ENSG00000131747


Homo sapiens

Features
Gene ID: ENSG00000131747
  
Biological name :TOP2A
  
Synonyms : DNA topoisomerase II alpha / P11388 / TOP2A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.2
Gene start: 40388516
Gene end: 40417950
  
Corresponding Affymetrix probe sets: 201291_s_at (Human Genome U133 Plus 2.0 Array)   201292_at (Human Genome U133 Plus 2.0 Array)   237469_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000411532
Ensembl peptide - ENSP00000462908
Ensembl peptide - ENSP00000464055
NCBI entrez gene - 7153     See in Manteia.
OMIM - 126430
RefSeq - XM_011525165
RefSeq - NM_001067
RefSeq - XM_005257632
RefSeq Peptide - NP_001058
swissprot - P11388
swissprot - J3QR57
swissprot - J3KTB7
Ensembl - ENSG00000131747
  
Related genetic diseases (OMIM): 126430 - DNA topoisomerase II, resistance to inhibition of, by amsacrine
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 top2aENSDARG00000024488Danio rerio
 TOP2AENSGALG00000003922Gallus gallus
 Top2aENSMUSG00000020914Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TOP2B / Q02880 / DNA topoisomerase II betaENSG0000007709770


Protein motifs (from Interpro)
Interpro ID Name
 IPR001154  DNA topoisomerase II, eukaryotic-type
 IPR001241  DNA topoisomerase, type IIA
 IPR002205  DNA topoisomerase, type IIA, subunit A/C-terminal
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR006171  TOPRIM domain
 IPR012542  DTHCT
 IPR013506  DNA topoisomerase, type IIA, subunit B, domain 2
 IPR013757  Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily
 IPR013758  DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
 IPR013759  DNA topoisomerase, type IIA, subunit B, C-terminal
 IPR013760  DNA topoisomerase, type IIA-like domain superfamily
 IPR014721  Ribosomal protein S5 domain 2-type fold, subgroup
 IPR018522  DNA topoisomerase, type IIA, conserved site
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR031660  C-terminal associated domain of TOPRIM
 IPR034157  DNA topoisomerase 2, TOPRIM domain
 IPR036890  Histidine kinase/HSP90-like ATPase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000712 resolution of meiotic recombination intermediates IBA
 biological_processGO:0000819 sister chromatid segregation IBA
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0006265 DNA topological change IEA
 biological_processGO:0006266 DNA ligation IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0016925 protein sumoylation TAS
 biological_processGO:0030261 chromosome condensation IEA
 biological_processGO:0030263 apoptotic chromosome condensation IDA
 biological_processGO:0040016 embryonic cleavage IEA
 biological_processGO:0042752 regulation of circadian rhythm IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0044774 mitotic DNA integrity checkpoint IBA
 biological_processGO:0045070 positive regulation of viral genome replication IMP
 biological_processGO:0045870 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:1905463 negative regulation of DNA duplex unwinding IMP
 cellular_componentGO:0000228 nuclear chromosome IDA
 cellular_componentGO:0000793 condensed chromosome IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005814 centriole IDA
 cellular_componentGO:0009330 DNA topoisomerase complex (ATP-hydrolyzing) IDA
 cellular_componentGO:0019035 viral integration complex NAS
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003916 DNA topoisomerase activity IEA
 molecular_functionGO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity IEA
 molecular_functionGO:0005080 protein kinase C binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0008094 DNA-dependent ATPase activity IDA
 molecular_functionGO:0008144 drug binding IDA
 molecular_functionGO:0008301 DNA binding, bending IDA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0043130 ubiquitin binding IMP
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Transcription of E2F targets under negative control by DREAM complex
SUMOylation of DNA replication proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0004375 Neoplasia of the nervous system 
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 HP:0011976 Elevated urinary catecholamines "An increased concentration of `catecholamine` (CHEBI:33567) in the urine." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000184900 SUMO3 / P55854 / small ubiquitin-like modifier 3  / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction / complex






 

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