Manteia

ENSMUSG00000026976

Mus musculus

Features

Gene ID:	ENSMUSG00000026976

Biological name :	Pax8

Synonyms :	Paired box protein Pax-8 / Pax8 / Q00288

Possible biological names infered from orthology :	paired box 8 / Q06710

Species:	Mus musculus

Chr. number:	2
Strand:	-1
Band:	A3
Gene start:	24420560
Gene end:	24475599

Corresponding Affymetrix probe sets:	10480477 (MoGene1.0st) 1418208_at (Mouse Genome 430 2.0 Array) 1446561_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000134343 Ensembl peptide - ENSMUSP00000115194 Ensembl peptide - ENSMUSP00000120319 Ensembl peptide - ENSMUSP00000133316 Ensembl peptide - ENSMUSP00000028355 NCBI entrez gene - 18510 See in Manteia. MGI - MGI:97492 RefSeq - XM_006497781 RefSeq - NM_011040 RefSeq - XM_006497778 RefSeq - XM_006497779 RefSeq - XM_006497780 RefSeq Peptide - NP_035170 swissprot - Q00288 swissprot - A2AIU8 swissprot - G3UZ49 swissprot - A2AIU7 swissprot - A2AIU6 Ensembl - ENSMUSG00000026976

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
pax8	ENSDARG00000015879	Danio rerio
PAX8	ENSG00000125618	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Pax2 / paired box 2 / Q02962*	ENSMUSG00000004231	54
Pax5 / Q02650 / Paired box protein Pax-5 / Q02548* / paired box 5*	ENSMUSG00000014030	52
Pax7 / P47239 / Paired box protein Pax-7 / P23759* / paired box 7*	ENSMUSG00000028736	33
Pax3 / P24610 / paired box 3 / P23760*	ENSMUSG00000004872	32
Pax6 / P63015 / Paired box protein Pax-6 / P26367* / paired box 6*	ENSMUSG00000027168	32
Pax1 / P09084 / Paired box protein Pax-1 / P15863* / paired box 1*	ENSMUSG00000037034	31
Pax9 / P47242 / Paired box protein Pax-9 / P55771* / paired box 9*	ENSMUSG00000001497	27
Pax4 / P32115 / paired box 4 / O43316*	ENSMUSG00000029706	25

Protein motifs (from Interpro)

Interpro ID	Name
IPR001523	Paired domain
IPR009057	Homeobox-like domain superfamily
IPR022130	Paired-box protein 2 C-terminal
IPR036388	Winged helix-like DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001655	urogenital system development	IGI
biological_process	GO:0001656	metanephros development	IEP
biological_process	GO:0001658	branching involved in ureteric bud morphogenesis	IEA
biological_process	GO:0001822	kidney development	IEA
biological_process	GO:0001823	mesonephros development	IMP
biological_process	GO:0003281	ventricular septum development	IMP
biological_process	GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0006790	sulfur compound metabolic process	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007417	central nervous system development	IEA
biological_process	GO:0009887	animal organ morphogenesis	TAS
biological_process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	IMP
biological_process	GO:0030154	cell differentiation	IMP
biological_process	GO:0030878	thyroid gland development	IEP
biological_process	GO:0039003	pronephric field specification	IEP
biological_process	GO:0042472	inner ear morphogenesis	IGI
biological_process	GO:0042981	regulation of apoptotic process	IMP
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0048793	pronephros development	IMP
biological_process	GO:0071371	cellular response to gonadotropin stimulus	IEA
biological_process	GO:0071599	otic vesicle development	IEA
biological_process	GO:0072050	S-shaped body morphogenesis	IEP
biological_process	GO:0072073	kidney epithelium development	IEP
biological_process	GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	IMP
biological_process	GO:0072164	mesonephric tubule development	IEP
biological_process	GO:0072207	metanephric epithelium development	IEA
biological_process	GO:0072221	metanephric distal convoluted tubule development	IMP
biological_process	GO:0072278	metanephric comma-shaped body morphogenesis	IEA
biological_process	GO:0072284	metanephric S-shaped body morphogenesis	IEA
biological_process	GO:0072289	metanephric nephron tubule formation	IMP
biological_process	GO:0072305	negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis	IMP
biological_process	GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation	IMP
biological_process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	IMP
biological_process	GO:1900212	negative regulation of mesenchymal cell apoptotic process involved in metanephros development	IMP
biological_process	GO:1900215	negative regulation of apoptotic process involved in metanephric collecting duct development	IMP
biological_process	GO:1900218	negative regulation of apoptotic process involved in metanephric nephron tubule development	IMP
biological_process	GO:2000594	positive regulation of metanephric DCT cell differentiation	IMP
biological_process	GO:2000611	positive regulation of thyroid hormone generation	IEA
biological_process	GO:2000612	regulation of thyroid-stimulating hormone secretion	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005667	transcription factor complex	TAS
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	IEA
molecular_function	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	IEA
molecular_function	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0043565	sequence-specific DNA binding	IEA
molecular_function	GO:0044212	transcription regulatory region DNA binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000018	small ears	"outer ears of a smaller than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0000042	abnormal organ of Corti	"abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0000049	abnormal middle ear morphology	"malformation or malfunction of any components of the tympanic cavity or its ossicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gdf5^bp/Gdf5^bp Genetic Background: Swiss albino stock
MP:0000054	delayed ear emergence	"late onset of the growth of the outer ear" [J:49421]	Show Allelic Composition: Pax8^tm1Rdl/Pax8^{tm1.1(cre)Mbu} Genetic Background: B6.129(Cg)-Pax8^tm1Rdl Pax8^{tm1.1(cre)Mbu}
MP:0000060	delayed bone ossification	"late onset of the formation of bone" [J:40203]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0000135	reduced cortical bone thickness	"thinner than normal superficial layer of compact bone " [J:61509]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0000519	hydronephrosis	"dilation of the pelvis and calices of one or both kidneys" [J:56641]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2(Rnf187)Jhai}/Gt(ROSA)26Sor⁺,Kras^tm4Tyj/Kras⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2
MP:0000522	cysts in kidney cortex	"abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]	Show Allelic Composition: Dicer1^tm1Smr/Dicer1^tm1Smr,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0000527	abnormal kidney development	"anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Krt17^tm1Cou/Krt17^tm1Cou Genetic Background: B6.129S2(D2)-Krt1-17^tm1Cou
MP:0000547	short limbs	"reduced average length of the extremities" [MGI:CLS, J:61509]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0000681	abnormal thyroid gland morphology	"anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gdf5^bp/Gdf5^bp Genetic Background: Swiss albino stock Allelic Composition: Pax8^tm1Rdl/Pax8^{tm1.1(cre)Mbu} Genetic Background: B6.129(Cg)-Pax8^tm1Rdl Pax8^{tm1.1(cre)Mbu}
MP:0001121	uterine hypoplasia	"reduced size of the uterus due to decreased cell number" [J:45065]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0001136	dilated cervix	"stretched or enlarged lower opening of the uterus to the vagina" [J:50844]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0001144	fused vaginal opening	"condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Krt17^tm1Cou/Krt17^tm1Cou Genetic Background: B6.129S2(D2)-Krt1-17^tm1Cou Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0001155	arrest of spermatogenesis	"block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Pax8^tm1Rdl/Pax8^{tm1.1(cre)Mbu} Genetic Background: B6.129(Cg)-Pax8^tm1Rdl Pax8^{tm1.1(cre)Mbu} Allelic Composition: Dicer1^tm1Smr/Dicer1^tm1Smr,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Pax8^tm1Rdl/Pax8^{tm1.1(cre)Mbu} Genetic Background: B6.129(Cg)-Pax8^tm1Rdl Pax8^{tm1.1(cre)Mbu}
MP:0001290	delayed eyelid opening	"late average time for the first postnatal eye opening" [J:17792]	Show Allelic Composition: Pax8^tm1Rdl/Pax8^{tm1.1(cre)Mbu} Genetic Background: B6.129(Cg)-Pax8^tm1Rdl Pax8^{tm1.1(cre)Mbu}
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Itgb2^tm1Bay/Itgb2^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * PL/J Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0001762	polyuria	"increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Sestd1^tm1.1Bnrc/Sestd1⁺,Vangl2^Lp/Vangl2⁺ Genetic Background: involves: 129S6/SvEvTac * A * C57BL/6NCr Allelic Composition: Gal3st1^tm1.1Hjg/Gal3st1^tm1.1Hjg,Ugcg^tm1Hjg/Ugcg^tm1Hjg,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Dicer1^tm1Smr/Dicer1^tm1Smr,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Krt17^tm1Cou/Krt17^tm1Cou Genetic Background: B6.129S2(D2)-Krt1-17^tm1Cou
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0001967	deafness	"inability to hear" [J:57651]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gdf5^bp/Gdf5^bp Genetic Background: Swiss albino stock Allelic Composition: Pax8^tm1Rdl/Pax8^{tm1.1(cre)Mbu} Genetic Background: B6.129(Cg)-Pax8^tm1Rdl Pax8^{tm1.1(cre)Mbu}
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Snrk^tm2Rra/Snrk⁺,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: C57BL/6J * FVB/N
MP:0002177	abnormal outer ear morphology	"malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gdf5^bp/Gdf5^bp Genetic Background: Swiss albino stock
MP:0002622	abnormal cochlear hair cell morphology	"malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0002660	abnormal caput	"anomalous structure of the head of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0002661	abnormal corpus	"anomalous structure of the body of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0002705	dilated renal tubules	"enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dicer1^tm1Smr/Dicer1^tm1Smr,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0002827	abnormal renal corpuscle	"anomalous structure or development of either Bowman s capsules and/or the glomeruli contained therein" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Dicer1^tm1Smr/Dicer1^tm1Smr,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0002871	albuminuria	"presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Dicer1^tm1Smr/Dicer1^tm1Smr,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0002902	hypophosphaturia	"a reduction of excretion of phosphates in the urine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2(Rnf187)Jhai}/Gt(ROSA)26Sor⁺,Kras^tm4Tyj/Kras⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2
MP:0002951	small thyroid gland	"reduced size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) Allelic Composition: Pax8^tm1Rdl/Pax8^{tm1.1(cre)Mbu} Genetic Background: B6.129(Cg)-Pax8^tm1Rdl Pax8^{tm1.1(cre)Mbu}
MP:0002962	increased protein excretion	"greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]	Show Allelic Composition: Dicer1^tm1Smr/Dicer1^tm1Smr,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0002963	decreased protein excretion	"less than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2(Rnf187)Jhai}/Gt(ROSA)26Sor⁺,Kras^tm4Tyj/Kras⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2
MP:0002988	decreased urine osmolarity	"reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]	Show Allelic Composition: Dicer1^tm1Smr/Dicer1^tm1Smr,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0002998	abnormal bone remodeling	"aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0003014	abnormal kidney medulla morphology	"anomalous structure of the inner portion of the kidney consisting of the renal pyramids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:88636, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2(Rnf187)Jhai}/Gt(ROSA)26Sor⁺,Kras^tm4Tyj/Kras⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2
MP:0003205	testicular atrophy	"wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0003215	renal interstitial fibrosis	"formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]	Show Allelic Composition: Dicer1^tm1Smr/Dicer1^tm1Smr,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0003419	delayed endochondral bone ossification	"late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0003421	abnormal thyroid gland development	"failure or abnormality in the formation of the thyroid gland during organogenesis" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95017]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0003446	renal hypoplasia	"decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Krt17^tm1Cou/Krt17^tm1Cou Genetic Background: B6.129S2(D2)-Krt1-17^tm1Cou
MP:0003503	decreased activity of thyroid		Show Allelic Composition: Pax8^tm1Rdl/Pax8^{tm1.1(cre)Mbu} Genetic Background: B6.129(Cg)-Pax8^tm1Rdl Pax8^{tm1.1(cre)Mbu}
MP:0003534	blind vagina	"presence the female reproductive canal that ends in a sac and does not connect to internal genitalia" [ncbi:Matthew Mailman, NCBI request, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Krt17^tm1Cou/Krt17^tm1Cou Genetic Background: B6.129S2(D2)-Krt1-17^tm1Cou
MP:0003557	absent vas deferens	"absence of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ret^tm1Cos/Ret⁺ Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ
MP:0003572	abnormal uterus development	"abnormal morphogenesis of the female muscular organ of gestation" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0003620	decreased urine output	"decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2(Rnf187)Jhai}/Gt(ROSA)26Sor⁺,Kras^tm4Tyj/Kras⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2
MP:0003670	dilated glomerular capsule	"an expansion in volume of the expanded beginning of a nephron that contains the glomerulus" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:91499]	Show Allelic Composition: Dicer1^tm1Smr/Dicer1^tm1Smr,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0003722	absent ureter	"missing the tube that conducts the urine from the renal pelvis to the bladder" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pax2^tm1Mbu/Pax2⁺,Pax8^tm1(cre)Mbu/Pax8^tm1(cre)Mbu Genetic Background: involves: 129P2/OlaHsd * C3H/He * C57BL/6
MP:0003825	abnormal pillar cell morphology	"abnormalities of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0003826	abnormal Mullerian duct morphology	"malformation of the transient embryonic tubes that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0003870	decreased urine glucose level	"a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2(Rnf187)Jhai}/Gt(ROSA)26Sor⁺,Kras^tm4Tyj/Kras⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2
MP:0003918	decreased kidney weight	"reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]	Show Allelic Composition: Dicer1^tm1Smr/Dicer1^tm1Smr,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0004041	increased susceptibility to kidney reperfusion injury	"an increased likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia " [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Irf9^M1Btlr/Irf9⁺ Genetic Background: C57BL/6J-Irf9^M1Btlr
MP:0004163	abnormal adenophysis morphology	"any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0004193	abnormal kidney papilla morphology	"any structural anomaly of the apex of the renal pyramid that projects into a calyx" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gal3st1^tm1.1Hjg/Gal3st1^tm1.1Hjg,Ugcg^tm1Hjg/Ugcg^tm1Hjg,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004404	cochlear outer hair cell degeneration	"degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0004433	abnormal cochlear inner hair cell physiology	"anomalies in processes pertinent to the function of cochlear IHCs which constitute the true sensory cell type sending impulses via the cochlear (auditory) nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0004505	decreased renal glomerulus number	"reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Krt17^tm1Cou/Krt17^tm1Cou Genetic Background: B6.129S2(D2)-Krt1-17^tm1Cou
MP:0004521	abnormal cochlear hair cell stereociliary bundle morphology	"any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0004527	abnormal outer hair cell stereociliary bundle morphology	"any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0004562	abnormal inner hair cell synaptic ribbon morphology	"any structural abnormality in the presynaptic active zone of mature cochlear IHCs which usually contain a single synaptic ribbon, i.e. a submicrometer, electron-dense structure tethering synaptic vesicles; each spiral ganglion neuron receives input from only one IHC synapse" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0004591	enlarged tectorial membrane	"increased size of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0004633	abnormal cochlear IHC efferent innervation	"any changes in the morphology of the normally dense plexus of efferent terminals that contact radial fibers of the spiral ganglion below cochlear IHCs or of the sparser plexus of terminals positioned around IHC somata; normally, lateral olivocochlear neurons, which are found in and/or around the lateral superior olive, project mainly to the ipsilateral cochlea and terminate mostly on dendritic fibers below IHCs " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0004660	absent thyroid follicular cells	"absence of the thyroxine-producing follicular cells derived from the thyroid diverticulum which evaginates from the endodermal epithelium of the embryonic pharyngeal floor" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0004662	abnormal thyroid diverticulum	"any structural abnormality in the endodermal bud derived from the endodermal epithelium of the embryonic pharyngeal floor" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0004664	delayed inner ear development	"slowed progression to structurally mature components of the labyrinth, including the semicircular canals, vestibule and cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0004665	abnormal stapedial artery morphology	"any structural abnormality in the small artery that passes through the ring of the stapes; while the stapedial artery is a temporary artery thought to disappear at late embryonic stage in humans, the mouse stapedial artery is complete by E13 and persists into adulthood " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0004666	absent stapedial artery	"absence of the small artery that passes through the ring of the stapes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0004696	abnormal thyroid follicle morphology	"any structural abnormality of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Pax8^tm1Rdl/Pax8^{tm1.1(cre)Mbu} Genetic Background: B6.129(Cg)-Pax8^tm1Rdl Pax8^{tm1.1(cre)Mbu}
MP:0004697	abnormal thyroid follicular cell	"any structural anomaly of the thyroxine-producing follicular cells derived from the thyroid diverticulum which evaginates from the endodermal epithelium of the embryonic pharyngeal floor" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax8^tm1Rdl/Pax8^{tm1.1(cre)Mbu} Genetic Background: B6.129(Cg)-Pax8^tm1Rdl Pax8^{tm1.1(cre)Mbu}
MP:0004727	absent epididymis	"absence of the elongated structure connected to the posterior surface of the testis, consisting of the head, body, and tail, which turns sharply on itself to become the ductus deferens (vas deferens)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0004729	absent efferent ductules of testis	"absence of the small seminal ducts that lead from the testis to the head of the epididymis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0004852	decreased testis weight	"reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0004930	small epididymis	"decrease in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0004933	abnormal epididymis epithelium morphology	"any structural anomaly of the layer of secretory cells which lines the epididymis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0004969	pale kidney	"kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dicer1^tm1Smr/Dicer1^tm1Smr,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0005105	abnormal middle ear ossicle morphology	"anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0005107	abnormal stapes morphology	"structural anomaly of the smallest and innermost of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0005122	increased circulating thyroid-stimulating hormone level	"greater than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) Allelic Composition: Pax8^tm1Rdl/Pax8^{tm1.1(cre)Mbu} Genetic Background: B6.129(Cg)-Pax8^tm1Rdl Pax8^{tm1.1(cre)Mbu}
MP:0005135	increased thyroid-stimulating hormone level	"less than expected concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0005314	absent thyroid gland	" missing endocrine gland that is normally located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30559]	Show Allelic Composition: Itgb2^tm1Bay/Itgb2^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * PL/J
MP:0005325	abnormal glomerulus	"anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dicer1^tm1Smr/Dicer1^tm1Smr,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0005402	abnormal action potential	"change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0005441	hypercalciuria	"excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2(Rnf187)Jhai}/Gt(ROSA)26Sor⁺,Kras^tm4Tyj/Kras⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2
MP:0005478	decreased circulating thyroxine level	"less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) Allelic Composition: Pax8^tm1Rdl/Pax8^{tm1.1(cre)Mbu} Genetic Background: B6.129(Cg)-Pax8^tm1Rdl Pax8^{tm1.1(cre)Mbu}
MP:0005479	decreased circulating triiodothyronine level	"less than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0005528	decreased glomerular filtration rate	"less than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dicer1^tm1Smr/Dicer1^tm1Smr,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0005579	absent outer ear	"missing auricles or external acoustic meatus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:17694]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0005618	decreased potassium excretion	"less than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2(Rnf187)Jhai}/Gt(ROSA)26Sor⁺,Kras^tm4Tyj/Kras⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2
MP:0005619	increased potassium excretion	"greater than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Sestd1^tm1.1Bnrc/Sestd1⁺,Vangl2^Lp/Vangl2⁺ Genetic Background: involves: 129S6/SvEvTac * A * C57BL/6NCr Allelic Composition: Gal3st1^tm1.1Hjg/Gal3st1^tm1.1Hjg,Ugcg^tm1Hjg/Ugcg^tm1Hjg,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0006033	abnormal external auditory canal	"malformation of the canal that connects the outer and middle ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0006042	increased apoptosis	"greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ctnna1^tm1Efu/Ctnna1^tm1Efu,Twist2^tm1(cre)Dor/Twist2⁺ Genetic Background: involves: 129X1/SvJ Allelic Composition: Pax8^tm1Rdl/Pax8^{tm1.1(cre)Mbu} Genetic Background: B6.129(Cg)-Pax8^tm1Rdl Pax8^{tm1.1(cre)Mbu}
MP:0006317	decreased urine sodium level	"lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2(Rnf187)Jhai}/Gt(ROSA)26Sor⁺,Kras^tm4Tyj/Kras⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2
MP:0006395	abnormal epiphyseal plate morphology	"any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0008257	thin myometrium	"reduced thickness of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" [MESH:A02.633.570.500, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0008329	decreased somatotroph cell number	"reduced number of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [CL:0000295, MESH:A06.407.747.608.937]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0008332	decreased lactotroph cell number	"reduced number of an acidophilic cell of the anterior pituitary that produces prolactin" [CL:0000439, MESH:A06.407.747.608.812]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0008337	increased thyrotroph cell number	"greater number of an anterior pituitary cell that produces thyroid-stimulating hormone" [MESH:A06.407.747.608.968]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0009069	dilated oviduct	"an expansion in the volume or area of the tube through which the ova pass from the ovary to the uterus, usually with an increase in contained fluid" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0009215	absent uterine horn	"absence of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0009224	absent endometrium	"absence of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MESH:A05.360.319.679.490, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0009350	decreased urine pH	"increased urine acidity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sestd1^tm1.1Bnrc/Sestd1⁺,Vangl2^Lp/Vangl2⁺ Genetic Background: involves: 129S6/SvEvTac * A * C57BL/6NCr Allelic Composition: Gal3st1^tm1.1Hjg/Gal3st1^tm1.1Hjg,Ugcg^tm1Hjg/Ugcg^tm1Hjg,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ugcg^tm1Hjg/Ugcg^tm1Hjg,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009640	abnormal renal tubule epithelium morphology	"any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Irf9^M1Btlr/Irf9⁺ Genetic Background: C57BL/6J-Irf9^M1Btlr Allelic Composition: Pax8^{tm1.1(cre)Mbu}/Pax8⁺,Plxnb1^tm1Rkun/Plxnb1^tm1Rkun,Plxnb2^tm1.1Rkun/Plxnb2^tm1.1Rkun Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009643	abnormal urine homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sestd1^tm1.1Bnrc/Sestd1⁺,Vangl2^Lp/Vangl2⁺ Genetic Background: involves: 129S6/SvEvTac * A * C57BL/6NCr Allelic Composition: Gal3st1^tm1.1Hjg/Gal3st1^tm1.1Hjg,Ugcg^tm1Hjg/Ugcg^tm1Hjg,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010867	abnormal bone trabecula morphology	"any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0010876	decreased bone volume	"reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0010984	abnormal metanephric mesenchyme morphology	"any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing metanephros; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:19828308]	Show Allelic Composition: Krt17^tm1Cou/Krt17^tm1Cou Genetic Background: B6.129S2(D2)-Krt1-17^tm1Cou
MP:0011060	abnormal kinocilium morphology	"any structural anomaly of the nonmotile primary cilium that is found at the apical surface of auditory receptor cells" [GO:0060091]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0011066	abnormal renal tubule epithelial cell primary cilium morphology	"any structural anomaly of the single non-motile cilium of a renal tubule epithelial cell that projects into the luminal space of the tubules where it is thought to act as a flow sensor" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17995581]	Show Allelic Composition: Dicer1^tm1Smr/Dicer1^tm1Smr,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0011083	complete lethality at weaning	"premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]	Show Allelic Composition: Itgb2^tm1Bay/Itgb2^tm1Bay Genetic Background: involves: 129S7/SvEvBrd * PL/J Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0011290	decreased nephron number	"reduction in the total number of filtering units of the kidney" [MGI:anna]	Show Allelic Composition: Krt17^tm1Cou/Krt17^tm1Cou Genetic Background: B6.129S2(D2)-Krt1-17^tm1Cou
MP:0011365	small metanephros	"reduced size of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord" [MGI:anna]	Show Allelic Composition: Krt17^tm1Cou/Krt17^tm1Cou Genetic Background: B6.129S2(D2)-Krt1-17^tm1Cou
MP:0011366	absent metanephros	"absence of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord" [MGI:anna]	Show Allelic Composition: Pax2^tm1Mbu/Pax2⁺,Pax8^tm1(cre)Mbu/Pax8^tm1(cre)Mbu Genetic Background: involves: 129P2/OlaHsd * C3H/He * C57BL/6
MP:0011368	increased kidney apoptosis	"increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Dicer1^tm1Smr/Dicer1^tm1Smr,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0011440	increased kidney cell proliferation	"increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2(Rnf187)Jhai}/Gt(ROSA)26Sor⁺,Kras^tm4Tyj/Kras⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2 Allelic Composition: Dicer1^tm1Smr/Dicer1^tm1Smr,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0011459	increased urine chloride ion level	"abnormally large amounts of chloride ion in the urine" [MGI:csmith]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2(Rnf187)Jhai}/Gt(ROSA)26Sor⁺,Kras^tm4Tyj/Kras⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2
MP:0011471	decreased urine creatinine level	"a reduced amount of creatinine in the urine compared to the normal state" [MGI:csmith]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2(Rnf187)Jhai}/Gt(ROSA)26Sor⁺,Kras^tm4Tyj/Kras⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2
MP:0011736	decreased urine ammonia level	"a reduced amount of ammonia in the urine compared to the normal state" [MGI:anna]	Show Allelic Composition: Sestd1^tm1.1Bnrc/Sestd1⁺,Vangl2^Lp/Vangl2⁺ Genetic Background: involves: 129S6/SvEvTac * A * C57BL/6NCr Allelic Composition: Gal3st1^tm1.1Hjg/Gal3st1^tm1.1Hjg,Ugcg^tm1Hjg/Ugcg^tm1Hjg,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011843	abnormal kidney collecting duct epithelium morphology	"any structural anomaly of the simple cuboidal epithelium lining the lumen of kidney collecting ducts; the mature and differentiated CD epithelium comprises two unique cells types with principal cells responsible for vasopressin-regulated water reabsorption, and intercalated cells regulating acid-base homeostasis; injury to the epithelium is believed to cause epithelial cells to acquire mesenchymal characteristics via epithelial-mesenchymal transition (EMT), a process through which tubular epithelial cells may transform into interstitial fibroblasts and promote renal fibrosis" [MGI:anna]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2(Rnf187)Jhai}/Gt(ROSA)26Sor⁺,Kras^tm4Tyj/Kras⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2
MP:0011846	decreased kidney collecting duct number	"smaller than expected number of the kidney ducts that collect urine from the distal convoluted tubules, merge and become larger as they descend from the renal cortex into the medulla, and respond to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance" [MGI:anna]	Show Allelic Composition: Dicer1^tm1Smr/Dicer1^tm1Smr,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0011858	elongated kidney papilla	"increased average length of the apex of the renal pyramid that projects into a calyx" [MGI:anna]	Show Allelic Composition: Gt(ROSA)26Sor^{tm2(Rnf187)Jhai}/Gt(ROSA)26Sor⁺,Kras^tm4Tyj/Kras⁺,Tg(Vil-cre)20Syr/0 Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2
MP:0011941	increased fluid intake	"increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Dicer1^tm1Smr/Dicer1^tm1Smr,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0012551	metabolic acidosis	"decreased pH and bicarbonate concentration in tissues and/or body fluids caused when the body produces too much acid or when the kidneys are not removing enough acid from the body, as in diarrhea or in kidney disease" [ISBN:0-683-40008-8]	Show Allelic Composition: Sestd1^tm1.1Bnrc/Sestd1⁺,Vangl2^Lp/Vangl2⁺ Genetic Background: involves: 129S6/SvEvTac * A * C57BL/6NCr
MP:0013305	isosthenuria	"inability of the kidneys to produce either a concentrated or a dilute urine; refers to a state in chronic renal disease in which the kidney cannot form urine with a higher or a lower specific gravity (concentration) than that of protein-free plasma; the specific gravity of the urine becomes fixed, irrespective of the fluid intake" [MGI:Anna]	Show Allelic Composition: Dicer1^tm1Smr/Dicer1^tm1Smr,Pax8^{tm1.1(cre)Mbu}/Pax8⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0013624	decreased femur compact bone thickness	"reduced width of the superficial layer of compact bone at the midpoint of the femur" [MGI:csmith]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0020010	decreased bone mineral density of femur	"reduction in the amount of mineral per square centimeter of bone (usually g/cm2) in the long bone of the thigh" [GOC:NV]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0020137	decreased bone mineralization	"decrease in the rate at which minerals are deposited into bone" []	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0030160	abnormal auditory bulla morphology	"any structural anomaly of the hollow bony structure on the ventral, posterior portion of the skull that encloses parts of the middle and inner ear; in most species, it is formed by the tympanic part of the temporal bone" [https://en.wikipedia.org/wiki/Tympanic_part_of_the_temporal_bone]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0030407	abnormal stapes crus morpholgy	"any structural anomaly of either of the two (anterior and posterior) limbs of the stapes that pass from the head to the base or footplate; in mice, the anterior crus is curved and the posterior crus is more straight whereas in humans, the anterior crus is more straight than the posterior crus" [https://medical-dictionary.thefreedictionary.com/anterior+crus+of+stapes, PMID:28117786]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0030411	small round window	"reduced size of the opening on the medial wall of the middle ear leading into the cochlea, closed in life by the secondary tympanic membrane; it serves to regulate fluid pressure in the inner ear" [MGI:anna]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
MP:0030412	absent round window	"absence of the opening on the medial wall of the middle ear leading into the cochlea, closed in life by the secondary tympanic membrane; it serves to regulate fluid pressure in the inner ear" [MGI:anna]	Show Allelic Composition: Pax8^tm1Pgr/Pax8^tm1Pgr Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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