ENSDARG00000018257


Danio rerio

Features
Gene ID: ENSDARG00000018257
  
Biological name :ncoa1
  
Synonyms : ncoa1 / nuclear receptor coactivator 1
  
Possible biological names infered from orthology : P70365 / Q15788
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 36682051
Gene end: 36792710
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000045947
Ensembl peptide - ENSDARP00000111627
NCBI entrez gene - 563288     See in Manteia.
RefSeq - XM_686652
swissprot - Q5RIG3
ZFIN ID - ZDB-GENE-041001-175
Ensembl - ENSDARG00000018257
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NCOA1ENSGALG00000016617Gallus gallus
 NCOA1ENSG00000084676Homo sapiens
 Ncoa1ENSMUSG00000020647Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ncoa2 / nuclear receptor coactivator 2 / Q15596* / Q61026*ENSDARG0000001792934
ncoa3 / nuclear receptor coactivator 3 / Q9Y6Q9*ENSDARG0000007740430


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR009110  Nuclear receptor coactivator, interlocking
 IPR010011  Domain of unknown function DUF1518
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013767  PAS fold
 IPR014920  Nuclear receptor coactivator, Ncoa-type, interlocking
 IPR014935  Nuclear receptor coactivator, receptor-binding domain
 IPR017426  Nuclear receptor coactivator
 IPR028819  Nuclear receptor coactivator 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IEA
 molecular_functionGO:0035257 nuclear hormone receptor binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Recycling of bile acids and salts
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Endogenous sterols
HATs acetylate histones
SUMOylation of transcription cofactors
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018698 carm1 / Q6DC04 / coactivator-associated arginine methyltransferase 1 / Q9WVG6* / Q86X55* / Histone-arginine methyltransferase CARM1 *  / reaction / complex
 ENSDARG00000010246 prmt1 / protein arginine methyltransferase 1 / Q99873* / Q9JIF0* / protein arginine N-methyltransferase 1*  / complex / reaction
 ENSDARG00000010192 pax3a / paired box 3a / PAX3* / P23760* / P24610* / paired box 3*  / reaction / complex
 ENSDARG00000004111 esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor *  / complex / reaction
 ENSDARG00000028348 pax3b / paired box 3b / PAX3* / P23760* / paired box 3*  / complex / reaction
 ENSDARG00000014994 tbp / Q7SXL3 / TATA box binding protein / P20226* / P29037*  / complex / reaction
 ENSDARG00000016526 gata3 / Q91428 / GATA binding protein 3 / P23771* / P23772* / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA.*  / reaction / complex
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000057737 rxraa / retinoid X receptor, alpha a / RXRA* / P19793* / P28700* / retinoid X receptor alpha*  / reaction / complex
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000017929 ncoa2 / nuclear receptor coactivator 2 / Q15596* / Q61026*  / complex / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / reaction / complex
 ENSDARG00000053685 gtf2a2 / general transcription factor IIA, 2 / P52657* / Q80ZM7* / general transcription factor IIA subunit 2* / Transcription initiation factor IIA subunit 2 *  / complex / reaction






 

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