ENSDARG00000024488


Danio rerio

Features
Gene ID: ENSDARG00000024488
  
Biological name :top2a
  
Synonyms : DNA topoisomerase II alpha / top2a
  
Possible biological names infered from orthology : DNA topoisomerase 2-alpha / P11388 / Q01320
  
Species: Danio rerio
  
Chr. number: 12
Strand: 1
Band:
Gene start: 10706772
Gene end: 10740236
  
Corresponding Affymetrix probe sets: Dr.4412.19.S1_s_at (Zebrafish Array)   Dr.5418.1.S1_at (Zebrafish Array)   Dr.5418.2.S1_at (Zebrafish Array)   DrAffx.2.96.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000096930
Ensembl peptide - ENSDARP00000139353
NCBI entrez gene - 323733     See in Manteia.
RefSeq - NM_001310015
RefSeq Peptide - NP_001296944
swissprot - A8E7K3
swissprot - A0A0R4IUF0
swissprot - A0A0R4IEZ8
ZFIN ID - ZDB-GENE-030131-2453
Ensembl - ENSDARG00000024488
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TOP2AENSGALG00000003922Gallus gallus
 TOP2AENSG00000131747Homo sapiens
 Top2aENSMUSG00000020914Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
top2b / DNA topoisomerase II beta / Q02880* / Q64511* / DNA topoisomerase 2-beta *ENSDARG0000003419565


Protein motifs (from Interpro)
Interpro ID Name
 IPR001154  DNA topoisomerase II, eukaryotic-type
 IPR001241  DNA topoisomerase, type IIA
 IPR002205  DNA topoisomerase, type IIA, subunit A/C-terminal
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR006171  TOPRIM domain
 IPR012542  DTHCT
 IPR013506  DNA topoisomerase, type IIA, subunit B, domain 2
 IPR013757  Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily
 IPR013758  DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta
 IPR013759  DNA topoisomerase, type IIA, subunit B, C-terminal
 IPR013760  DNA topoisomerase, type IIA-like domain superfamily
 IPR014721  Ribosomal protein S5 domain 2-type fold, subgroup
 IPR018522  DNA topoisomerase, type IIA, conserved site
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR031660  C-terminal associated domain of TOPRIM
 IPR034157  DNA topoisomerase 2, TOPRIM domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000712 resolution of meiotic recombination intermediates IBA
 biological_processGO:0000819 sister chromatid segregation IBA
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0006265 DNA topological change IEA
 biological_processGO:0007059 chromosome segregation IMP
 biological_processGO:0031100 animal organ regeneration IMP
 biological_processGO:0044774 mitotic DNA integrity checkpoint IBA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003916 DNA topoisomerase activity IEA
 molecular_functionGO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016853 isomerase activity IEA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA replication proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain necrotic , abnormal
brain apoptotic , abnormal
Show

 ZFA:0000012 central nervous system central nervous system hemorrhagic , abnormal
central nervous system necrotic , abnormal
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 ZFA:0000035 lens lens necrotic , abnormal
lens protruding out of eye , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000084 yolk yolk quality , abnormal
yolk circular , abnormal
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 ZFA:0000106 extension extension decreased thickness , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye necrotic , abnormal
Show

 ZFA:0000109 forebrain forebrain atrophied , abnormal
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 ZFA:0000114 heart heart edematous , abnormal
Show

 ZFA:0000123 liver liver regenerating tissue hypoplastic , abnormal
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 ZFA:0000128 midbrain midbrain atrophied , abnormal
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 ZFA:0000152 retina retina necrotic , abnormal
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 ZFA:0000396 nervous system nervous system quality , abnormal
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 ZFA:0001094 whole organism whole organism nucleus attached to whole organism nucleus, abnormal
whole organism ploidy , abnormal
whole organism polyploid , abnormal
whole organism aneuploid , abnormal
whole organism condensed chromosome spatial pattern , abnormal
whole organism condensed chromosome tangled , abnormal
whole organism viability , abnormal
whole organism curved dorsal , abnormal
whole organism shape , abnormal
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 ZFA:0001114 head head malformed , abnormal
Show

 ZFA:0001115 trunk trunk decreased thickness , abnormal
trunk atrophied , abnormal
trunk curved dorsal , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
post-vent region spindle positional polarity , abnormal
post-vent region curved dorsal , abnormal
Show

 ZFA:0001135 neural tube neural tube apoptotic , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000035993 sumo3b / small ubiquitin-like modifier 3b / SUMO3* / P55854* / small ubiquitin-like modifier 3*  / reaction
 ENSDARG00000102741 sumo2b / Q6DHL4 / small ubiquitin-like modifier 2b / SUMO4* / SUMO2* / Q6EEV6* / P61956* / P61957* / small ubiquitin-like modifier 4* / small ubiquitin-like modifier 2*  / reaction
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex / reaction
 ENSDARG00000028119 Q6NV25 / sumo3a / small ubiquitin-like modifier 3a / SUMO3* / Q9Z172* / P55854* / small ubiquitin-like modifier 3*  / reaction






 

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