ENSG00000184900


Homo sapiens

Features
Gene ID: ENSG00000184900
  
Biological name :SUMO3
  
Synonyms : P55854 / small ubiquitin-like modifier 3 / SUMO3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: -1
Band: q22.3
Gene start: 44805617
Gene end: 44818779
  
Corresponding Affymetrix probe sets: 200739_s_at (Human Genome U133 Plus 2.0 Array)   200740_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000380990
Ensembl peptide - ENSP00000409666
Ensembl peptide - ENSP00000380995
Ensembl peptide - ENSP00000330343
NCBI entrez gene - 6612     See in Manteia.
OMIM - 602231
RefSeq - NM_006936
RefSeq - NM_001286416
RefSeq Peptide - NP_001273345
RefSeq Peptide - NP_008867
swissprot - P55854
swissprot - A8MUA9
swissprot - A8MU27
Ensembl - ENSG00000184900
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6NV25ENSDARG00000028119Danio rerio
 sumo3bENSDARG00000035993Danio rerio
 SUMO3ENSGALG00000032783Gallus gallus
 Sumo3ENSMUSG00000020265Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SUMO2 / P61956 / small ubiquitin-like modifier 2ENSG0000018861265
SUMO4 / Q6EEV6 / small ubiquitin-like modifier 4ENSG0000017768855
SUMO1 / P63165 / small ubiquitin-like modifier 1ENSG0000011603035


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR022617  Rad60/SUMO-like domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR033950  Sumo domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016925 protein sumoylation TAS
 biological_processGO:0043392 negative regulation of DNA binding IDA
 biological_processGO:0070911 global genome nucleotide-excision repair TAS
 cellular_componentGO:0000776 kinetochore TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0031386 protein tag IBA


Pathways (from Reactome)
Pathway description
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is proteolytically processed
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of transcription cofactors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of DNA replication proteins
SUMOylation of immune response proteins
Formation of Incision Complex in GG-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000126261 UBA2 / Q9UBT2 / ubiquitin like modifier activating enzyme 2  / complex / reaction
 ENSG00000139372 TDG / Q13569 / thymine DNA glycosylase  / reaction
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / reaction
 ENSG00000160633 SAFB / Q15424 / scaffold attachment factor B  / reaction
 ENSG00000163904 SENP2 / Q9HC62 / SUMO1/sentrin/SMT3 specific peptidase 2  / reaction
 ENSG00000142230 SAE1 / Q9UBE0 / SUMO1 activating enzyme subunit 1  / complex / reaction
 ENSG00000159692 CTBP1 / Q13363 / C-terminal binding protein 1  / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction
 ENSG00000126351 THRA / P10827 / thyroid hormone receptor, alpha  / reaction
 ENSG00000068024 HDAC4 / P56524 / histone deacetylase 4  / reaction
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / - / reaction
 ENSG00000025434 NR1H3 / Q13133 / nuclear receptor subfamily 1 group H member 3  / reaction
 ENSG00000151090 THRB / P10828 / thyroid hormone receptor beta  / reaction
 ENSG00000154767 XPC / Q01831 / XPC complex subunit, DNA damage recognition and repair factor  / complex
 ENSG00000181163 NPM1 / P06748 / nucleophosmin 1  / reaction
 ENSG00000140464 PML / P29590 / promyelocytic leukemia  / reaction
 ENSG00000131408 NR1H2 / P55055 / nuclear receptor subfamily 1 group H member 2  / reaction
 ENSG00000184900 SUMO3 / P55854 / small ubiquitin-like modifier 3  / - / reaction
 ENSG00000119042 SATB2 / Q9UPW6 / SATB homeobox 2  / reaction
 ENSG00000182979 MTA1 / Q13330 / metastasis associated 1  / reaction
 ENSG00000197299 BLM / P54132 / Bloom syndrome RecQ like helicase  / reaction
 ENSG00000144852 NR1I2 / O75469 / nuclear receptor subfamily 1 group I member 2  / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction / complex
 ENSG00000131747 TOP2A / P11388 / DNA topoisomerase II alpha  / reaction
 ENSG00000173039 RELA / Q04206 / RELA proto-oncogene, NF-kB subunit  / reaction
 ENSG00000153234 NR4A2 / P43354 / nuclear receptor subfamily 4 group A member 2  / reaction
 ENSG00000182568 SATB1 / Q01826 / SATB homeobox 1  / reaction
 ENSG00000119231 SENP5 / Q96HI0 / SUMO1/sentrin specific peptidase 5  / reaction
 ENSG00000012048 BRCA1 / P38398 / BRCA1, DNA repair associated  / reaction
 ENSG00000119318 P54727 / RAD23B / RAD23 homolog B, nucleotide excision repair protein  / complex
 ENSG00000143799 PARP1 / P09874 / poly(ADP-ribose) polymerase 1  / reaction
 ENSG00000147400 CETN2 / P41208 / centrin 2  / complex / reaction
 ENSG00000137337 MDC1 / Q14676 / mediator of DNA damage checkpoint 1  / reaction
 ENSG00000079387 SENP1 / Q9P0U3 / SUMO1/sentrin specific peptidase 1  / reaction






 

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