ENSDARG00000044267


Danio rerio

Features
Gene ID: ENSDARG00000044267
  
Biological name :sumo1
  
Synonyms : Q7SZR5 / small ubiquitin-like modifier 1 / sumo1
  
Possible biological names infered from orthology : P63165 / P63166 / Small ubiquitin-related modifier 1
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 9677420
Gene end: 9688511
  
Corresponding Affymetrix probe sets: Dr.5426.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000064994
NCBI entrez gene - 406438     See in Manteia.
RefSeq - NM_213159
RefSeq Peptide - NP_998324
swissprot - Q7SZR5
ZFIN ID - ZDB-GENE-040426-2186
Ensembl - ENSDARG00000044267
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SUMO1ENSGALG00000008435Gallus gallus
 SUMO1ENSG00000116030Homo sapiens
 Sumo1ENSMUSG00000026021Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sumo2b / Q6DHL4 / small ubiquitin-like modifier 2b / SUMO4* / SUMO2* / Q6EEV6* / P61956* / P61957* / small ubiquitin-like modifier 4* / small ubiquitin-like modifier 2*ENSDARG0000010274149
sumo3b / small ubiquitin-like modifier 3b / SUMO3* / P55854* / small ubiquitin-like modifier 3*ENSDARG0000003599348
Q6NV25 / sumo3a / small ubiquitin-like modifier 3a / SUMO3* / Q9Z172* / P55854* / small ubiquitin-like modifier 3*ENSDARG0000002811947
sumo2a / small ubiquitin-like modifier 2aENSDARG0000010439043


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR022617  Rad60/SUMO-like domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR033950  Sumo domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016925 protein sumoylation IBA
 biological_processGO:0034605 cellular response to heat ISS
 biological_processGO:0043009 chordate embryonic development IGI
 biological_processGO:0060216 definitive hemopoiesis IGI
 biological_processGO:0071276 cellular response to cadmium ion ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0097165 nuclear stress granule ISS
 molecular_functionGO:0031386 protein tag IBA


Pathways (from Reactome)
Pathway description
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is proteolytically processed
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
G2/M DNA damage checkpoint
Regulation of IFNG signaling
Negative regulation of activity of TFAP2 (AP-2) family transcription factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000000151 thraa / Q98867 / thyroid hormone receptor alpha a / THRA* / P63058* / P10827* / thyroid hormone receptor, alpha*  / reaction / complex
 ENSDARG00000076182 stat1b / signal transducer and activator of transcription 1b / STAT1* / P42224* / signal transducer and activator of transcription 1*  / reaction / complex
 ENSDARG00000002385 atm / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / complex / reaction
 ENSDARG00000017037 ikbkg / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma / Q9Y6K9* / O88522* / NF-kappa-B essential modulator * / inhibitor of nuclear factor kappa B kinase subunit gamma*  / complex / reaction
 ENSDARG00000010487 sae1 / Q6IQS6 / SUMO1 activating enzyme subunit 1 / Q9UBE0* / Q9R1T2* / SUMO-activating enzyme subunit 1 SUMO-activating enzyme subunit 1, N-terminally processed*  / complex / reaction
 ENSDARG00000037833 mitfb / microphthalmia-associated transcription factor b / MITF* / O75030* / melanogenesis associated transcription factor*  / complex
 ENSDARG00000026225 nsd2 / nuclear receptor binding SET domain protein 2 / O96028* / Q8BVE8* / Histone-lysine N-methyltransferase NSD2 *  / complex / reaction
 ENSDARG00000021163 thrb / Q9PVE4 / thyroid hormone receptor beta / P10828* / P37242*  / reaction / complex
 ENSDARG00000019529 parp1 / poly (ADP-ribose) polymerase 1 / P09874* / poly (ADP-ribose) polymerase family, member 1*  / complex / reaction
 ENSDARG00000030756 dnmt1 / DNA (cytosine-5-)-methyltransferase 1 / P26358* / DNA methyltransferase 1*  / reaction / complex
 ENSDARG00000005274 rad52 / RAD52 homolog, DNA repair protein / P43351* / P43352*  / complex / reaction
 ENSDARG00000010732 xrcc4 / X-ray repair complementing defective repair in Chinese hamster cells 4 / Q13426* / X-ray repair cross complementing 4*  / complex / reaction
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction / complex
 ENSDARG00000008748 ube2na / ubiquitin-conjugating enzyme E2Na / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / reaction / complex
 ENSDARG00000004111 esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor *  / reaction / complex
 ENSDARG00000005481 nfkbiaa / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a / Q9Z1E3* / NFKBIA* / P25963* / NFKB inhibitor alpha* / NF-kappa-B inhibitor alpha *  / complex / reaction
 ENSDARG00000007693 nfkbiab / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b / Q9Z1E3* / NFKBIA* / P25963* / NFKB inhibitor alpha* / NF-kappa-B inhibitor alpha *  / reaction / complex
 ENSDARG00000019103 kdm4ab / lysine (K)-specific demethylase 4A, genome duplicate b / KDM4A* / O75164* / Q8BW72* / AL451062.3* / lysine demethylase 4A* / Lysine-specific demethylase 4A *  / complex / reaction
 ENSDARG00000036094 pias1a / protein inhibitor of activated STAT, 1a / PIAS1* / O88907* / O75925* / protein inhibitor of activated STAT 1*  / reaction / complex
 ENSDARG00000028198 Q6PEH5 / ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / reaction / complex
 ENSDARG00000018257 ncoa1 / nuclear receptor coactivator 1 / P70365* / Q15788*  / complex / reaction
 ENSDARG00000015427 hdac1 / histone deacetylase 1 / O09106* / Q13547* / Gm10093*  / complex / reaction
 ENSDARG00000090449 sp100.3 / SP110 nuclear body protein, tandem duplicate 3 / SP110* / SP140* / SP100* / SP140L* / Q9H930* / O35892* / P23497* / Q13342* / Q8BVK9* / Q9HB58* / A630001G21Rik* / A530032D15Rik* /...  / reaction / complex
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex / reaction
 ENSDARG00000102741 sumo2b / Q6DHL4 / small ubiquitin-like modifier 2b / SUMO4* / SUMO2* / Q6EEV6* / P61956* / P61957* / small ubiquitin-like modifier 4* / small ubiquitin-like modifier 2*  / complex / reaction
 ENSDARG00000079716 sin3aa / SIN3 transcription regulator family member Aa / SIN3A* / Q96ST3* / Q60520* / SIN3 transcription regulator family member A* / Mus musculus transcriptional regulator, SIN3A (yeast) (...  / reaction / complex
 ENSDARG00000086764 mdc1 / mediator of DNA damage checkpoint 1 / Q14676*  / reaction / complex
 ENSDARG00000031777 pparaa / peroxisome proliferator-activated receptor alpha a / PPARA* / P23204* / Q07869* / peroxisome proliferator activated receptor alpha*  / reaction / complex
 ENSDARG00000099675 kdm4b / lysine (K)-specific demethylase 4B / O94953* / Q91VY5* / lysine demethylase 4B* / Lysine-specific demethylase 4B *  / reaction / complex
 ENSDARG00000010873 si:dkey-156n14.5 / DDX17* / Q92841* / DEAD-box helicase 17*  / reaction / complex
 ENSDARG00000045877 ube2nb / ubiquitin-conjugating enzyme E2Nb / UBE2N* / P61089* / UBE2NL* / P61088* / ubiquitin conjugating enzyme E2 N* / ubiquitin conjugating enzyme E2 N like (gene/pseudogene)*  / complex / reaction
 ENSDARG00000101332 uba2 / Q7SXG4 / ubiquitin-like modifier activating enzyme 2 / Q9UBT2* / Q9Z1F9*  / complex / reaction
 ENSDARG00000105014 mre11a / MRE11 homolog A, double strand break repair nuclease / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSDARG00000044949 rnf8 / ring finger protein 8, E3 ubiquitin protein ligase / Q8VC56* / O76064* / Gm28043* / ring finger protein 8* / E3 ubiquitin-protein ligase RNF8 *  / reaction / complex
 ENSDARG00000040303 nbn / nibrin / Q5I2W8 / O60934* / Q9R207*  / complex / reaction
 ENSDARG00000101510 cetn2 / centrin, EF-hand protein, 2 / CETN1* / Q9R1K9* / P41209* / Q12798* / P41208* / centrin 2* / centrin 1*  / complex
 ENSDARG00000055359 sp100.1 / SP110 nuclear body protein, tandem duplicate 1 / SP110* / SP140* / SP100* / SP140L* / Q9H930* / O35892* / P23497* / Q13342* / Q8BVK9* / Q9HB58* / A630001G21Rik* / A530032D15Rik* /...  / reaction / complex
 ENSDARG00000104907 ing2 / inhibitor of growth family, member 2 / Q9ESK4* / Q9H160* / Inhibitor of growth protein 2 *  / reaction / complex
 ENSDARG00000045704 Q5RGE5 / dclre1c / DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) / Q96SD1* / Q8K4J0* / Protein artemis * / DNA cross-link repair 1C*  / complex / reaction
 ENSDARG00000039754 xpc / xeroderma pigmentosum, complementation group C / P51612* / Q01831* / XPC complex subunit, DNA damage recognition and repair factor*  / complex / reaction
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction / complex
 ENSDARG00000091187 BX649250.1 / UIMC1* / Q96RL1* / ubiquitin interaction motif containing 1*  / complex / reaction
 ENSDARG00000018782 kdm4aa / lysine (K)-specific demethylase 4A, genome duplicate a / KDM4A* / O75164* / Q8BW72* / AL451062.3* / lysine demethylase 4A* / Lysine-specific demethylase 4A *  / reaction / complex
 ENSDARG00000014329 npm1a / nucleophosmin 1a / NPM1* / Q61937* / P06748* / nucleophosmin 1*  / complex / reaction
 ENSDARG00000042215 pias4b / protein inhibitor of activated STAT, 4b / PIAS4* / Q9JM05* / Q8N2W9* / protein inhibitor of activated STAT 4*  / reaction / complex
 ENSDARG00000038917 rad50 / RAD50 homolog, double strand break repair protein / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / reaction / complex
 ENSDARG00000038687 nfkb2 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) / Q00653* / Q9WTK5* / nuclear factor kappa B subunit 2*  / complex / reaction
 ENSDARG00000059812 sin3ab / SIN3 transcription regulator family member Ab / SIN3A* / Q96ST3* / Q60520* / SIN3 transcription regulator family member A* / Mus musculus transcriptional regulator, SIN3A (yeast) (...  / reaction / complex
 ENSDARG00000100940 nr5a2 / nuclear receptor subfamily 5, group A, member 2 / O00482*  / reaction / complex
 ENSDARG00000005606 paxip1 / PAX interacting (with transcription-activation domain) protein 1 / Q6NZQ4* / Q6ZW49* / PAX interacting protein 1*  / complex
 ENSDARG00000054323 pparab / peroxisome proliferator-activated receptor alpha b / PPARA* / P23204* / Q07869* / peroxisome proliferator activated receptor alpha*  / reaction / complex
 ENSDARG00000098924 suz12b / B0R1D5 / SUZ12 polycomb repressive complex 2b subunit / SUZ12* / Q80U70* / Q15022* / Polycomb protein Suz12 * / SUZ12 polycomb repressive complex 2 subunit*  / complex / reaction
 ENSDARG00000067976 ar / androgen receptor / P10275* / P19091*  / complex / reaction
 ENSDARG00000025032 nr3c1 / nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) / P04150* / nuclear receptor subfamily 3 group C member 1*  / reaction / complex
 ENSDARG00000019213 zgc:136929 / CTBP1* / O88712* / Q13363* / C-terminal binding protein 1*  / reaction / complex
 ENSDARG00000073841 herc2 / HECT and RLD domain containing E3 ubiquitin protein ligase 2 / O95714* / Q4U2R1* / E3 ubiquitin-protein ligase HERC2 *  / reaction / complex
 ENSDARG00000021550 rad23b / RAD23 homolog B, nucleotide excision repair protein / P54727*  / complex
 ENSDARG00000057737 rxraa / retinoid X receptor, alpha a / RXRA* / P19793* / P28700* / retinoid X receptor alpha*  / reaction / complex
 ENSDARG00000060646 senp5 / SUMO1/sentrin specific peptidase 5 / Q6NXL6* / Q96HI0* / Sentrin-specific protease 5 *  / reaction
 ENSDARG00000003732 mitfa / microphthalmia-associated transcription factor a / MITF* / O75030* / Q08874* / melanogenesis associated transcription factor*  / complex
 ENSDARG00000070606 ikbke / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon / Q14164* / Q9R0T8* / inhibitor of nuclear factor kappa B kinase subunit epsilon*  / complex / reaction
 ENSDARG00000006010 bmi1a / bmi1 polycomb ring finger oncogene 1a / BMI1* / P35226* / P25916* / COMMD3-BMI1* / COMMD3-BMI1 readthrough* / Polycomb complex protein BMI-1 * / BMI1 proto-oncogene, polycomb ring finger*  / complex
 ENSDARG00000062445 pias1b / protein inhibitor of activated STAT, 1b / PIAS1* / O88907* / O75925* / protein inhibitor of activated STAT 1*  / complex / reaction
 ENSDARG00000055493 hic1 / hypermethylated in cancer 1 / Q14526* / HIC ZBTB transcriptional repressor 1*  / reaction / complex
 ENSDARG00000042180 foxl2a / forkhead box L2a / FOXL2* / O88470* / P58012* / forkhead box L2* / Forkhead box protein L2 *  / complex / reaction
 ENSDARG00000062650 rif1 / replication timing regulatory factor 1 / Q5UIP0* / Q6PR54* / Telomere-associated protein RIF1 *  / complex
 ENSDARG00000033443 mdm2 / MDM2 oncogene, E3 ubiquitin protein ligase / P23804* / Q00987* / MDM2 proto-oncogene* / E3 ubiquitin-protein ligase Mdm2 *  / reaction / complex
 ENSDARG00000054155 pcna / Q9PTP1 / proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / complex / reaction
 ENSDARG00000043339 Q1LVP6 / abraxas2a / abraxas 2a, BRISC complex subunit / Q8BPZ8* / Q6UWZ7* / ABRAXAS1* / BRCA1 A complex subunit* / abraxas 1, BRCA1 A complex subunit*  / complex / reaction
 ENSDARG00000036791 dnmt3bb.1 / DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.1 / Q9UBC3* / DNMT3B* / Dnmt3c* / O88509* / DNA methyltransferase 3 beta* / DNA (cytosine-5)-methyltransferase 3B *  / complex / reaction
 ENSDARG00000078574 si:dkey-21c19.3 / SENP1* / Q9P0U3* / P59110* / Sentrin-specific protease 1 * / SUMO1/sentrin specific peptidase 1*  / reaction
 ENSDARG00000000729 daxx / death-domain associated protein / Q9UER7* / Mus musculus Fas death domain-associated protein (Daxx), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000037260 toporsa / topoisomerase I binding, arginine/serine-rich a / TOPORS* / Q80Z37* / Q9NS56* / E3 ubiquitin-protein ligase Topors * / TOP1 binding arginine/serine rich protein*  / reaction / complex
 ENSDARG00000068965 nrip1a / nuclear receptor interacting protein 1a / NRIP1* / Q8CBD1* / P48552* / nuclear receptor interacting protein 1* / Mus musculus nuclear receptor interacting protein 1 (Nrip1), transc...  / reaction / complex
 ENSDARG00000068417 foxl2b / forkhead box L2b / FOXL2* / P58012* / forkhead box L2*  / complex / reaction
 ENSDARG00000073837 senp2 / SUMO1/sentrin/SMT3 specific peptidase 2 / Gm7275* / Gm5407* / Gm5415* / Q91ZX6* / Q9HC62* / AF366264* / 4930444G20Rik* / cDNA sequence AF366264* / RIKEN cDNA 4930444G20 gene* / Mus ...  / reaction
 ENSDARG00000071551 xrcc6 / X-ray repair complementing defective repair in Chinese hamster cells 6 / P12956* / X-ray repair cross complementing 6*  / reaction
 ENSDARG00000024488 top2a / DNA topoisomerase II alpha / P11388* / Q01320* / DNA topoisomerase 2-alpha *  / complex / reaction
 ENSDARG00000035655 rad21b / RAD21 cohesin complex component b / RAD21* / Q61550* / O60216* / Double-strand-break repair * / RAD21 cohesin complex component*  / complex
 ENSDARG00000034195 top2b / DNA topoisomerase II beta / Q02880* / Q64511* / DNA topoisomerase 2-beta *  / complex / reaction
 ENSDARG00000013076 bmi1b / Q7T3E6 / bmi1 polycomb ring finger oncogene 1b / BMI1* / P25916* / P35226* / COMMD3-BMI1* / COMMD3-BMI1 readthrough* / Polycomb complex protein BMI-1 * / BMI1 proto-oncogene, polyco...  / complex
 ENSDARG00000040606 tfap2c / transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) / Q61312* / Q92754* / transcription factor AP-2 gamma*  / complex / reaction
 ENSDARG00000021405 chd3 / chromodomain helicase DNA binding protein 3 / Q12873*  / complex
 ENSDARG00000052654 thrab / thyroid hormone receptor alpha b / THRA* / P63058* / P10827* / thyroid hormone receptor, alpha*  / reaction / complex
 ENSDARG00000068894 nrip1b / nuclear receptor interacting protein 1b / NRIP1* / Q8CBD1* / P48552* / nuclear receptor interacting protein 1* / Mus musculus nuclear receptor interacting protein 1 (Nrip1), transc...  / reaction / complex
 ENSDARG00000102082 nr3c2 / nuclear receptor subfamily 3, group C, member 2 / P08235*  / reaction / complex
 ENSDARG00000098211 wrn / Werner syndrome / O09053* / Q14191* / Werner syndrome RecQ like helicase*  / complex / reaction
 ENSDARG00000104353 nop58 / NOP58 ribonucleoprotein homolog (yeast) / Q6DFW4* / Q9Y2X3* / Nucleolar protein 58 * / NOP58 ribonucleoprotein*  / reaction / complex
 ENSDARG00000098349 hdac4 / histone deacetylase 4 / P56524* / Q6NZM9*  / reaction / complex
 ENSDARG00000099298 xrcc5 / X-ray repair complementing defective repair in Chinese hamster cells 5 / P13010* / X-ray repair cross complementing 5*  / reaction
 ENSDARG00000112483 rnf168 / ring finger protein 168 / Q8IYW5*  / complex / reaction
 ENSDARG00000116835 park7 / Q5XJ36 / parkinson protein 7 / Q99497* / Parkinsonism associated deglycase*  / reaction / complex






 

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