ENSDARG00000010192


Danio rerio

Features
Gene ID: ENSDARG00000010192
  
Biological name :pax3a
  
Synonyms : paired box 3a / pax3a
  
Possible biological names infered from orthology : P23760 / P24610 / paired box 3 / PAX3
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 47370323
Gene end: 47431205
  
Corresponding Affymetrix probe sets: Dr.579.1.S1_at (Zebrafish Array)   NM_131277_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000022138
Ensembl peptide - ENSDARP00000037761
NCBI entrez gene - 30532     See in Manteia.
RefSeq - NM_131277
RefSeq Peptide - NP_571352
swissprot - F1R7Y4
swissprot - O57416
ZFIN ID - ZDB-GENE-980526-52
Ensembl - ENSDARG00000010192
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PAX3ENSGALG00000030944Gallus gallus
 PAX3ENSG00000135903Homo sapiens
 Pax3ENSMUSG00000004872Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pax7a / paired box 7a / PAX7* / P23759* / paired box 7*ENSDARG0000010039868
pax7b / paired box 7b / PAX7* / P47239* / P23759* / paired box 7* / Paired box protein Pax-7 *ENSDARG0000007081867
pax3b / paired box 3b / PAX3* / P23760* / paired box 3*ENSDARG0000002834865
pax6a / P26630 / paired box 6aENSDARG0000010337932
pax6b / paired box 6bENSDARG0000004593631
pax2a / Q90268 / paired box 2a / PAX2* / Q02962* / paired box 2*ENSDARG0000002814828
pax2b / paired box 2b / PAX2* / Q02962* / paired box 2*ENSDARG0000003257827
pax5 / paired box 5 / Q02548* / Q02650* / Paired box protein Pax-5 *ENSDARG0000003738326
pax8 / paired box 8 / Q06710*ENSDARG0000001587926
pax1b / paired box 1b / PAX1* / P15863* / P09084* / paired box 1* / Paired box protein Pax-1 *ENSDARG0000007381425
pax1a / paired box 1a / PAX1* / P15863* / paired box 1*ENSDARG0000000820325
pax9 / paired box 9 / P47242* / P55771* / Paired box protein Pax-9 *ENSDARG0000005382924
pax4 / paired box 4 / O43316* / P32115*ENSDARG0000002133619


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001523  Paired domain
 IPR009057  Homeobox-like domain superfamily
 IPR011991  ArsR-like helix-turn-helix domain
 IPR017970  Homeobox, conserved site
 IPR022106  Paired box protein 7, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0048066 developmental pigmentation IMP
 biological_processGO:0048484 enteric nervous system development IMP
 biological_processGO:0050936 xanthophore differentiation IMP
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
HATs acetylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000132 neural plate neural plate morphology , abnormal
Show

 ZFA:0000200 dorsal root ganglion dorsal root ganglion sensory neuron mislocalised dorsally , abnormal
Show

 ZFA:0000204 esophagus esophagus skeletal muscle cell poorly differentiated , abnormal
esophagus lacks parts or has fewer parts of type skeletal muscle cell , abnormal
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 ZFA:0000301 medial rectus medial rectus aplastic , abnormal
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 ZFA:0000457 ventral rectus ventral rectus aplastic , abnormal
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 ZFA:0000563 pectoral fin musculature pectoral fin musculature decreased size , abnormal
pectoral fin musculature disorganized , abnormal
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 ZFA:0001114 head head xanthophore decreased amount , abnormal
head pterinosome decreased amount , abnormal
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 ZFA:0001115 trunk trunk xanthophore colorless , abnormal
trunk xanthophore absent , abnormal
trunk pterinosome absent , abnormal
trunk melanocyte increased amount , abnormal
trunk melanocyte decreased size , abnormal
trunk melanocyte mislocalised , abnormal
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 ZFA:0001155 enteric nervous system enteric nervous system neuron neural crest derived absent , abnormal
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 ZFA:0001194 cranial neural crest cranial neural crest morphology , abnormal
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 ZFA:0001306 pharyngeal arch pharyngeal arch muscle aplastic , abnormal
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 ZFA:0001334 presumptive enteric nervous system presumptive enteric nervous system neuron neural crest derived decreased amount , abnormal
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 ZFA:0001463 melanophore stripe melanophore stripe melanocyte increased amount , abnormal
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 ZFA:0001651 sternohyoid sternohyoid aplastic , abnormal
sternohyoid decreased size , abnormal
sternohyoid disorganized , abnormal
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 ZFA:0009003 cranial neural crest cell cranial neural crest cell decreased amount , abnormal
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 ZFA:0009004 trunk neural crest cell trunk neural crest cell decreased amount , abnormal
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 ZFA:0009165 neural crest cell neural crest cell delaminated , abnormal
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 ZFA:0009198 xanthophore xanthophore decreased amount , abnormal
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 ZFA:0009249 melanoblast melanoblast decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018257 ncoa1 / nuclear receptor coactivator 1 / P70365* / Q15788*  / reaction / complex






 

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