Manteia

ENSMUSG00000001497

Mus musculus

Features

Gene ID:	ENSMUSG00000001497

Biological name :	Pax9

Synonyms :	P47242 / Paired box protein Pax-9 / Pax9

Possible biological names infered from orthology :	P55771 / paired box 9

Species:	Mus musculus

Chr. number:	12
Strand:	1
Band:	C1
Gene start:	56691767
Gene end:	56712822

Corresponding Affymetrix probe sets:	10395849 (MoGene1.0st) 1421246_at (Mouse Genome 430 2.0 Array) 1421247_at (Mouse Genome 430 2.0 Array) 1442229_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000001538 Ensembl peptide - ENSMUSP00000117928 NCBI entrez gene - 18511 See in Manteia. MGI - MGI:97493 RefSeq - XM_017314991 RefSeq - NM_011041 RefSeq - XM_006515580 RefSeq - XM_006515581 RefSeq - XM_011244013 RefSeq - XM_006515579 RefSeq Peptide - NP_035171 swissprot - P47242 swissprot - Q3V1K1 Ensembl - ENSMUSG00000001497

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
pax9	ENSDARG00000053829	Danio rerio
PAX9	ENSGALG00000010114	Gallus gallus
PAX9	ENSG00000198807	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Pax1 / P09084 / Paired box protein Pax-1 / P15863* / paired box 1*	ENSMUSG00000037034	64
Pax3 / P24610 / paired box 3 / P23760*	ENSMUSG00000004872	39
Pax8 / Q00288 / Paired box protein Pax-8 / Q06710* / paired box 8*	ENSMUSG00000026976	37
Pax2 / paired box 2 / Q02962*	ENSMUSG00000004231	37
Pax7 / P47239 / Paired box protein Pax-7 / P23759* / paired box 7*	ENSMUSG00000028736	36
Pax6 / P63015 / Paired box protein Pax-6 / P26367* / paired box 6*	ENSMUSG00000027168	36
Pax5 / Q02650 / Paired box protein Pax-5 / Q02548* / paired box 5*	ENSMUSG00000014030	35
Pax4 / P32115 / paired box 4 / O43316*	ENSMUSG00000029706	29

Protein motifs (from Interpro)

Interpro ID	Name
IPR001523	Paired domain
IPR009057	Homeobox-like domain superfamily
IPR033204	Paired box protein PAX9
IPR036388	Winged helix-like DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	TAS
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007492	endoderm development	IMP
biological_process	GO:0009887	animal organ morphogenesis	TAS
biological_process	GO:0042476	odontogenesis	IGI
biological_process	GO:0042481	regulation of odontogenesis	IGI
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	ISO
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0060325	face morphogenesis	IGI
biological_process	GO:0071363	cellular response to growth factor stimulus	IDA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005667	transcription factor complex	TAS
molecular_function	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IMP
molecular_function	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	TAS

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000030	abnormal tympanic ring morphology	"malformed bony ring at the ear canal to which the tympanic membrane is attached" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]	Show Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt,Tg(Pgk1-cre)1Lni/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
MP:0000090	absent premaxilla	"missing anterior and interior portion of the maxilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt,Tg(Pgk1-cre)1Lni/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL
MP:0000094	absent alveolar process	"missing projecting ridge on the inferior surface of the body of the maxilla containing the tooth sockets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL
MP:0000116	abnormal tooth development	"anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ntrk2^tm1Lfp/Ntrk2^tm1Lfp Genetic Background: involves: 129 Allelic Composition: Pax9^tm1Hpt/Pax9^tm1Rbal Genetic Background: involves: 129 * C57BL/6 * CD-1 Allelic Composition: Osr2^tm1Jian/Osr2^tm1Jian,Pax9^{tm1.1(Osr2)Jian}/Pax9⁺ Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N
MP:0000118	arrest of tooth development	"failure of differentiation of the teeth" [J:18378]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified Allelic Composition: Pax9^tm1Hpt/Pax9^tm1Rbal Genetic Background: involves: 129 * C57BL/6 * CD-1 Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL Allelic Composition: Pax9^{tm1.1(Osr2)Jian}/Pax9^{tm1.1(Osr2)Jian} Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N
MP:0000121	failure of tooth eruption	"inability of the teeth to grow into the oral cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Pax9^tm1Hpt/Pax9^tm1Hpt Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Pax9^tm1Hpt/Pax9^tm1Rbal Genetic Background: involves: 129 * C57BL/6 * CD-1
MP:0000124	absent teeth	"missing bony structures of the upper and lower jaws used in mastication" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified Allelic Composition: Pax9^tm1Hpt/Pax9^tm1Hpt Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Pax9^tm1Hpt/Pax9^tm1Rbal Genetic Background: involves: 129 * C57BL/6 * CD-1 Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt,Tg(Pgk1-cre)1Lni/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL
MP:0000125	absent incisors	"missing long pointed teeth; most anterior and prominent in the jaw" [J:17489]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0000128	growth retardation of molars	"developmental delay of the growth of the molars" [J:17489]	Show Allelic Composition: Pax9^tm1Hpt/Pax9^tm1Rbal Genetic Background: involves: 129 * C57BL/6 * CD-1
MP:0000430	absent maxillary shelf	"missing outgrowth of the maxilla; normally fuses with palatine shelf to form secondary palate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0000431	absent palatine shelf	"missing outgrowth of the palatine bone; normally fuses with maxillary shelf to form secondary palate " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0000438	abnormal skull morphology	"anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0000458	abnormal mandible morphology	"malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified Allelic Composition: Pax9^{tm1.1(Osr2)Jian}/Pax9^{tm1.1(Osr2)Jian} Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N
MP:0000562	polydactyly	"greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt,Tg(Pgk1-cre)1Lni/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
MP:0000680	absent parathyroid glands	"missing the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland, which secrete parathyroid hormone (PTH) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt,Tg(Pgk1-cre)1Lni/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
MP:0000705	athymia	"absence of the primary lymphoid organ" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Pax9^tm1Hpt/Pax9^tm1Hpt Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001270	distended abdomen	"abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0001438	aphagia	"inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]	Show Allelic Composition: Plpp3^tm3.1Stw/Plpp3^tm3.1Stw Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0002100	abnormal tooth morphology	"atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ntrk2^tm1Lfp/Ntrk2^tm1Lfp Genetic Background: involves: 129
MP:0002116	abnormal craniofacial bone morphology	"abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dkk1^tm1.1Svo/Dkk1^tm1.2Svo,Pax3^tm1(cre)Joe/Pax3⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Plpp3^tm3.1Stw/Plpp3^tm3.1Stw Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0002256	abnormal laryngeal cartilage morphology	"any structural anomaly of the cartilagenous structures that support the larynx" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0002260	abnormal thyroid cartilage morphology	"any structural anomaly of the largest of the laryngeal cartilages " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0002367	abnormal thymus lobule morphology	"anomalous structure or development of the basic structural unit of the thymus" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt,Tg(Pgk1-cre)1Lni/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
MP:0002650	abnormal ameloblast morphology	"malformation of the epithelial cells of the inner layer of the enamel organ of the developing tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Pax9^tm1Hpt/Pax9^tm1Rbal Genetic Background: involves: 129 * C57BL/6 * CD-1
MP:0002689	abnormal molar morphology	"structural defect of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [il:Ira Lu , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pax9^tm1Hpt/Pax9^tm1Hpt Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Pax9^tm1Hpt/Pax9^tm1Rbal Genetic Background: involves: 129 * C57BL/6 * CD-1
MP:0002818	abnormal dentin morphology	"defects in the hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pax9^tm1Hpt/Pax9^tm1Hpt Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0003358	abnormal hypaxial muscle morphology	"malformation of the muscles of the limbs" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0003404	absent enamel	"absence of the hard outer coating of the exposed portion of the tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:92017]	Show Allelic Composition: Pax9^tm1Hpt/Pax9^tm1Rbal Genetic Background: involves: 129 * C57BL/6 * CD-1
MP:0003931	absent molars	"missing the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified Allelic Composition: Pax9^tm1Hpt/Pax9^tm1Rbal Genetic Background: involves: 129 * C57BL/6 * CD-1
MP:0004083	polysyndactyly	"greater than 5 digits present on an autopod with interdigital webbing also present" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0004452	abnormal pterygoid process morphology	"any structural anomaly of the process projecting downward from either side of the sphenoid bone, in vertebrates divided into two plates, an inner and an outer (sometimes called the lateral and medial); the posterior nares pass through the space, called the pterygoid fossa, between the processes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0004537	abnormal palatine shelf	"any structural anomaly of the palatine bone; normally fuses with maxillary shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt,Tg(Pgk1-cre)1Lni/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL
MP:0004538	abnormal maxillary shelf	"any structural anomaly of the outgrowth of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt,Tg(Pgk1-cre)1Lni/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL
MP:0004592	small mandible	"reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Pax9^{tm1.1(Osr2)Jian}/Pax9^{tm1.1(Osr2)Jian} Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N
MP:0004791	absent lower incisors	"missing the lower pair of long pointed teeth that are the most anterior and prominent in the jaw" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax9^tm1Hpt/Pax9^tm1Hpt Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Pax9^tm1Hpt/Pax9^tm1Rbal Genetic Background: involves: 129 * C57BL/6 * CD-1
MP:0004912	absent mandibular coronoid process	"absence of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt,Tg(Pgk1-cre)1Lni/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL Allelic Composition: Pax9^{tm1.1(Osr2)Jian}/Pax9^{tm1.1(Osr2)Jian} Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N
MP:0004914	absent ultimobranchial body	"absence of the sac-like structure emanating from the caudal-most branchial pouch of the embryo which develops into the lateral portion of the thyroid" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0004915	abnormal Reichert s cartilage	"any structural abnormality of the cartilage found in the mesenchyme of the second pharyngeal arch in the embryo from which develop the stapes, styloid process, lesser horn and upper part of the body of the hyoid bone; its proximal end gives rise to the stylohyoid ligament" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0004916	absent Reichert cartilage	"absence of the cartilage normally found in the mesenchyme of the second branchial arch in the embryo, from which develop the stapes, the styloid processes, the stylohyoid ligaments, and the lesser cornua of the hyoid bone" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0005503	abnormal tendon morphology	"structural anomaly of the fibrous bands or cords of connective tissue at the ends of muscle fibers that attach muscles to bones and other structures" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:45509]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0006020	reduced size of tympanic ring	"smaller than average tympanic ring" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified Allelic Composition: Pax9^{tm1.1(Osr2)Jian}/Pax9^{tm1.1(Osr2)Jian} Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N
MP:0006031	abnormal branchial pouch morphology	"malfomation or anomaly in the series of grooves that form between the branchial arches; these endodermal evaginations develop into epithelial tissues and organs" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0006279	abnormal limb development	"anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0006400	decreased molar number	"reduction in the number of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax9^tm1Hpt/Pax9^tm1Hpt Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0009655	abnormal secondary palate development	"any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified Allelic Composition: Pax9^{tm1.1(Osr2)Jian}/Pax9^{tm1.1(Osr2)Jian} Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N
MP:0009743	preaxial polydactyly	"duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]	Show Allelic Composition: Pax9^{tm1.1(Osr2)Jian}/Pax9^{tm1.1(Osr2)Jian} Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N
MP:0009885	abnormal palatal shelf elevation	"any anomaly in the process in which the palatal shelves move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified
MP:0009886	failure of palatal shelf elevation	"the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]	Show Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL
MP:0009888	palatal shelves fail to meet at midline	"polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]	Show Allelic Composition: Pax9^{tm1.1(Osr2)Jian}/Pax9^{tm1.1(Osr2)Jian} Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N
MP:0009890	cleft secondary palate	"congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt,Tg(Pgk1-cre)1Lni/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL Allelic Composition: Pax9^{tm1.1(Osr2)Jian}/Pax9^{tm1.1(Osr2)Jian} Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N Allelic Composition: Osr2^tm1Jian/Osr2^tm1Jian,Pax9^{tm1.2(Osr2)Jian}/Pax9⁺ Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6J * FVB/N Allelic Composition: Osr2^tm1Jian/Osr2^tm1Jian,Pax9^{tm1.1(Osr2)Jian}/Pax9⁺ Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Pax9^tm1Hpt/Pax9^tm1Rbal Genetic Background: involves: 129 * C57BL/6 * CD-1
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Tfap2a^tm2Will/Tfap2a^tm2Will,Hhat^{Tg(TFAP2A-cre)1Will}/0 Genetic Background: Not Specified Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt,Tg(Pgk1-cre)1Lni/? Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL Allelic Composition: Pax9^{tm1.1(Osr2)Jian}/Pax9^{tm1.1(Osr2)Jian} Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N
MP:0030136	abnormal lower incisor morphology	"any structural anomaly of the lower set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]	Show Allelic Composition: Dkk1^tm1.1Svo/Dkk1^tm1.2Svo,Pax3^tm1(cre)Joe/Pax3⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
MP:0030459	abnormal tooth attrition	"change in the physiologic wearing away of tooth structure as a result of abnormal tooth-to-tooth contact, as in mastication, occurring only on the occlusal, incisal, and proximal surfaces" [PMID:22240686, RDO:0007259]	Show Allelic Composition: Pax9^tm1Hpt/Pax9^tm1Hpt Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Pax9^tm1Hpt/Pax9^tm1Rbal Genetic Background: involves: 129 * C57BL/6 * CD-1
MP:0030542	abnormal dentin development	"any anomaly in the process whose specific outcome is the formation of dentin, the hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root; dentinogenesis begins prior to enamel formation and is initiated by the odontoblasts of the dental pulp; dentin is derived from the dental papilla of the tooth germ; after apposition of predentin and maturation into dentin, the cell bodies of the odontoblasts remain in the pulp inside the tooth, along its outer wall; unlike enamel, dentin continues to form throughout life and can be initiated in response to stimuli, such as tooth decay or attrition" [GO:0097187, https://en.wikipedia.org/wiki/Dentin]	Show Allelic Composition: Pax9^tm1Hpt/Pax9^tm1Rbal Genetic Background: involves: 129 * C57BL/6 * CD-1

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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