr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Cops5tm1Fxc/Cops5tm1Fxc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0013589 thymus medulla hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, of the inner area of thymus lobules" [MGI:Anna]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031095 Cul4b / A2A432 / Cullin-4B / Q13620*  / reaction
 ENSMUSG00000024740 Ddb1 / Q3U1J4 / DNA damage-binding protein 1 / Q16531* / damage specific DNA binding protein 1*  / reaction
 ENSMUSG00000031446 Cul4a / Q3TCH7 / Cullin-4A / Q13619*  / reaction
 ENSMUSG00000010376 Nedd8 / P29595 / Q15843* / neural precursor cell expressed, developmentally down-regulated 8*  / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / reaction
 ENSMUSG00000051355 Commd1 / Q8K4M5 / COMM domain-containing protein 1 / Q8N668* / copper metabolism domain containing 1*  / reaction
 ENSMUSG00000031143 Ccdc22 / Q9JIG7 / Coiled-coil domain-containing protein 22 / O60826* / coiled-coil domain containing 22*  / reaction






 

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