ENSMUSG00000031095


Mus musculus

Features
Gene ID: ENSMUSG00000031095
  
Biological name :Cul4b
  
Synonyms : A2A432 / Cul4b / Cullin-4B
  
Possible biological names infered from orthology : Q13620
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A3.3
Gene start: 38533274
Gene end: 38576196
  
Corresponding Affymetrix probe sets: 10604199 (MoGene1.0st)   1417453_at (Mouse Genome 430 2.0 Array)   1417454_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059276
Ensembl peptide - ENSMUSP00000136083
Ensembl peptide - ENSMUSP00000110771
Ensembl peptide - ENSMUSP00000016681
NCBI entrez gene - 72584     See in Manteia.
MGI - MGI:1919834
RefSeq - NM_028288
RefSeq - NM_001110142
RefSeq Peptide - NP_082564
RefSeq Peptide - NP_001103612
swissprot - A2A432
swissprot - E9PXY1
swissprot - J3QJX0
Ensembl - ENSMUSG00000031095
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cul4bENSDARG00000060510Danio rerio
 CUL4BENSGALG00000008559Gallus gallus
 CUL4BENSG00000158290Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cul4a / Q3TCH7 / Cullin-4A / Q13619*ENSMUSG0000003144664
Cul3 / Q9JLV5 / Cullin-3 / Q13618*ENSMUSG0000000436430
Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*ENSMUSG0000002968624
Cul5 / cullin 5 / Q93034*ENSMUSG0000003203022
Cul2 / Q9D4H8 / Cullin-2 / Q13617*ENSMUSG0000002423122


Protein motifs (from Interpro)
Interpro ID Name
 IPR001373  Cullin, N-terminal
 IPR016157  Cullin, conserved site
 IPR016158  Cullin homology domain
 IPR016159  Cullin repeat-like-containing domain superfamily
 IPR019559  Cullin protein, neddylation domain
 IPR033044  Cullin-4B
 IPR036317  Cullin homology domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010498 proteasomal protein catabolic process ISO
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0035518 histone H2A monoubiquitination ISO
 biological_processGO:0045732 positive regulation of protein catabolic process IMP
 biological_processGO:0070914 UV-damage excision repair ISO
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex IEA
 cellular_componentGO:0031465 Cul4B-RING E3 ubiquitin ligase complex IBA
 cellular_componentGO:0080008 Cul4-RING E3 ubiquitin ligase complex ISO
 molecular_functionGO:0003684 damaged DNA binding ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding IBA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cul4btm1Yxg/Cul4btm1Yxg
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Cul4btm1.1Pz/Y,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cul4btm1Yxg/Cul4btm1Yxg
Genetic Background: involves: 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Cul4btm1Yxg/Cul4btm1Yxg
Genetic Background: involves: 129X1/SvJ

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cul4btm1.1Pz/Cul4btm1.1Pz
Genetic Background: involves: 129 * C57BL/6J

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cul4btm1.1Pz/Y,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0001693 failure of primitive streak formation "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
Show

Allelic Composition: Cul4btm1.1Pz/Y,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Cul4btm1Yxg/Cul4btm1Yxg
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Cul4btm1.1Yxg/Cul4b+
Genetic Background: involves: 129X1/SvJ * FVB/N

Allelic Composition: Cul4btm1.1Pz/Y,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Cul4btm1Yxg/Cul4btm1Yxg
Genetic Background: involves: 129X1/SvJ

 MP:0001717 absent ectoplacental cone 
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Allelic Composition: Cul4btm1.1Pz/Y,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Cul4btm1Yxg/Cul4btm1Yxg
Genetic Background: involves: 129X1/SvJ

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Cul4btm1.1Pz/Y,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cul4btm1Yxg/Cul4btm1Yxg
Genetic Background: involves: 129X1/SvJ

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sharpincpdm-Dem/Sharpincpdm-Dem
Genetic Background: CBy.OcB3-Sharpincpdm-Dem

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cul4btm1Yxg/Cul4btm1Yxg
Genetic Background: involves: 129X1/SvJ

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cul4btm1Yxg/Cul4btm1Yxg
Genetic Background: involves: 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nxf2tm1.1Jw Nxf3tm1.1Jw/Y,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Cul4btm1Yxg/Cul4btm1Yxg
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Cul4btm1.1Pz/Y
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cul4btm1.1Pz/Cul4btm1.1Pz
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Cul4btm1.1Pz/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0002582 disorganized extraembryonic tissue "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cul4btm1Yxg/Cul4btm1Yxg
Genetic Background: involves: 129X1/SvJ

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Cul4btm1.1Pz/Y,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cul4btm1.1Yxg/Cul4b+
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cul4btm1Yxg/Cul4btm1Yxg
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Cul4btm1.1Yxg/Cul4b+
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cul4btm1.1Yxg/Cul4b+
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cul4btm1.1Yxg/Cul4b+
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cul4btm1.1Yxg/Cul4b+
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0004266 pale placenta "placenta lacking normal reddish coloration, often refers to bloodless condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cul4btm1.1Yxg/Cul4b+
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010382 abnormal dosage compensation, by inactivation of X chromosome "anomaly in the process of compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex" [GO:0009048]
Show

Allelic Composition: Cul4btm1.1Yxg/Cul4b+
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cul4btm1Yxg/Cul4btm1Yxg
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Cul4btm1.1Pz/Y,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cul4btm1.1Pz/Y,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cul4btm1.1Yxg/Cul4b+
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0011112 partial lethality during fetal growth through weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cul4btm1.1Yxg/Cul4b+
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0011527 disorganized placental labyrinth "derangement of the placental layers where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
Show

Allelic Composition: Cul4btm1.1Yxg/Cul4b+
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Cul4btm1Yxg/Cul4btm1Yxg
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Cul4btm1.1Pz/Y,Tg(CAG-cre)13Miya/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000010376 Nedd8 / P29595 / Q15843* / neural precursor cell expressed, developmentally down-regulated 8*  / complex
 ENSMUSG00000054051 Ercc6 / ERCC excision repair 6, chromatin remodeling factor / P0DP91* / Q03468* / Q8N328*  / complex / reaction
 ENSMUSG00000020114 Cand1 / Q6ZQ38 / Cullin-associated NEDD8-dissociated protein 1 / Q86VP6* / cullin associated and neddylation dissociated 1*  / reaction / complex
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction / complex
 ENSMUSG00000020471 Pold2 / O35654 / polymerase (DNA directed), delta 2, regulatory subunit / P49005* / DNA polymerase delta 2, accessory subunit*  / complex / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction / complex
 ENSMUSG00000038644 Pold1 / P52431 / polymerase (DNA directed), delta 1, catalytic subunit / P28340* / DNA polymerase delta 1, catalytic subunit*  / reaction / complex
 ENSMUSG00000028329 Xpa / Q64267 / xeroderma pigmentosum, complementation group A / P23025* / XPA, DNA damage recognition and repair factor*  / reaction / complex
 ENSMUSG00000031347 Cetn2 / Q9R1K9 / Centrin-2 / P41208*  / reaction / complex
 ENSMUSG00000021694 Ercc8 / Q8CFD5 / DNA excision repair protein ERCC-8 / Q13216* / ERCC excision repair 8, CSA ubiquitin ligase complex subunit*  / complex
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / complex / reaction
 ENSMUSG00000030094 Xpc / P51612 / xeroderma pigmentosum, complementation group C / Q01831* / XPC complex subunit, DNA damage recognition and repair factor*  / reaction / complex
 ENSMUSG00000026496 Parp1 / poly (ADP-ribose) polymerase family, member 1 / P09874* / poly(ADP-ribose) polymerase 1*  / reaction / complex
 ENSMUSG00000027342 Pcna / P17918 / proliferating cell nuclear antigen / P12004*  / reaction / complex
 ENSMUSG00000005575 Ube2m / P61082 / ubiquitin-conjugating enzyme E2M / P61081*  / complex
 ENSMUSG00000002109 Ddb2 / Q99J79 / DNA damage-binding protein 2 / Q92466* / damage specific DNA binding protein 2*  / complex
 ENSMUSG00000028426 P54728 / Rad23b / UV excision repair B / P54727* / RAD23 homolog B, nucleotide excision repair protein*  / complex / reaction
 ENSMUSG00000024740 Ddb1 / Q3U1J4 / DNA damage-binding protein 1 / Q16531* / damage specific DNA binding protein 1*  / complex
 ENSMUSG00000024854 Pold4 / Q9CWP8 / polymerase (DNA-directed), delta 4 / Q9HCU8* / AP003419.1* / DNA polymerase delta 4, accessory subunit*  / complex / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex
 ENSMUSG00000025917 Cops5 / O35864 / COP9 signalosome complex subunit 5 / Q92905* / COP9 signalosome subunit 5*  / reaction
 ENSMUSG00000037474 Dtl / Q3TLR7 / Denticleless protein homolog / Q9NZJ0* / denticleless E3 ubiquitin protein ligase homolog*  / complex
 ENSMUSG00000031143 Ccdc22 / Q9JIG7 / Coiled-coil domain-containing protein 22 / O60826* / coiled-coil domain containing 22*  / reaction / complex
 ENSMUSG00000028089 Chd1l / Q9CXF7 / Chromodomain-helicase-DNA-binding protein 1-like / Q86WJ1*  / reaction / complex
 ENSMUSG00000051355 Commd1 / Q8K4M5 / COMM domain-containing protein 1 / Q8N668* / copper metabolism domain containing 1*  / complex / reaction






 

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