ENSMUSG00000023249


Mus musculus

Features
Gene ID: ENSMUSG00000023249
  
Biological name :Parp3
  
Synonyms : Parp3 / poly(ADP-ribose) polymerase family member 3
  
Possible biological names infered from orthology : Q9Y6F1
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F1
Gene start: 106470322
Gene end: 106476949
  
Corresponding Affymetrix probe sets: 10596492 (MoGene1.0st)   1426210_x_at (Mouse Genome 430 2.0 Array)   1445888_x_at (Mouse Genome 430 2.0 Array)   1451969_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123054
Ensembl peptide - ENSMUSP00000117329
Ensembl peptide - ENSMUSP00000149572
Ensembl peptide - ENSMUSP00000119244
Ensembl peptide - ENSMUSP00000064513
Ensembl peptide - ENSMUSP00000108098
NCBI entrez gene - 235587     See in Manteia.
MGI - MGI:1891258
RefSeq - XM_006511720
RefSeq - XM_006511718
RefSeq - XM_006511719
RefSeq - NM_001311150
RefSeq - NM_145619
RefSeq Peptide - NP_663594
RefSeq Peptide - NP_001298079
swissprot - Q3ULW8
swissprot - Q8CFB8
swissprot - E9Q992
swissprot - A0A1L1SRP6
swissprot - E9PX17
Ensembl - ENSMUSG00000023249
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 parp3ENSDARG00000003961Danio rerio
 PARP3ENSGALG00000004517Gallus gallus
 PARP3ENSG00000041880Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Parp2 / O88554 / Poly [ADP-ribose] polymerase 2 / Q9UGN5*ENSMUSG0000003602333
Parp1 / poly (ADP-ribose) polymerase family, member 1 / P09874* / poly(ADP-ribose) polymerase 1*ENSMUSG0000002649631


Protein motifs (from Interpro)
Interpro ID Name
 IPR004102  Poly(ADP-ribose) polymerase, regulatory domain
 IPR008893  WGR domain
 IPR012317  Poly(ADP-ribose) polymerase, catalytic domain
 IPR031275  Poly [ADP-ribose] polymerase 3
 IPR036616  Poly(ADP-ribose) polymerase, regulatory domain superfamily
 IPR036930  WGR domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance ISO
 biological_processGO:0006273 lagging strand elongation IBA
 biological_processGO:0006302 double-strand break repair ISO
 biological_processGO:0006471 protein ADP-ribosylation ISO
 biological_processGO:0051103 DNA ligation involved in DNA repair IBA
 biological_processGO:0051106 positive regulation of DNA ligation ISO
 biological_processGO:0060236 regulation of mitotic spindle organization ISO
 biological_processGO:1990166 protein localization to site of double-strand break ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0035861 site of double-strand break ISO
 molecular_functionGO:0003910 DNA ligase (ATP) activity IBA
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003992 increased mortality induced by ionizing radiation "greater sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Myl2tm1(cre)Krc/Myl2+
Genetic Background: B6.Cg-Myl2tm1(cre)Krc Egln1tm1.1Brei

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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