ENSMUSG00000026496


Mus musculus

Features
Gene ID: ENSMUSG00000026496
  
Biological name :Parp1
  
Synonyms : Parp1 / poly (ADP-ribose) polymerase family, member 1
  
Possible biological names infered from orthology : P09874 / poly(ADP-ribose) polymerase 1
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H4
Gene start: 180568924
Gene end: 180601254
  
Corresponding Affymetrix probe sets: 10352242 (MoGene1.0st)   1422502_at (Mouse Genome 430 2.0 Array)   1422503_s_at (Mouse Genome 430 2.0 Array)   1435368_a_at (Mouse Genome 430 2.0 Array)   1443573_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027777
Ensembl peptide - ENSMUSP00000142295
Ensembl peptide - ENSMUSP00000141775
Ensembl peptide - ENSMUSP00000141301
NCBI entrez gene - 11545     See in Manteia.
MGI - MGI:1340806
RefSeq - NM_007415
RefSeq Peptide - NP_031441
swissprot - A0A0A6YX03
swissprot - A0A0A6YVX0
swissprot - A0A0A6YY63
swissprot - Q921K2
Ensembl - ENSMUSG00000026496
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 parp1ENSDARG00000019529Danio rerio
 PARP1ENSGALG00000009228Gallus gallus
 PARP1ENSG00000143799Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Parp2 / O88554 / Poly [ADP-ribose] polymerase 2 / Q9UGN5*ENSMUSG0000003602321
Parp3 / poly(ADP-ribose) polymerase family member 3 / Q9Y6F1*ENSMUSG0000002324916


Protein motifs (from Interpro)
Interpro ID Name
 IPR001357  BRCT domain
 IPR001510  Zinc finger, PARP-type
 IPR004102  Poly(ADP-ribose) polymerase, regulatory domain
 IPR008288  Poly [ADP-ribose] polymerase
 IPR008893  WGR domain
 IPR012317  Poly(ADP-ribose) polymerase, catalytic domain
 IPR012982  PADR1 domain
 IPR036420  BRCT domain superfamily
 IPR036616  Poly(ADP-ribose) polymerase, regulatory domain superfamily
 IPR036930  WGR domain superfamily
 IPR036957  Zinc finger, PARP-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006471 protein ADP-ribosylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0010332 response to gamma radiation IEA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0010990 regulation of SMAD protein complex assembly IEA
 biological_processGO:0016540 protein autoprocessing IEA
 biological_processGO:0018312 peptidyl-serine ADP-ribosylation IEA
 biological_processGO:0023019 signal transduction involved in regulation of gene expression IEA
 biological_processGO:0032042 mitochondrial DNA metabolic process IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0033148 positive regulation of intracellular estrogen receptor signaling pathway IEA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0036211 protein modification process IEA
 biological_processGO:0042769 DNA damage response, detection of DNA damage IEA
 biological_processGO:0043504 mitochondrial DNA repair IEA
 biological_processGO:0044030 regulation of DNA methylation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0051901 positive regulation of mitochondrial depolarization IEA
 biological_processGO:0060391 positive regulation of SMAD protein signal transduction IEA
 biological_processGO:0070212 protein poly-ADP-ribosylation IEA
 biological_processGO:0071294 cellular response to zinc ion IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:1900182 positive regulation of protein localization to nucleus IEA
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1903376 regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903518 positive regulation of single strand break repair IEA
 biological_processGO:1903827 regulation of cellular protein localization IEA
 biological_processGO:1904044 response to aldosterone IEA
 biological_processGO:1904646 cellular response to amyloid-beta IEA
 biological_processGO:1904762 positive regulation of myofibroblast differentiation IEA
 biological_processGO:1990966 ATP generation from poly-ADP-D-ribose IEA
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding IEA
 biological_processGO:2001170 negative regulation of ATP biosynthetic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030331 estrogen receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0051287 NAD binding IEA
 molecular_functionGO:0070412 R-SMAD binding IEA
 molecular_functionGO:1990404 protein ADP-ribosylase activity IEA


Pathways (from Reactome)
Pathway description
POLB-Dependent Long Patch Base Excision Repair
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SUMOylation of DNA damage response and repair proteins
HDR through MMEJ (alt-NHEJ)
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp63tm2Brd/Trp63tm2Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd,Parp1tm1Zqw/Parp1tm1Zqw
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tyrc-a/Tyrc-h
Genetic Background: involves: C3H/HeJ

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd,Parp1tm1Zqw/Parp1tm1Zqw
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0001214 skin hyperplasia "increased cell number in the skin; usually results in thick skin" [J:47225]
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Allelic Composition: Trp63tm2Brd/Trp63tm2Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd,Parp1tm1Zqw/Parp1tm1Zqw
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm,Parp2tm1Jmdm/Parp2tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

Allelic Composition: Parp1tm1Zqw/Parp1tm1Zqw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Parp1tm1Zqw/Parp1tm1Zqw
Genetic Background: 129S-Parp1tm1Zqw/J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0002724 enhanced wound healing "increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]
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Allelic Composition: Parp1tm1Zqw/Parp1tm1Zqw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003155 abnormal telomere length "abnormal length of the terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability; normal length is a few hundred base pairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd,Parp1tm1Zqw/Parp1tm1Zqw
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Trp63tm2Brd/Trp63tm2Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Parp1tm1Zqw/Parp1tm1Zqw
Genetic Background: 129S-Parp1tm1Zqw/J

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Parp1tm1Zqw/Parp1tm1Zqw
Genetic Background: 129S-Parp1tm1Zqw/J

 MP:0003691 abnormal microglial cell function "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Parp1tm1Zqw/Parp1tm1Zqw
Genetic Background: 129S-Parp1tm1Zqw/J

 MP:0003701 elevated level of sister chromatid exchange "increased number of crossovers between sister chromatids during meiosis resulting in increased numbers of reciprocal exchanges of DNA between the two chromosomes" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:97667]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd,Parp1tm1Zqw/Parp1tm1Zqw
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0003992 increased mortality induced by ionizing radiation "greater sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Msh2tm1Htr/Msh2tm1Htr
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm,Parp3tm1.2Ics/Parp3tm1.2Ics
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd,Parp1tm1Zqw/Parp1tm1Zqw
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0004030 induced chromosome breakage "chromosome breakage following treatment with a DNA-damaging agent " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004042 decreased susceptibility to kidney reperfusion injury "a diminished likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Parp1tm1Zqw/Parp1tm1Zqw
Genetic Background: 129S-Parp1tm1Zqw/J

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004925 decreased susceptibility to noise-induced hearing loss "less than normal reduction in hearing sensitivity following exposure to acute noise that is injurious to the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Parp1tm1Zqw/Parp1tm1Zqw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005527 increased glomerular filtration rate "greater than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Parp1tm1Zqw/Parp1tm1Zqw
Genetic Background: 129S-Parp1tm1Zqw/J

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Parp1tm1Zqw/Parp1tm1Zqw
Genetic Background: 129S-Parp1tm1Zqw/J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0008642 decreased circulating interleukin-1 beta level "reduction in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Oca2p-cp/Oca2p-cp
Genetic Background: Not Specified

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
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Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata6tm2Msp/Gata6tm2Msp,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Parp1tm1Zqw/Parp1tm1Zqw
Genetic Background: 129S-Parp1tm1Zqw/J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm,Parp2tm1Jmdm/Parp2tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd,Parp1tm1Zqw/Parp1tm1Zqw
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0011372 decreased renal tubule apoptosis "decrease in the number of renal tubule cells undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Parp1tm1Zqw/Parp1tm1Zqw
Genetic Background: 129S-Parp1tm1Zqw/J

 MP:0011452 decreased susceptibility to dopaminergic neuron neurotoxicity "less than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]
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Allelic Composition: Trp63tm2Brd/Trp63tm2Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
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Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020265 Sumo3 / Q9Z172 / small ubiquitin-like modifier 3 / P55854*  / reaction
 ENSMUSG00000031446 Cul4a / Q3TCH7 / Cullin-4A / Q13619*  / reaction / complex
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / reaction / complex
 ENSMUSG00000031095 Cul4b / A2A432 / Cullin-4B / Q13620*  / reaction / complex
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / complex / reaction
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / complex / reaction
 ENSMUSG00000024740 Ddb1 / Q3U1J4 / DNA damage-binding protein 1 / Q16531* / damage specific DNA binding protein 1*  / complex / reaction
 ENSMUSG00000024742 Fen1 / flap structure-specific endonuclease 1 / P39748*  / complex / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex / reaction
 ENSMUSG00000021911 Parg / O88622 / Poly(ADP-ribose) glycohydrolase / Q86W56*  / reaction
 ENSMUSG00000030094 Xpc / P51612 / xeroderma pigmentosum, complementation group C / Q01831* / XPC complex subunit, DNA damage recognition and repair factor*  / complex / reaction
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000031536 Polb / Q8K409 / polymerase (DNA directed), beta / P06746* / DNA polymerase beta*  / complex / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSMUSG00000028329 Xpa / Q64267 / xeroderma pigmentosum, complementation group A / P23025* / XPA, DNA damage recognition and repair factor*  / reaction / complex
 ENSMUSG00000031347 Cetn2 / Q9R1K9 / Centrin-2 / P41208*  / complex / reaction
 ENSMUSG00000026496 Parp1 / poly (ADP-ribose) polymerase family, member 1 / P09874* / poly(ADP-ribose) polymerase 1*  / complex
 ENSMUSG00000002109 Ddb2 / Q99J79 / DNA damage-binding protein 2 / Q92466* / damage specific DNA binding protein 2*  / complex / reaction
 ENSMUSG00000028426 P54728 / Rad23b / UV excision repair B / P54727* / RAD23 homolog B, nucleotide excision repair protein*  / complex / reaction
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / reaction / complex
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / reaction / complex
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction / complex
 ENSMUSG00000028089 Chd1l / Q9CXF7 / Chromodomain-helicase-DNA-binding protein 1-like / Q86WJ1*  / reaction / complex
 ENSMUSG00000041238 Rbbp8 / Q80YR6 / retinoblastoma binding protein 8, endonuclease / Q99708* / RB binding protein 8, endonuclease*  / complex / reaction
 ENSMUSG00000034206 Polq / Q8CGS6 / polymerase (DNA directed), theta / O75417* / DNA polymerase theta*  / complex / reaction
 ENSMUSG00000035960 Apex1 / P28352 / DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial / P27695* / apurinic/apyrimidinic endodeoxyribonuclease 1*  / reaction






 

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