ENSG00000143799


Homo sapiens

Features
Gene ID: ENSG00000143799
  
Biological name :PARP1
  
Synonyms : P09874 / PARP1 / poly(ADP-ribose) polymerase 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q42.12
Gene start: 226360691
Gene end: 226408079
  
Corresponding Affymetrix probe sets: 208644_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000355757
Ensembl peptide - ENSP00000485852
Ensembl peptide - ENSP00000355759
Ensembl peptide - ENSP00000355755
NCBI entrez gene - 142     See in Manteia.
OMIM - 173870
RefSeq - NM_001618
RefSeq Peptide - NP_001609
swissprot - A0A024R3T8
swissprot - P09874
swissprot - Q5VX84
swissprot - Q5VX85
Ensembl - ENSG00000143799
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 parp1ENSDARG00000019529Danio rerio
 PARP1ENSGALG00000009228Gallus gallus
 Parp1ENSMUSG00000026496Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PARP2 / Q9UGN5 / poly(ADP-ribose) polymerase 2ENSG0000012948421
PARP3 / Q9Y6F1 / poly(ADP-ribose) polymerase family member 3ENSG0000004188016


Protein motifs (from Interpro)
Interpro ID Name
 IPR001357  BRCT domain
 IPR001510  Zinc finger, PARP-type
 IPR004102  Poly(ADP-ribose) polymerase, regulatory domain
 IPR008288  Poly [ADP-ribose] polymerase
 IPR008893  WGR domain
 IPR012317  Poly(ADP-ribose) polymerase, catalytic domain
 IPR012982  PADR1 domain
 IPR036420  BRCT domain superfamily
 IPR036616  Poly(ADP-ribose) polymerase, regulatory domain superfamily
 IPR036930  WGR domain superfamily
 IPR036957  Zinc finger, PARP-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0000715 nucleotide-excision repair, DNA damage recognition TAS
 biological_processGO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS
 biological_processGO:0000723 telomere maintenance TAS
 biological_processGO:0000724 double-strand break repair via homologous recombination TAS
 biological_processGO:0006273 lagging strand elongation IBA
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006293 nucleotide-excision repair, preincision complex stabilization TAS
 biological_processGO:0006294 nucleotide-excision repair, preincision complex assembly TAS
 biological_processGO:0006295 nucleotide-excision repair, DNA incision, 3"-to lesion TAS
 biological_processGO:0006296 nucleotide-excision repair, DNA incision, 5"-to lesion TAS
 biological_processGO:0006302 double-strand break repair IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006471 protein ADP-ribosylation TAS
 biological_processGO:0006915 apoptotic process IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0010332 response to gamma radiation IEA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy ISS
 biological_processGO:0010990 regulation of SMAD protein complex assembly IEA
 biological_processGO:0016540 protein autoprocessing IEA
 biological_processGO:0018312 peptidyl-serine ADP-ribosylation IDA
 biological_processGO:0023019 signal transduction involved in regulation of gene expression IEA
 biological_processGO:0030225 macrophage differentiation TAS
 biological_processGO:0032042 mitochondrial DNA metabolic process IMP
 biological_processGO:0032869 cellular response to insulin stimulus IDA
 biological_processGO:0033148 positive regulation of intracellular estrogen receptor signaling pathway IEA
 biological_processGO:0033683 nucleotide-excision repair, DNA incision TAS
 biological_processGO:0034599 cellular response to oxidative stress IMP
 biological_processGO:0034644 cellular response to UV IMP
 biological_processGO:0036211 protein modification process IMP
 biological_processGO:0042769 DNA damage response, detection of DNA damage IEA
 biological_processGO:0043504 mitochondrial DNA repair IMP
 biological_processGO:0044030 regulation of DNA methylation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0050790 regulation of catalytic activity IDA
 biological_processGO:0051103 DNA ligation involved in DNA repair IBA
 biological_processGO:0051901 positive regulation of mitochondrial depolarization IEA
 biological_processGO:0060391 positive regulation of SMAD protein signal transduction IEA
 biological_processGO:0070212 protein poly-ADP-ribosylation IDA
 biological_processGO:0070911 global genome nucleotide-excision repair TAS
 biological_processGO:0071294 cellular response to zinc ion IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:1900182 positive regulation of protein localization to nucleus IEA
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1903376 regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903518 positive regulation of single strand break repair IGI
 biological_processGO:1903827 regulation of cellular protein localization IMP
 biological_processGO:1904044 response to aldosterone IEA
 biological_processGO:1904357 negative regulation of telomere maintenance via telomere lengthening ISS
 biological_processGO:1904646 cellular response to amyloid-beta IEA
 biological_processGO:1904762 positive regulation of myofibroblast differentiation IEA
 biological_processGO:1990966 ATP generation from poly-ADP-D-ribose IDA
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding IEA
 biological_processGO:2001170 negative regulation of ATP biosynthetic process IMP
 cellular_componentGO:0000784 nuclear chromosome, telomeric region HDA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0032993 protein-DNA complex IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003910 DNA ligase (ATP) activity IBA
 molecular_functionGO:0003950 NAD+ ADP-ribosyltransferase activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030331 estrogen receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IPI
 molecular_functionGO:0051287 NAD binding IEA
 molecular_functionGO:0070412 R-SMAD binding IEA
 molecular_functionGO:1990404 protein ADP-ribosylase activity IDA


Pathways (from Reactome)
Pathway description
POLB-Dependent Long Patch Base Excision Repair
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SUMOylation of DNA damage response and repair proteins
HDR through MMEJ (alt-NHEJ)
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000051341 POLQ / O75417 / DNA polymerase theta  / complex / reaction
 ENSG00000168496 FEN1 / P39748 / flap structure-specific endonuclease 1  / reaction / complex
 ENSG00000167986 DDB1 / Q16531 / damage specific DNA binding protein 1  / complex / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000147400 CETN2 / P41208 / centrin 2  / complex / reaction
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / complex / reaction
 ENSG00000101773 RBBP8 / Q99708 / RB binding protein 8, endonuclease  / complex / reaction
 ENSG00000184900 SUMO3 / P55854 / small ubiquitin-like modifier 3  / reaction
 ENSG00000154767 XPC / Q01831 / XPC complex subunit, DNA damage recognition and repair factor  / complex / reaction
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / complex / reaction
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / reaction
 ENSG00000134574 DDB2 / Q92466 / damage specific DNA binding protein 2  / reaction / complex
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / complex / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex / reaction
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex / reaction
 ENSG00000100823 APEX1 / P27695 / apurinic/apyrimidinic endodeoxyribonuclease 1  / reaction
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / complex / reaction
 ENSG00000143799 PARP1 / P09874 / poly(ADP-ribose) polymerase 1  / complex
 ENSG00000070501 POLB / P06746 / DNA polymerase beta  / reaction / complex
 ENSG00000119318 P54727 / RAD23B / RAD23 homolog B, nucleotide excision repair protein  / complex / reaction
 ENSG00000158290 CUL4B / Q13620 / cullin 4B  / reaction / complex
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / complex / reaction
 ENSG00000131778 CHD1L / Q86WJ1 / chromodomain helicase DNA binding protein 1 like  / reaction / complex
 ENSG00000104320 NBN / nibrin / O60934  / reaction / complex
 ENSG00000139842 CUL4A / Q13619 / cullin 4A  / reaction / complex
 ENSG00000136936 XPA / P23025 / XPA, DNA damage recognition and repair factor  / complex / reaction
 ENSG00000227345 PARG / Q86W56 / poly(ADP-ribose) glycohydrolase  / reaction






 

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