ENSMUSG00000004872


Mus musculus

Features
Gene ID: ENSMUSG00000004872
  
Biological name :Pax3
  
Synonyms : P24610 / paired box 3 / Pax3
  
Possible biological names infered from orthology : P23760
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C4
Gene start: 78101267
Gene end: 78197134
  
Corresponding Affymetrix probe sets: 10355916 (MoGene1.0st)   1420389_at (Mouse Genome 430 2.0 Array)   1430335_a_at (Mouse Genome 430 2.0 Array)   1441743_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004994
Ensembl peptide - ENSMUSP00000084320
NCBI entrez gene - 18505     See in Manteia.
MGI - MGI:97487
RefSeq - NM_008781
RefSeq - NM_001159520
RefSeq Peptide - NP_001152992
RefSeq Peptide - NP_032807
swissprot - P24610
swissprot - Q8BRF1
Ensembl - ENSMUSG00000004872
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pax3aENSDARG00000010192Danio rerio
 pax3bENSDARG00000028348Danio rerio
 PAX3ENSGALG00000030944Gallus gallus
 PAX3ENSG00000135903Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pax7 / P47239 / Paired box protein Pax-7 / P23759* / paired box 7*ENSMUSG0000002873677
Pax6 / P63015 / Paired box protein Pax-6 / P26367* / paired box 6*ENSMUSG0000002716832
Pax5 / Q02650 / Paired box protein Pax-5 / Q02548* / paired box 5*ENSMUSG0000001403031
Pax8 / Q00288 / Paired box protein Pax-8 / Q06710* / paired box 8*ENSMUSG0000002697630
Pax2 / paired box 2 / Q02962*ENSMUSG0000000423130
Pax1 / P09084 / Paired box protein Pax-1 / P15863* / paired box 1*ENSMUSG0000003703428
Pax9 / P47242 / Paired box protein Pax-9 / P55771* / paired box 9*ENSMUSG0000000149727
Pax4 / P32115 / paired box 4 / O43316*ENSMUSG0000002970623


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001523  Paired domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR022106  Paired box protein 7, C-terminal
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0014807 regulation of somitogenesis IMP
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0021527 spinal cord association neuron differentiation IGI
 biological_processGO:0021915 neural tube development IGI
 biological_processGO:0035914 skeletal muscle cell differentiation NAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048066 developmental pigmentation IMP
 biological_processGO:0048663 neuron fate commitment IGI
 biological_processGO:0055007 cardiac muscle cell differentiation NAS
 biological_processGO:0060538 skeletal muscle organ development IMP
 biological_processGO:0060594 mammary gland specification IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005667 transcription factor complex TAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IGI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0071837 HMG box domain binding IEA


Pathways (from Reactome)
Pathway description
HATs acetylate histones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf8tm1Mrc/Fgf8tm2Moon,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6

 MP:0000090 absent premaxilla "missing anterior and interior portion of the maxilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000102 abnormal nasal bone morphology "malformed elongated rectangular bone that forms part of the nasal bridge" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3tm1Mrc/Pax3+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Pax3tm1(FOXO1A)Gcg/Pax3+
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * NMRI)

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Pax3tm1(FOXO1A)Gcg/Pax3+
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * NMRI)

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Whrnwi/Whrn+
Genetic Background: involves: C57BL/6J * STOCK a Tyrp1b Myo5ad Oca2p Ednrbs

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3tm3.1(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt3atm1Amc/Wnt3atm1Amc
Genetic Background: involves: 129S1/Sv

 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt3atm1Amc/Wnt3atm1Amc
Genetic Background: involves: 129S1/Sv

Allelic Composition: Pax3Sp/Pax3+
Genetic Background: C57BL-Pax3Sp

Allelic Composition: Pax3Sp-d/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-d

Allelic Composition: Pax3tm1Buck/Pax3+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pax3tm2(PAX3/FOXO1A)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pax3Sp-7H/Pax3+
Genetic Background: involves: C3H/HeH * C57BL/6

Allelic Composition: Pax3Sp-4H/Pax3+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Pax3tm5Buck/Pax3+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pax3Sp-J/Pax3+
Genetic Background: C57BL/6J

Allelic Composition: Pax3Sp-2J/Pax3+
Genetic Background: C3H/HeJ-Pax3Sp-2J

Allelic Composition: Pax3Sp-3J/Pax3+
Genetic Background: involves: C57BL/6J

Allelic Composition: Pax3tm1.1Sjc/Pax3tm1.2Sjc
Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Pax3Sp-2H/Pax3+
Genetic Background: involves: 101 * C3H/He * CBA/Ca

Allelic Composition: Pax3tm2Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax3Sp-10J/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-10J/GrsrJ

Allelic Composition: Pax3tm6.1(Pax8)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3tm6(Pax8)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pax3Sp-1Xzg/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-1Xzg

Allelic Composition: Pax3Sp-1Wli/Pax3+
Genetic Background: involves: C57BL/6J * CBA/CaJ

Allelic Composition: KitWps/Kit+,Pax3Sp-1Wli/Pax3+
Genetic Background: involves: C57BL/6J * CBA/CaJ

Allelic Composition: Pax3Sp-2J/Pax3+
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Pax3Sp/Pax3+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Pax3Rwa/Pax3+
Genetic Background: B6N.Cg-Pax3Rwa

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Fgf8tm1Mrc/Fgf8tm2Moon,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6

 MP:0000457 maxilla hypoplasia "arrested growth or atrophy of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Pax3tm1Mrc/Pax3+,Pax7tm1(cre)Mrc/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
Genetic Background: Not Specified

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: C57BL-Pax3Sp

 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Whrnwi/Whrn+
Genetic Background: involves: C57BL/6J * STOCK a Tyrp1b Myo5ad Oca2p Ednrbs

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Whrnwi/Whrn+
Genetic Background: involves: C57BL/6J * STOCK a Tyrp1b Myo5ad Oca2p Ednrbs

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: involves: C57BL

Allelic Composition: Pax3tm1Buck/Pax3tm1Buck
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3tm1Buck/Pax3Sp
Genetic Background: involves: 129P2/OlaHsd * C57BL

Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3tm3.1(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pax3tm5.1Buck/Pax3+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

 MP:0000733 abnormal muscle development "anomalous differentiation of muscle tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ednratm2Ywa/Ednratm2Ywa
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL * C57BL/6

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3tm3.1(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pax3tm6.1(Pax8)Buck/Pax3tm6.2Buck
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

Allelic Composition: Pax3tm6.1(Pax8)Buck/Pax3tm6.1(Pax8)Buck
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3tm6.1(Pax8)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3tm6(Pax8)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Fat1tm1Fhel/Fat1tm1Fhel,Pax3tm1(cre)Joe/Pax3+,Tg(Myl1-lacZ)1Ibdml/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL

 MP:0000734 muscle hypoplasia "underdevelopment or atrophy of muscle" [J:15108]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Pax7tm1(cre)Mrc/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000737 abnormal myotome development "malformation of or absence of the part of the somite that develops into the musculature" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29279]
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Allelic Composition: Pax3tm1Buck/Pax3tm1Buck
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pax3tm1Buck/Pax3tm1Buck,Pax7tm2Pgr/Pax7tm2Pgr
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas)

Allelic Composition: Pax3tm6.1(Pax8)Buck/Pax3tm6.1(Pax8)Buck
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3tm6.1(Pax8)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3tm6(Pax8)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3tm1(FOXO1A)Gcg/Pax3+
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * NMRI)

Allelic Composition: Fat1tm1Fhel/Fat1tm1Fhel,Pax3tm1(cre)Joe/Pax3+,Tg(Myl1-lacZ)1Ibdml/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL

 MP:0000761 thin diaphragm muscle "reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
Genetic Background: Not Specified

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0000784 forebrain hypoplasia "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: a/a,Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

 MP:0000822 abnormal brain ventricle morphology "malformed or absent fluid filled cavities of the cerebrum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: C57BL-Pax3Sp

 MP:0000823 abnormal lateral ventricle morphology "malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: a/a,Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

 MP:0000841 abnormal hindbrain morphology "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Pax3Sp-7H/Pax3+
Genetic Background: involves: C3H/HeH * C57BL/6

 MP:0000898 midbrain hyperplasia "increased cell number associated with the middle of the three cerebral vesicles of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: 101 * C3H/He * CBA/Ca

Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: DBA/2

Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: NZW

Allelic Composition: Pax3Sp-d/Pax3Sp-d
Genetic Background: C57BL/6J-Pax3Sp-d

Allelic Composition: Pax3tm1Buck/Pax3tm1Buck
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pax3tm1Buck/Pax3Sp
Genetic Background: involves: 129P2/OlaHsd * C57BL

Allelic Composition: Pax3tm1Mrc/Pax3+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Lbx2tm1Fchn/Lbx2tm1Fchn,Pax3Sp/Pax3Sp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
Genetic Background: Not Specified

Allelic Composition: Pax3tm1(FOXO1A)Gcg/Pax3+
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * NMRI)

Allelic Composition: Pax3tm2Joe/Pax3tm2Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax3tm6.2Buck/Pax3tm6.2Buck
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Pax3tm6.1(Pax8)Buck/Pax3tm6.1(Pax8)Buck
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3Sp-1Xzg/Pax3Sp-1Xzg
Genetic Background: C57BL/6J-Pax3Sp-1Xzg

Allelic Composition: Pax3Sp-1Wli/Pax3Sp-1Wli
Genetic Background: involves: C57BL/6J * CBA/CaJ

Allelic Composition: a/a,Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

 MP:0000919 cranioschisis "incomplete closure of the skull, usually congenital " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: a/a,Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: 101 * C3H/He * CBA/Ca

Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: DBA/2

Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: NZW

Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: C57BL-Pax3Sp

Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: involves: C57BL

Allelic Composition: Pax3tm1Buck/Pax3Sp
Genetic Background: involves: 129P2/OlaHsd * C57BL

Allelic Composition: Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

Allelic Composition: Fignfi/Fignfi,Pax3Sp/Pax3Sp
Genetic Background: BR.Cg-Pax3Sp Fignfi

Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: involves: 129S2/SvPas * C57BL * C57BL/6J * FVB

Allelic Composition: Pax3Sp/Pax3Sp,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL * C57BL/6J * FVB

Allelic Composition: Lbx2tm1Fchn/Lbx2tm1Fchn,Pax3Sp/Pax3Sp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
Genetic Background: Not Specified

Allelic Composition: Lbx1tm1Thbr/Lbx1tm1Thbr,Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * 129S4/SvJae * C3H/HeH * C57BL/6

Allelic Composition: Pax3tm6(Pax8)Buck/Pax3tm6(Pax8)Buck
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pax3Sp-1Xzg/Pax3Sp-1Xzg
Genetic Background: C57BL/6J-Pax3Sp-1Xzg

Allelic Composition: Pax3Rwa/Pax3Rwa
Genetic Background: B6N.Cg-Pax3Rwa

 MP:0000936 small telencephalic vesicles "reduced size of the paired diverticula of the telencephalon, from which the forebrain develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: C57BL-Pax3Sp

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Whrnwi/Whrn+
Genetic Background: involves: C57BL/6J * STOCK a Tyrp1b Myo5ad Oca2p Ednrbs

 MP:0000959 abnormal somatic sensory system morphology 
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Allelic Composition: Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sortm1Fia,Hprttm1(CMV-cre)Brd/Hprt+,Nf1tm1Fcr/Nf1tm1Fcr
Genetic Background: involves: 129S/SvEv * 129S/SvEvBrd

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
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Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: C57BL-Pax3Sp

Allelic Composition: Pax3Sp-d/Pax3Sp-d
Genetic Background: C57BL/6J-Pax3Sp-d

Allelic Composition: Pax3tm1Buck/Pax3tm1Buck
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

Allelic Composition: Lbx2tm1Fchn/Lbx2tm1Fchn,Pax3Sp/Pax3Sp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pax3tm6.1(Pax8)Buck/Pax3tm6.1(Pax8)Buck
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

 MP:0000962 disorganized dorsal root ganglia "loss of segmentation pattern of DRGs; loss of regular spacing " [J:62022, J:62023]
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Allelic Composition: Pax3Sp-d/Pax3Sp-d
Genetic Background: C57BL/6J-Pax3Sp-d

 MP:0000964 small dorsal root ganglia "reduced size of the dorsal root ganglia" [J:17123]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0001045 abnormal enteric ganglia morphology "any strucutural anomaly or deformity of the groups of nerve cell bodies associated with the enteric neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Pax3Sp/Pax3+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Lbx2tm1Fchn/Lbx2tm1Fchn,Pax3Sp/Pax3Sp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001189 absent skin pigmentation "lack of pigmentation of the skin" [J:53370]
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Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: C57BL-Pax3Sp

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Pax7tm1(cre)Mrc/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Pax3Sp-6H/Pax3Sp-6H
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Arl13bhnn/Arl13btm1Tc,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001341 absent eyelids "missing skin folds covering the front of the eyeball when closed" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001404 no spontaneous movement "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Pax3tm1(FOXO1A)Gcg/Pax3+
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * NMRI)

Allelic Composition: Pax3tm2Joe/Pax3tm2Joe,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax3tm1Buck/Pax3tm1Buck
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3tm1Buck/Pax3tm1Buck
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pax3tm6.1(Pax8)Buck/Pax3tm6.1(Pax8)Buck
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
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Allelic Composition: Bloc1s4cno/Bloc1s4cno
Genetic Background: involves: C3H/HeJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Pax3Rwa/Pax3Rwa
Genetic Background: B6N.Cg-Pax3Rwa

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Pax7tm1(cre)Mrc/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Sh3bp2tm1Geha/Sh3bp2tm1Geha
Genetic Background: Not Specified

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pax3tm2Joe/Pax3tm2Joe,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Pax3tm1(FOXO1A)Gcg/Pax3+
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * NMRI)

Allelic Composition: Arl13bhnn/Arl13btm1Tc,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Nr2c2tm1Bbm/Nr2c2tm1Bbm,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002036 rhabdomyosarcoma "malignant tumor derived from skeletal (striated) muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: C3ar1tm1Raw/C3ar1tm1Raw,Cpn1tm1Raw/Cpn1tm1Raw
Genetic Background: B6.129-C3ar1tm1Raw Cpn1tm1Raw

Allelic Composition: Myf6tm1(cre)Mrc/Myf6+,Pax3tm1Mrc/Pax3tm1Mrc,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Myf6tm1(cre)Mrc/Myf6+,Pax3tm1Mrc/Pax3tm1Mrc,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Myf6tm1(cre)Mrc/Myf6+,Pax3tm1Mrc/Pax3tm1Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp6Gw/Lrp6Gw
Genetic Background: involves: 101/H * BALB/cOlaHsd * C3H/HeH

Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Pax3Sp/Pax3+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Tg(Tagln-cre)1Her/?
Genetic Background: involves: 129 * C57BL/6

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax3Sp-1Xzg/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-1Xzg

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aldh1a2tm1Dll/Aldh1a2tm1Ipc
Genetic Background: involves: CD-1

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: C57BL-Pax3Sp

Allelic Composition: Pax3Sp-d/Pax3Sp-d
Genetic Background: C57BL/6J-Pax3Sp-d

Allelic Composition: Pax3tm1Buck/Pax3tm1Buck
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1tm4Wbm,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
Genetic Background: Not Specified

Allelic Composition: Pax3tm1(FOXO1A)Gcg/Pax3+
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * NMRI)

Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

Allelic Composition: Pax3tm6.1(Pax8)Buck/Pax3tm6.2Buck
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

Allelic Composition: Pax3tm6.1(Pax8)Buck/Pax3tm6.1(Pax8)Buck
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Itm2atm1.1Buck/Y,Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
Genetic Background: involves: C57BL/6

Allelic Composition: Itm2atm1.2Buck/Y,Pax3tm4Buck/Pax3tm4Buck
Genetic Background: involves: C57BL/6

Allelic Composition: Pax3Sp-1Wli/Pax3Sp-1Wli
Genetic Background: involves: C57BL/6J * CBA/CaJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cebpbtm1Pfj/Cebpbtm1Pfj
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Pax3tm1.1Sjc/Pax3+
Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Pax3tm1(cre)Joe/Pax3tm2Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax3tm2.1Joe/Pax3tm2.1Joe
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * BALB/cJ) or (involves: 129S1/Sv * 129X1/SvJ * FVB/N)

Allelic Composition: Itm2atm1.1Buck/Y,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: C57BL/6

 MP:0002233 abnormal nose morphology "any structural anomaly of the organ that is specialized for smell and is part of the respiratory system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Pax7tm1(cre)Mrc/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax3tm1(FOXO1A)Gcg/Pax3+
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * NMRI)

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Pax3Sp-d/Pax3Sp-d,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * SJL/J

 MP:0002280 abnormal intercostal muscle morphology "anomaly in the respiratory muscles that arise from the lower border of one rib and insert into the upper border of the adjoining rib " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

 MP:0002367 abnormal thymus lobule morphology "anomalous structure or development of the basic structural unit of the thymus" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax3tm1(FOXO1A)Gcg/Pax3+
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * NMRI)

 MP:0002428 abnormal semicircular canal "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: involves: C57BL

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bcrtm1(BCR/ABL)Tsr/Bcr+,Runx1tm3Dow/Runx1+,Tg(Vav1-cre)#Cgp/0
Genetic Background: involves: C57BL/6

Allelic Composition: Egln1tm2.1Fsl/Egln1+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

 MP:0002621 delayed neural tube closure "delayed fusion of the neuroepithelial layer in early development" [J:79790, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Pax3Sp-7H/Pax3+
Genetic Background: involves: C3H/HeH * C57BL/6

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: 101 * C3H/He * CBA/Ca

Allelic Composition: Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

Allelic Composition: Pax3tm2Joe/Pax3tm2Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002672 abnormal branchial arch artery morphology "malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

 MP:0002734 abnormal mechanical nociception "abnormal capability to sense pain elicited by mechanical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nr2c2tm1Bbm/Nr2c2tm1Bbm,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: 101 * C3H/He * CBA/Ca

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: 101 * C3H/He * CBA/Ca

 MP:0002820 abnormal premaxilla morphology "malformation or absence of the anterior and inner portion of the maxilla" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:76662]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Pax7tm1(cre)Mrc/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002823 abnormal rib development "anomalous formation of the bones forming the bony wall of the chest" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84754]
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Allelic Composition: Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

 MP:0002872 polycythemia "an excess of circulating red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Egln1tm2.1Fsl/Egln1+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002938 white spotting "the appearance of patches of white fur" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax3Sp/Pax3+
Genetic Background: C57BL-Pax3Sp

Allelic Composition: Pax3Sp-5H/Pax3Sp-5H
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Pax3Sp-6H/Pax3Sp-6H
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Pax3Sp-10J/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-10J/GrsrJ

Allelic Composition: Pax3Sp-1Xzg/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-1Xzg

Allelic Composition: Pax3Sp-1Wli/Pax3+
Genetic Background: involves: C57BL/6J * CBA/CaJ

Allelic Composition: KitWps/Kit+,Pax3Sp-1Wli/Pax3+
Genetic Background: involves: C57BL/6J * CBA/CaJ

 MP:0002939 head spot "the appearance of a round area of white fur on the head" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax3Sp-2J/Pax3+
Genetic Background: C3H/HeJ-Pax3Sp-2J

Allelic Composition: Pax3tm1.1Sjc/Pax3tm1.2Sjc
Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6

 MP:0002940 variable body spotting "the appearance of patches of white fur at random on the coat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax3Sp-4H/Pax3+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Pax3M1Btlr/Pax3M1Btlr
Genetic Background: C57BL/6J-Pax3M1Btlr

Allelic Composition: Pax3m2Btlr/Pax3m2Btlr
Genetic Background: C57BL/6J-Pax3M2Btlr

 MP:0002950 abnormal neural crest cell migration "defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Pax3tm1Buck/Pax3tm1Buck
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pax3tm1Buck/Pax3Sp
Genetic Background: involves: 129P2/OlaHsd * C57BL

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pax3Sp-7H/Pax3Sp-7H
Genetic Background: involves: C3H/HeH * C57BL/6

Allelic Composition: Pax3tm6.1(Pax8)Buck/Pax3tm6.1(Pax8)Buck
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3tm6(Pax8)Buck/Pax3tm6(Pax8)Buck
Genetic Background: involves: 129S2/SvPas

 MP:0002951 small thyroid gland "reduced size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

 MP:0003007 ectopic thymus "ectopic location of the thymus primordium, which normally resides in the superior mediastinum and lower part of the neck" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:76015]
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Allelic Composition: Pax3tm1(FOXO1A)Gcg/Pax3+
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * NMRI)

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Pax3Sp-d/Pax3Sp-d
Genetic Background: C57BL/6J-Pax3Sp-d

Allelic Composition: Pax3Sp-10J/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-10J/GrsrJ

Allelic Composition: Pax3Sp-1Xzg/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-1Xzg

Allelic Composition: Pax3Rwa/Pax3+
Genetic Background: B6N.Cg-Pax3Rwa

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: 101 * C3H/He * CBA/Ca

Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: DBA/2

Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: NZW

Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: C57BL-Pax3Sp

Allelic Composition: Pax3Sp-d/Pax3Sp-d
Genetic Background: C57BL/6J-Pax3Sp-d

Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: involves: C57BL

Allelic Composition: Pax3tm1Buck/Pax3tm1Buck
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pax3tm5.1Buck/Pax3+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3Sp/Pax3+
Genetic Background: involves: C3HeB * C57BL * C57BL/6J * SWV

Allelic Composition: Pax3tm1(FOXO1A)Gcg/Pax3+
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * NMRI)

Allelic Composition: Pax3tm2Joe/Pax3tm2Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax3tm2Joe/Pax3tm2Joe,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Pax3tm6.1(Pax8)Buck/Pax3tm6.1(Pax8)Buck
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3Sp-1Xzg/Pax3Sp-1Xzg
Genetic Background: C57BL/6J-Pax3Sp-1Xzg

Allelic Composition: Pax3Sp-1Wli/Pax3Sp-1Wli
Genetic Background: involves: C57BL/6J * CBA/CaJ

Allelic Composition: Pax3Rwa/Pax3+
Genetic Background: B6N.Cg-Pax3Rwa

 MP:0003090 abnormal muscle progenitor cell migration "defects in the movement of cells that will develop into muscle cells out of the somites and/or to the appropriate location in the body" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: involves: C57BL

Allelic Composition: Pax3tm1Buck/Pax3tm1Buck
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3tm3.1(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pax3tm6.1(Pax8)Buck/Pax3tm6.1(Pax8)Buck
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

 MP:0003148 reduced cochlear coiling "a reduction in cochlear coiling or number of turns; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns" [J:56294, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: involves: C57BL

 MP:0003246 loss of GABA neurons "loss of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

 MP:0003247 abnormal glutaminergic neuron "malformation or absence of the neurons that utilize glutamate as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

 MP:0003248 loss of glutamate neurons "loss of the neurons that utilize glutamate as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0003359 hypaxial muscle hypoplasia "reduced cell number in the muscles of the limbs" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pax3tm2Joe/Pax3tm2Joe,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0003451 absent olfactory bulb "absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: a/a,Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

 MP:0003760 short palate "abnormally decreased length to the roof of the oral cavity" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003833 decreased number of satellite cells "less than the normal number of unfused cells in muscle that play a role in muscle regeneration" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Pax7tm1(cre)Mrc/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

 MP:0003864 abnormal midbrain development "anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: C57BL-Pax3Sp

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dkk1tm1.1Svo/Dkk1tm1.2Svo,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003939 abnormal myotome morphology "structural anomaly in the mesoderm that is derived from the somite that is fated to beome the musculature" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dkk1tm1.1Svo/Dkk1tm1.2Svo,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

 MP:0004136 abnormal tongue muscle morphology "anomalous structure or development of the muscular portion of the tongue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pax3tm1(FOXO1A)Gcg/Pax3+
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * NMRI)

 MP:0004160 retroesophageal right subclavian artery "the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

 MP:0004206 abnormal dermomyotome development "any structural anomaly of the portion of the embryonic somite that remains after migration of the sclerotomic tissue" [J:50279, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: involves: C57BL

Allelic Composition: Pax3tm1Buck/Pax3tm1Buck
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3tm1Buck/Pax3Sp
Genetic Background: involves: 129P2/OlaHsd * C57BL

Allelic Composition: Pax3tm5.1Buck/Pax3+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3tm6.1(Pax8)Buck/Pax3tm6.1(Pax8)Buck
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: 101 * C3H/He * CBA/Ca

 MP:0004248 abnormal epaxial muscle morphology "any structural anomaly of the muscles derived from the medial myotome; includes the intrinsic back muscles" [PMID:1591996]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

 MP:0004289 abnormal bony labyrinth "any structural abnormality in the series of cavities (cochlea, vestibule, and semicircular canals) contained within the otic capsule of the petrous portion of the temporal bone; the bony labyrinth is filled with perilymph, in which the delicate, endolymph-filled membranous labyrinth is suspended" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: involves: C57BL

 MP:0004376 absent frontal bone "absence of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0004383 absent interparietal bone "absence of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0004419 absent parietal bone "absence of the curved bone forming part of the vault of the cranium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0004452 abnormal pterygoid process morphology "any structural anomaly of the process projecting downward from either side of the sphenoid bone, in vertebrates divided into two plates, an inner and an outer (sometimes called the lateral and medial); the posterior nares pass through the space, called the pterygoid fossa, between the processes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004454 absent pterygoid process "absence of the process projecting downward from either side of the sphenoid bone, in vertebrates divided into two plates, an inner and an outer (sometimes called the lateral and medial); the posterior nares pass through the space, called the pterygoid fossa, between the processes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004458 absent alisphenoid bone "absence of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004460 alisphenoid bone hypoplasia "underdevelopment or reduced size in either of the broad curved wing like expanses on each side of the sphenoid bone in adults, usually due to reduced cell number; this bone may exist independently in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004477 turbinate hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, in the small curved bones that extends horizontally along the lateral wall of the nasal passage" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Pax7tm1(cre)Mrc/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0004760 increased mitotic index "increased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]
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Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: C57BL-Pax3Sp

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Pax7tm1(cre)Mrc/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004838 abnormal neural fold elevation formation "any anomaly in the process by which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: 101 * C3H/He * CBA/Ca

 MP:0004846 absent skeletal muscle "absence of any of the striated muscle fibers connected at either or both extremities with the bony framework of the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pax3tm6.1(Pax8)Buck/Pax3tm6.1(Pax8)Buck
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3tm6(Pax8)Buck/Pax3tm6(Pax8)Buck
Genetic Background: involves: 129S2/SvPas

 MP:0004914 absent ultimobranchial body "absence of the sac-like structure emanating from the caudal-most branchial pouch of the embryo which develops into the lateral portion of the thyroid" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0005171 lack of coat pigmentation "fur is devoid of coloration and appears white " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
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Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: C57BL-Pax3Sp

 MP:0005314 absent thyroid gland " missing endocrine gland that is normally located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30559]
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Allelic Composition: Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

 MP:0005408 hypopigmentation "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Pax3Sp-1Xzg/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-1Xzg

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: 101 * C3H/He * CBA/Ca

 MP:0006011 abnormal endolymphatic duct morphology "any structural alteration in the small membranous canal, connecting with both saccule and utricle of the membranous labyrinth, passing through the aqueduct of vestibule, and terminating in the endolymphatic sac." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: involves: C57BL

 MP:0006020 reduced size of tympanic ring "smaller than average tympanic ring" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006030 abnormal otic vesicle formation "anomalous formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
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Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: involves: C57BL

 MP:0006062 abnormal vena cava morphology "structural malformation of either of the two largest veins in the body " [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Pax3tm1(FOXO1A)Gcg/Pax3+
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * NMRI)

 MP:0006089 abnormal saccule morphology "malformation in the smaller of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]
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Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: involves: C57BL

 MP:0006090 abnormal utricle morphology "malformation in the larger of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]
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Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: involves: C57BL

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pax3tm2Joe/Pax3tm2Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pax3tm1(FOXO1A)Gcg/Pax3+
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * NMRI)

 MP:0006284 absent hypaxial muscle "absence of the muscles derived from the lateral myotome and lateral portion of the dermomyotome; these include the thoracic intercostal and abdominal muscles, limb muscles and superficial back muscles, as well as the diaphragm and the tip of the tongue" [J:86619, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3tm2Joe/Pax3tm2Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006355 abnormal sixth branchial arch artery morphology "any structural anomaly of the vessels formed within the sixth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

 MP:0008065 short endolymphatic duct "length reduction or truncation of the small membranous canal which connects with both saccule and utricle of the membranous labyrinth, passes through the aqueduct of vestibule, and terminates in the endolymphatic sac" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: involves: C57BL

 MP:0008237 abnormal ventral coat pigmentation "irregular or unusual pigmentation of ventrum hair in relation to control animals" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3Rwa/Pax3+
Genetic Background: B6N.Cg-Pax3Rwa

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008301 adrenal medulla hyperplasia "overdevelopment or increased size of the inner portion of the adrenal gland that consists mainly of chromaffin cells, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Par,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008460 absent dorsal root ganglion "absence of the groups of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column" [MESH:A08.340.390.340, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3tm1Buck/Pax3Sp
Genetic Background: involves: 129P2/OlaHsd * C57BL

Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pax3tm6(Pax8)Buck/Pax3tm6(Pax8)Buck
Genetic Background: involves: 129S2/SvPas

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr2c2tm1Bbm/Nr2c2tm1Bbm,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3Rwa/Pax3Rwa
Genetic Background: B6N.Cg-Pax3Rwa

 MP:0008934 absent choroid plexus "absence of the fringe of the tela choroidea of the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: a/a,Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Nr2c2tm1Bbm/Nr2c2tm1Bbm,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0009245 caudal rachischisis "congential fissure of the vertebral column at the caudal end of the body" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3Sp-d/Pax3Sp-d
Genetic Background: C57BL/6J-Pax3Sp-d

 MP:0009264 failure of eyelid fusion "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Pax7tm1(cre)Mrc/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009407 increased skeletal muscle fiber density "increase in the number of skeletal muscle fibers in a given cross-sectional area of a skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Pax7tm1(cre)Mrc/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009651 abnormal eyelid development "aberrant formation of the skin folds covering the front of the eyeball" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009655 abnormal secondary palate development "any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766]
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3tm2Joe/Pax3tm2Joe,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0009820 abnormal liver vasculature morphology "any structural anomaly of the blood vessel network of the bile-secreting exocrine gland" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Egln1tm2.1Fsl/Egln1tm2.1Fsl,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
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Allelic Composition: Gt(ROSA)26Sortm2(Pax3)Joe/Gt(ROSA)26Sortm2(Pax3)Joe,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009933 abnormal tail hair pigmentation "an anomaly in the expected coloration of hair on the dorsal and/or ventral surface of the tail" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Pax3Sp/Pax3+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Pax3Rwa/Pax3+
Genetic Background: B6N.Cg-Pax3Rwa

 MP:0009934 abnormal hind foot hair pigmentation "an anomaly in the expected color gradient of hair covering the metatarsals and phalanges often differentially expressed in females and males" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3Rwa/Pax3+
Genetic Background: B6N.Cg-Pax3Rwa

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

 MP:0010016 variable depigmentation "absence or loss of normal pigment in the skin in various and irregular patterns" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3tm3(Pax7)Buck/Pax3tm3(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

 MP:0010056 ectopic skeletal muscle "skeletal muscle is located in a position not normally occupied by this tissue type" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fat1tm1Fhel/Fat1tm1Fhel,Pax3tm1(cre)Joe/Pax3+,Tg(Myl1-lacZ)1Ibdml/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL

 MP:0010073 decreased pruritus "absence or decreased intensity of an uncomfortable sensation resulting from irritation of the skin or mucous membranes that evokes the desire or reflex to rub or scratch" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nr2c2tm1Bbm/Nr2c2tm1Bbm,Pax3tm1(cre)Joe/Pax3+
Genetic Background: Not Specified

 MP:0010231 transverse fur striping "presence of stripes of pigmented hair, usually black, of variable degree and location in the coat" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3Rwa/Pax3+
Genetic Background: B6N.Cg-Pax3Rwa

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: 101 * C3H/He * CBA/Ca

 MP:0010420 muscular ventricular septal defect "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]
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Allelic Composition: Pax3tm1(FOXO1A)Gcg/Pax3+
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * NMRI)

 MP:0010457 pulmonary artery stenosis "constriction or narrowing of the pulmonary artery" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

 MP:0010459 supravalvar pulmonary trunk stenosis "diffuse constriction or narrowing of the pulmonary trunk distal to the pulmonary valve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

 MP:0010463 aorta stenosis "diffuse constriction or narrowing of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

 MP:0010572 persistent right dorsal aorta "persistence of the right dorsal aorta after development; the right dorsal aorta normally regresses but when it persists, a double aortic arch develops; if the left dorsal aorta also regresses, a right aortic arch forms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

 MP:0010589 common truncal valve "a single outflow tract valve that opens into the truncus arteriosus that is frequently present in cases of truncus arteriosus septation defects" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

 MP:0010628 patent tricuspid valve "the tricuspid valve remains open during the cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3tm1(FOXO1A)Gcg/Pax3+
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * NMRI)

 MP:0010649 dilated pulmonary trunk "the luminal space of the pulmonary trunk is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3tm1(FOXO1A)Gcg/Pax3+
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * NMRI)

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3tm1(FOXO1A)Gcg/Pax3+
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * NMRI)

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
Genetic Background: Not Specified

Allelic Composition: Arl13bhnn/Arl13btm1Tc,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Notch2tm3Grid/Notch2tm3.1Grid,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129 * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1Par,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax3tm1(cre)Joe/Pax3+,Rbpjtm1Hon/Rbpjtm1Hon
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pax3tm2Joe/Pax3tm2Joe,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Pax3tm1(FOXO1A)Gcg/Pax3+
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * NMRI)

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Pax3Sp-d/Pax3Sp-d
Genetic Background: C57BL/6J-Pax3Sp-d

Allelic Composition: Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3tm3.1(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pax3tm5.1Buck/Pax3+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: BR.B-Pax3Sp

Allelic Composition: Dkk1tm1.1Svo/Dkk1tm1.2Svo,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Arl13bhnn/Arl13btm1Tc,Pax3tm1(cre)Joe/Pax3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Prrx1tm1Tex/Prrx1tm1Tex,Prrx2tm1Hubr/Prrx2tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

Allelic Composition: Pax3tm1Buck/Pax3tm1Buck
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pax3tm1Buck/Pax3Sp
Genetic Background: involves: 129P2/OlaHsd * C57BL

Allelic Composition: Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL * C57BL/6

Allelic Composition: Pax3tm1Buck/Pax3tm1Buck,Pax7tm2Pgr/Pax7tm2Pgr
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ) or (involves: 129P2/OlaHsd * 129S2/SvPas)

Allelic Composition: Fignfi/Fignfi,Pax3Sp/Pax3Sp
Genetic Background: BR.Cg-Pax3Sp Fignfi

Allelic Composition: Pax3tm2Joe/Pax3tm2Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax3Sp-10J/Pax3Sp-10J
Genetic Background: C57BL/6J-Pax3Sp-10J/GrsrJ

Allelic Composition: Pax3Sp-1Wli/Pax3Sp-1Wli
Genetic Background: involves: C57BL/6J * CBA/CaJ

Allelic Composition: Pax3Sp-2J/Pax3Sp-2J
Genetic Background: either: C3H/HeJ-Pax3Sp-2J or (involves: C3H/HeJ * C57BL/6J)

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Bloc1s4cno/Bloc1s4cno
Genetic Background: involves: C3H/HeJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: involves: C57BL

Allelic Composition: Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc,Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc,Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pax3tm1.2Sjc/Pax3tm1.2Sjc
Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Pax3Sp-1Xzg/Pax3Sp-1Xzg
Genetic Background: C57BL/6J-Pax3Sp-1Xzg

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: C57BL-Pax3Sp

Allelic Composition: Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

Allelic Composition: Pax3tm6.1(Pax8)Buck/Pax3tm6.1(Pax8)Buck
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Pax3Sp-4H/Pax3+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Pax3Sp-5H/Pax3Sp-5H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Pax3Sp-1Wli/Pax3Sp-1Wli
Genetic Background: involves: C57BL/6J * CBA/CaJ

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Pax3Sp-2H/Pax3Sp-2H
Genetic Background: involves: 101 * C3H/He * CBA/Ca

 MP:0011277 decreased tail pigmentation "visually detectable dilution of pigment present on the tail surface" [MGI:csmith]
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Allelic Composition: Pax3Sp-1Xzg/Pax3+
Genetic Background: C57BL/6J-Pax3Sp-1Xzg

 MP:0012169 optic placode degeneration "a retrogressive impairment of function or destruction of the paired thickenings of surface ectoderm that normally become invaginated to form the embryonic lens vesicles" [MGI:anna]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0012251 abnormal diaphragm development "malformation or incomplete differentiation of the thin musculomembranous barrier separating the abdominal and thoracic cavities and functioning in respiration" [MGI:anna]
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Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3tm3.1(Pax7)Buck
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pax3tm1(cre)Joe/Pax3tm1(cre)Joe
Genetic Background: Not Specified

Allelic Composition: Pax3tm1(FOXO1A)Gcg/Pax3+
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * NMRI)

 MP:0012547 spina bifida cystica "spinal bifida in which a hernial cyst containing meninges (meningocele), spinal cord (myelocele), or both (myelomeningocele) protrudes through a congenital cleft in the vertebral column; the protruding sac is encased in a layer of skin or a fine membrane that readily ruptures, causing leakage of cerebrospinal fluid and an increased risk of meningeal infection" [MGI:anna]
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Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: BR.B-Pax3Sp

 MP:0012701 increased embryonic neuroepithelium apoptosis "increase in the number of cells of the embryonic neuroepithelium undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: involves: 129S2/SvPas * C57BL * C57BL/6J * FVB

 MP:0012728 abnormal somite border morphology "any structural anomaly of the anatomical surface separating somites; somite formation requires the physical separation of somitic tissue from the initially continuous presomitic mesoderm (PSM), coalescence of cells in the forming somite, and the establishment of a stable border between the somite and the PSM; when a somite forms in the anterior end of the PSM, an intersomitic boundary (also called a fissure, gap, or cleft) emerges, and it is rapidly followed by a mesenchymal-to-epithelial transition of cells that face a forming gap" [MGI:anna]
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Allelic Composition: Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

Allelic Composition: Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL * C57BL/6

 MP:0012729 abnormal common carotid artery morphology "any structural anomaly of the left or right common carotid arteries which extend headward on each side of the anterior neck and deliver oxygenated nutrient filled blood from the heart to the head, neck and brain; the left originates in the arch of the aorta over the heart; the right originates in the brachiocephalic trunk, the largest branch from the arch of the aorta; each common carotid artery divides into an external and an internal carotid artery" [MGI:anna]
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Allelic Composition: Pax3Sp-1H/Pax3Sp-1H
Genetic Background: involves: 101/H * C3H/HeH * C57BL/6

 MP:0013720 abnormal mammary line morphology "any structural anomaly of either of the presumptive bilateral epidermal ridges (milk lines) formed at the onset of mammogenesis and running in an anteroposterior direction ventrally between fore- and hindlimbs, one line along each flank of the embryo; in mouse, mammary gland development begins shortly after mid-gestation (about E10.5); epidermal cells within the milk line become columnar and multilayered, defining a ridge that protrudes above and below the plane of the single-layered primitive epidermis or periderm; by E11.5, five pairs of lens-shaped placodes form along the mammary line at the site of each future nipple" [PMID:12558599, PMID:16524451]
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Allelic Composition: Pax3tm1Buck/Pax3tm1Buck
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013721 abnormal mammary placode morphology "any structural anomaly of the transient lens-shaped thickening of surface ectoderm that will give rise to the mammary bud proper; in mouse, five pairs of symmetrically positioned mammary placodes (three thoracic and two inguinal) form at reproducible locations along the mammary line at E11.5; the individual pairs develop asynchronously and in a distinct order; pair 3 is first, followed by pair 4, then by pairs 1 and 5 (which develop together), and finally by pair 2; the orientation of placodal cells is not uniform, suggesting that placodes are formed by migration of cells from the mammary line; between E11.5 and E12.5, each mammary placode expands and invaginates into the underlying mesenchyme to form an early bulb-shaped mammary bud " [PMID:16168142, PMID:20484386]
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Allelic Composition: Pax3tm1Buck/Pax3tm1Buck
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0014134 abnormal embryo morphology "any structural anomaly of an embryo " [MGI:csmith]
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Allelic Composition: Pax3Rwa/Pax3Rwa
Genetic Background: B6N.Cg-Pax3Rwa

 MP:0030056 lacrimal bone hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the thin plate that forms part of the medial wall of the orbit behind the frontal process of the maxilla" [MGI:anna]
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Allelic Composition: Pax3tm1Mrc/Pax3+,Pax7tm1(cre)Mrc/Pax7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030535 abnormal hypoglossal cord morphology "any structural anomaly of the condensed mesenchymal band formed as migratory myoblasts arising from the myotomes of the occipital somites coalesce beside somite four and extend ventrally as an elongated column; the hypoglossal cord eventually becomes located ventral to the caudal region of the pharynx; most of the myoblasts of the hypoglossal cord remain ventral and shift cranially to form the intrinsic and extrinsic tongue muscles; some of these myoblasts shift dorsally to form the intrinsic laryngeal muscles" [https://books.google.com/books?isbn=1455727911]
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Allelic Composition: Pax3Sp/Pax3Sp
Genetic Background: involves: C57BL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020647 Ncoa1 / P70365 / Nuclear receptor coactivator 1 / Q15788*  / complex / reaction






 

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