ENSG00000129484


Homo sapiens

Features
Gene ID: ENSG00000129484
  
Biological name :PARP2
  
Synonyms : PARP2 / poly(ADP-ribose) polymerase 2 / Q9UGN5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q11.2
Gene start: 20343582
Gene end: 20357905
  
Corresponding Affymetrix probe sets: 204752_x_at (Human Genome U133 Plus 2.0 Array)   214086_s_at (Human Genome U133 Plus 2.0 Array)   215773_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000250416
Ensembl peptide - ENSP00000431867
Ensembl peptide - ENSP00000432283
Ensembl peptide - ENSP00000445524
Ensembl peptide - ENSP00000392972
NCBI entrez gene - 10038     See in Manteia.
OMIM - 607725
RefSeq - XM_017020912
RefSeq - NM_001042618
RefSeq - NM_005484
RefSeq - XM_005267247
RefSeq Peptide - NP_001036083
RefSeq Peptide - NP_005475
swissprot - E9PJ27
swissprot - G3V167
swissprot - H0YH02
swissprot - Q9UGN5
Ensembl - ENSG00000129484
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 parp2ENSDARG00000079202Danio rerio
 Parp2ENSMUSG00000036023Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PARP1 / P09874 / poly(ADP-ribose) polymerase 1ENSG0000014379937
PARP3 / Q9Y6F1 / poly(ADP-ribose) polymerase family member 3ENSG0000004188031


Protein motifs (from Interpro)
Interpro ID Name
 IPR004102  Poly(ADP-ribose) polymerase, regulatory domain
 IPR008893  WGR domain
 IPR012317  Poly(ADP-ribose) polymerase, catalytic domain
 IPR036616  Poly(ADP-ribose) polymerase, regulatory domain superfamily
 IPR036930  WGR domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006273 lagging strand elongation IBA
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006471 protein ADP-ribosylation IEA
 biological_processGO:0018312 peptidyl-serine ADP-ribosylation IDA
 biological_processGO:0051103 DNA ligation involved in DNA repair IBA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003910 DNA ligase (ATP) activity IBA
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:1990404 protein ADP-ribosylase activity IDA


Pathways (from Reactome)
Pathway description
POLB-Dependent Long Patch Base Excision Repair
HDR through MMEJ (alt-NHEJ)
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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