ENSMUSG00000029706


Mus musculus

Features
Gene ID: ENSMUSG00000029706
  
Biological name :Pax4
  
Synonyms : P32115 / paired box 4 / Pax4
  
Possible biological names infered from orthology : O43316
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A3.3
Gene start: 28442334
Gene end: 28449353
  
Corresponding Affymetrix probe sets: 10543530 (MoGene1.0st)   1451598_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131301
Ensembl peptide - ENSMUSP00000134470
Ensembl peptide - ENSMUSP00000031718
Ensembl peptide - ENSMUSP00000126000
NCBI entrez gene - 18506     See in Manteia.
MGI - MGI:97488
RefSeq - XM_017321450
RefSeq - NM_001159925
RefSeq - NM_001159926
RefSeq - NM_011038
RefSeq Peptide - NP_001153398
RefSeq Peptide - NP_001153397
RefSeq Peptide - NP_035168
swissprot - P32115
swissprot - G3UZE8
swissprot - B7ZNC8
swissprot - A2RRY5
Ensembl - ENSMUSG00000029706
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pax4ENSDARG00000021336Danio rerio
 PAX4ENSG00000106331Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pax6 / P63015 / Paired box protein Pax-6 / P26367* / paired box 6*ENSMUSG0000002716843
Pax7 / P47239 / Paired box protein Pax-7 / P23759* / paired box 7*ENSMUSG0000002873635
Pax2 / paired box 2 / Q02962*ENSMUSG0000000423132
Pax3 / P24610 / paired box 3 / P23760*ENSMUSG0000000487232
Pax8 / Q00288 / Paired box protein Pax-8 / Q06710* / paired box 8*ENSMUSG0000002697632
Pax5 / Q02650 / Paired box protein Pax-5 / Q02548* / paired box 5*ENSMUSG0000001403030
Pax9 / P47242 / Paired box protein Pax-9 / P55771* / paired box 9*ENSMUSG0000000149728
Pax1 / P09084 / Paired box protein Pax-1 / P15863* / paired box 1*ENSMUSG0000003703427


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001523  Paired domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR033559  Paired box protein Pax-4
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031016 pancreas development IEA
 biological_processGO:0031018 endocrine pancreas development TAS
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045595 regulation of cell differentiation IMP
 biological_processGO:0045597 positive regulation of cell differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0060041 retina development in camera-type eye IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex TAS
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Rnf2tm1Mvi/Rnf2tm1Mvi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Rnf2tm1Mvi/Rnf2tm1Mvi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL

Allelic Composition: Pax4tm1Pgr/Pax4tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbc1d4tm1Lex/Tbc1d4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J * C57BL/6N

 MP:0002694 abnormal pancreas secretion "altered ability of the pancreas to release its products" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

 MP:0005568 increased circulating total protein level "greater than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0009174 absent pancreatic beta cells "absence of the cells of the pancreas that secrete insulin" [MESH:A03.734.414.131]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Rnf2tm1Mvi/Rnf2tm1Mvi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL

Allelic Composition: Pax4tm1Pgr/Pax4tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax4tm1Pgr/Pax4tm1.1Aman,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6 * SJL

 MP:0009176 increased pancreatic alpha cell number "increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
Show

Allelic Composition: Pax4tm1Pgr/Pax4tm1.1Aman,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6 * SJL

 MP:0009182 absent pancreatic delta cells "absence of the cells found in the pancreas that secrete somatostatin" [MESH:A03.556.875.875.440.854]
Show

Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

Allelic Composition: Pax4tm1(cre/ERT2)Sosa/Pax4tm1(cre/ERT2)Sosa
Genetic Background: Not Specified

Allelic Composition: Pax4tm1Pgr/Pax4tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax4tm1Pgr/Pax4tm1.1Aman,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6 * SJL

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tfap2atm1Hsv/Tfap2atm2Will,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: Not Specified

Allelic Composition: Pax4tm1(cre/ERT2)Sosa/Pax4tm1(cre/ERT2)Sosa
Genetic Background: Not Specified

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pax4tm1Pgr/Pax4tm1.1Aman,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6 * SJL

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Pax4tm1Pgr/Pax4tm1.1Aman,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6 * SJL

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Otub1tm1b(EUCOMM)Hmgu/Otub1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Otub1tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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