ENSMUSG00000036023


Mus musculus

Features
Gene ID: ENSMUSG00000036023
  
Biological name :Parp2
  
Synonyms : O88554 / Parp2 / Poly [ADP-ribose] polymerase 2
  
Possible biological names infered from orthology : Q9UGN5
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: C1
Gene start: 50807841
Gene end: 50821301
  
Corresponding Affymetrix probe sets: 10414497 (MoGene1.0st)   1417800_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048877
Ensembl peptide - ENSMUSP00000153963
NCBI entrez gene - 11546     See in Manteia.
MGI - MGI:1341112
RefSeq - XM_006518442
RefSeq - NM_009632
RefSeq Peptide - NP_033762
swissprot - O88554
Ensembl - ENSMUSG00000036023
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 parp2ENSDARG00000079202Danio rerio
 PARP2ENSG00000129484Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Parp1 / poly (ADP-ribose) polymerase family, member 1 / P09874* / poly(ADP-ribose) polymerase 1*ENSMUSG0000002649638
Parp3 / poly(ADP-ribose) polymerase family member 3 / Q9Y6F1*ENSMUSG0000002324931


Protein motifs (from Interpro)
Interpro ID Name
 IPR004102  Poly(ADP-ribose) polymerase, regulatory domain
 IPR008893  WGR domain
 IPR012317  Poly(ADP-ribose) polymerase, catalytic domain
 IPR036616  Poly(ADP-ribose) polymerase, regulatory domain superfamily
 IPR036930  WGR domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006273 lagging strand elongation IBA
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006284 base-excision repair IMP
 biological_processGO:0006471 protein ADP-ribosylation IEA
 biological_processGO:0018312 peptidyl-serine ADP-ribosylation IEA
 biological_processGO:0051103 DNA ligation involved in DNA repair IBA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003910 DNA ligase (ATP) activity IBA
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:1990404 protein ADP-ribosylase activity IEA


Pathways (from Reactome)
Pathway description
POLB-Dependent Long Patch Base Excision Repair
HDR through MMEJ (alt-NHEJ)
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm,Parp2tm1Jmdm/Parp2tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0003701 elevated level of sister chromatid exchange "increased number of crossovers between sister chromatids during meiosis resulting in increased numbers of reciprocal exchanges of DNA between the two chromosomes" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:97667]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0004030 induced chromosome breakage "chromosome breakage following treatment with a DNA-damaging agent " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Parp1tm1Jmdm/Parp1tm1Jmdm,Parp2tm1Jmdm/Parp2tm1Jmdm
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Lmnatm2Stw/Lmnatm2Stw
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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