ENSMUSG00000004231


Mus musculus

Features
Gene ID: ENSMUSG00000004231
  
Biological name :Pax2
  
Synonyms : paired box 2 / Pax2
  
Possible biological names infered from orthology : Q02962
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C3
Gene start: 44756045
Gene end: 44837871
  
Corresponding Affymetrix probe sets: 10463389 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000004340
Ensembl peptide - ENSMUSP00000134311
Ensembl peptide - ENSMUSP00000134661
NCBI entrez gene - 18504     See in Manteia.
MGI - MGI:97486
RefSeq - XM_011247161
RefSeq - XM_006526755
RefSeq - XM_006526756
RefSeq - XM_006526757
RefSeq - XM_006526758
RefSeq - NM_011037
RefSeq - XM_006526749
RefSeq - XM_006526750
RefSeq - XM_006526751
RefSeq - XM_006526752
RefSeq - XM_006526753
RefSeq - XM_006526754
RefSeq Peptide - NP_035167
swissprot - G3X8Q7
swissprot - G3UZ20
swissprot - A0A0R4J267
Ensembl - ENSMUSG00000004231
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pax2aENSDARG00000028148Danio rerio
 pax2bENSDARG00000032578Danio rerio
 PAX2ENSGALG00000005689Gallus gallus
 PAX2ENSG00000075891Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pax5 / Q02650 / Paired box protein Pax-5 / Q02548* / paired box 5*ENSMUSG0000001403070
Pax8 / Q00288 / Paired box protein Pax-8 / Q06710* / paired box 8*ENSMUSG0000002697663
Pax1 / P09084 / Paired box protein Pax-1 / P15863* / paired box 1*ENSMUSG0000003703438
Pax7 / P47239 / Paired box protein Pax-7 / P23759* / paired box 7*ENSMUSG0000002873638
Pax6 / P63015 / Paired box protein Pax-6 / P26367* / paired box 6*ENSMUSG0000002716837
Pax3 / P24610 / paired box 3 / P23760*ENSMUSG0000000487236
Pax9 / P47242 / Paired box protein Pax-9 / P55771* / paired box 9*ENSMUSG0000000149732
Pax4 / P32115 / paired box 4 / O43316*ENSMUSG0000002970628


Protein motifs (from Interpro)
Interpro ID Name
 IPR001523  Paired domain
 IPR009057  Homeobox-like domain superfamily
 IPR022130  Paired-box protein 2 C-terminal
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0035566 regulation of metanephros size IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045918 negative regulation of cytolysis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048513 animal organ development IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0072207 metanephric epithelium development IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0034451 centriolar satellite IEA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000026 abnormal inner ear morphology "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Pdgfbtm1Cbet/Pdgfbtm3.1Cbet
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pax21Neu/Pax21Neu
Genetic Background: involves: 102 * C3H

 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pax2tm1Mbu/Pax2tm2(Pax5)Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu Pax2tm2(Pax5)Mbu

Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000034 abnormal vestibule morphology "malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000044 absent organ of Corti "absence of the highly specialized epithelium in the floor of the ductus cochlearis " [J:54408]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000048 abnormal stria vascularis "anomalous structure of the layer of highly vascularized pigmented granular cells on the outer wall of the cochlear duct" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Pax2M1Bpb/Pax2+
Genetic Background: C57BL/6-Pax2M1Bpb

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Airntm1Dpb/Airn+
Genetic Background: involves: FVB/N

Allelic Composition: Pax2tm1Cjt/Pax2tm1Cjt
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

Allelic Composition: Pax2tm1Mbu/Pax2tm2(Pax5)Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu Pax2tm2(Pax5)Mbu

Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C57BL/6

Allelic Composition: Pax21Neu/Pax2+,Wt1tm1Jae/Wt1+
Genetic Background: involves: 102 * 129S4/SvJae * C57BL/6

Allelic Composition: Pax2tm1Pgr/Pax2+,Rettm1Cos/Ret+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm1.1Gdr/Pax2tm1.1Gdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krt17tm1Cou/Krt17tm1Cou
Genetic Background: B6.129S2(D2)-Krt1-17tm1Cou

Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm2(Pax5)Mbu/Pax2tm2(Pax5)Mbu
Genetic Background: C3.129P2-Pax2tm2(Pax5)Mbu

Allelic Composition: Pax2tm1Mbu/Pax2tm2(Pax5)Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu Pax2tm2(Pax5)Mbu

Allelic Composition: Pax21Neu/Pax21Neu
Genetic Background: involves: 102 * C3H

Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C57BL/6

Allelic Composition: Pax21Neu/Pax2+,Wt1tm1Jae/Wt1+
Genetic Background: involves: 102 * 129S4/SvJae * C57BL/6

Allelic Composition: Pax2M1Bpb/Pax2M1Bpb
Genetic Background: C57BL/6-Pax2M1Bpb

Allelic Composition: Pax2tm1.1Gdr/Pax2tm1.1Gdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pax2tm1Gdr/Pax2tm1.1Gdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000534 abnormal ureter morphology "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Npc1m1N/Npc1m1N
Genetic Background: involves: BALB/c * C3H/HeJ * C57BL/6J

 MP:0000536 hydroureter "distention of the ureter with urine, due to blockage from any cause" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:Cml, J:13044]
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Allelic Composition: Pax2M1Bpb/Pax2+
Genetic Background: C57BL/6-Pax2M1Bpb

Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * CD-1

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Pax21Neu/Pax21Neu
Genetic Background: involves: 102 * C3H

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000850 absent cerebellum "missing the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

Allelic Composition: Pax21Neu/Pax21Neu
Genetic Background: involves: 102 * C3H

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

Allelic Composition: Pax21Neu/Pax21Neu
Genetic Background: involves: 102 * C3H

 MP:0000899 abnormal colliculi "malformed inferior and superior colliculus" [J:50311]
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Allelic Composition: Pax21Neu/Pax21Neu
Genetic Background: involves: 102 * C3H

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Pax2tm2(Pax5)Mbu/Pax2tm2(Pax5)Mbu
Genetic Background: C3.129P2-Pax2tm2(Pax5)Mbu

Allelic Composition: Pax21Neu/Pax21Neu
Genetic Background: involves: 102 * C3H

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Airntm1Dpb/Airn+
Genetic Background: involves: FVB/N

Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pax21Neu/Pax21Neu
Genetic Background: involves: 102 * C3H

Allelic Composition: Pax2tm1.1Gdr/Pax2tm1.1Gdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001144 fused vaginal opening "condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt17tm1Cou/Krt17tm1Cou
Genetic Background: B6.129S2(D2)-Krt1-17tm1Cou

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Airntm1Dpb/Airn+
Genetic Background: involves: FVB/N

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Airntm1Dpb/Airn+
Genetic Background: involves: FVB/N

Allelic Composition: Pax2M1Bpb/Pax2+
Genetic Background: C57BL/6-Pax2M1Bpb

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp2b2wri/Atp2b2+
Genetic Background: involves: BALB/cAnN

Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

Allelic Composition: Pax2tm1Mbu/Pax2tm2(Pax5)Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu Pax2tm2(Pax5)Mbu

Allelic Composition: Pax2M1Bpb/Pax2+
Genetic Background: C57BL/6-Pax2M1Bpb

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Airntm1Dpb/Airn+
Genetic Background: involves: FVB/N

Allelic Composition: Pax2Opdc/Pax2+
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Pax21Neu/Pax21Neu
Genetic Background: involves: 102 * C3H

Allelic Composition: Pax2M1Bpb/Pax2+
Genetic Background: C57BL/6-Pax2M1Bpb

Allelic Composition: Pax2M1Bpb/Pax2+
Genetic Background: involves: C3H/HeJ * C57BL/6

 MP:0001332 abnormal optic nerve innervation "misprojection or aberrant target finding of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Krt17tm1Cou/Krt17tm1Cou
Genetic Background: B6.129S2(D2)-Krt1-17tm1Cou

 MP:0001948 vesicoureteral reflux "the retrograde flow of urine from the bladder into the ureters and kidneys" [J:77653, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * CD-1

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: MitfRorp/Mitf+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Airntm1Dpb/Airn+
Genetic Background: involves: FVB/N

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0002428 abnormal semicircular canal "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002621 delayed neural tube closure "delayed fusion of the neuroepithelial layer in early development" [J:79790, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Pax21Neu/Pax21Neu
Genetic Background: involves: 102 * C3H

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax2M1Bpb/Pax2+
Genetic Background: C57BL/6-Pax2M1Bpb

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Hmbstm3Uam/Hmbstm3Uam
Genetic Background: C57BL/6-Hmbstm3Uam

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm2(Pax5)Mbu/Pax2tm2(Pax5)Mbu
Genetic Background: C3.129P2-Pax2tm2(Pax5)Mbu

Allelic Composition: Pax2tm1Mbu/Pax2tm2(Pax5)Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu Pax2tm2(Pax5)Mbu

Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C3H

Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C57BL/6

Allelic Composition: Pax21Neu/Pax2+,Wt1tm1Jae/Wt1+
Genetic Background: involves: 102 * 129S4/SvJae * C57BL/6

Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * CD-1

 MP:0003146 absent cochlear ganglion "absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [J:36834, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm1Cjt/Pax2tm1Cjt
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0003147 absent cochlea "absence or agenesis of the cochlea" [J:23837, J:36834, J:46972, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm1Cjt/Pax2tm1Cjt
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0003148 reduced cochlear coiling "a reduction in cochlear coiling or number of turns; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns" [J:56294, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003162 reduced size of lateral semicircular canal 
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Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003164 reduced size of posterior semicircular canal 
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Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003166 reduced size of superior semicircular canal 
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Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003169 abnormal scala media morphology "any malformation or absence of the division of the spiral canal of the cochlea that contains the organ of Corti (the neuroepithelial receptor organ for hearing)" [J:23837, J:46972, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003308 abnormal cochlear sensory epithelium 
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Krt17tm1Cou/Krt17tm1Cou
Genetic Background: B6.129S2(D2)-Krt1-17tm1Cou

Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm2(Pax5)Mbu/Pax2tm2(Pax5)Mbu
Genetic Background: C3.129P2-Pax2tm2(Pax5)Mbu

Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C57BL/6

Allelic Composition: Pax2M1Bpb/Pax2+
Genetic Background: C57BL/6-Pax2M1Bpb

Allelic Composition: Pax2M1Bpb/Pax2M1Bpb
Genetic Background: C57BL/6-Pax2M1Bpb

Allelic Composition: Pax2tm1Pgr/Pax2+,Rettm1Cos/Ret+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm1Gdr/Pax2tm1Gdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003534 blind vagina "presence the female reproductive canal that ends in a sac and does not connect to internal genitalia" [ncbi:Matthew Mailman, NCBI request, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt17tm1Cou/Krt17tm1Cou
Genetic Background: B6.129S2(D2)-Krt1-17tm1Cou

 MP:0003535 absent vagina "absence of the female reproductive canal located between the uterus and the vulva" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0003557 absent vas deferens "absence of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

Allelic Composition: Pax2tm1Mbu/Pax2+,Pax8tm1(cre)Mbu/Pax8tm1(cre)Mbu
Genetic Background: involves: 129P2/OlaHsd * C3H/He * C57BL/6

 MP:0003558 absent uterus "absence of the female muscular organ of gestation" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0003575 absent oviduct "absence of the tube through which the ova pass from the ovary to the uterus" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0003584 bifid ureter "cleft of the ureter into two parts or branches" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * CD-1

 MP:0003586 ureter dilation "abnormal distention of the ureter due to accumulation of fluid" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * CD-1

 MP:0003604 single kidney 
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Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C3H

Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C57BL/6

Allelic Composition: Pax2tm1Pgr/Pax2+,Rettm1Cos/Ret+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Pax2tm2(Pax5)Mbu/Pax2tm2(Pax5)Mbu
Genetic Background: C3.129P2-Pax2tm2(Pax5)Mbu

 MP:0003626 kidney medulla hypoplasia 
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Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C57BL/6

Allelic Composition: Pax21Neu/Pax2+,Wt1tm1Jae/Wt1+
Genetic Background: involves: 102 * 129S4/SvJae * C57BL/6

 MP:0003642 absent seminal gland "absence of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003672 abnormal ureter development "anomalous differentiation of the tube that conducts the urine from the renal pelvis to the bladder" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96485]
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Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * CD-1

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C3H

Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C57BL/6

Allelic Composition: Pax2M1Bpb/Pax2+
Genetic Background: C57BL/6-Pax2M1Bpb

 MP:0003703 abnormal vestibulocochlear ganglion morphology "malformed group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pax21Neu/Pax21Neu
Genetic Background: involves: 102 * C3H

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003722 absent ureter "missing the tube that conducts the urine from the renal pelvis to the bladder" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm1Cjt/Pax2tm1Cjt
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

Allelic Composition: Pax2tm1Mbu/Pax2tm2(Pax5)Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu Pax2tm2(Pax5)Mbu

Allelic Composition: Pax2tm1Pgr/Pax2+,Rettm1Cos/Ret+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm1Mbu/Pax2+,Pax8tm1(cre)Mbu/Pax8tm1(cre)Mbu
Genetic Background: involves: 129P2/OlaHsd * C3H/He * C57BL/6

 MP:0003727 abnormal retinal layer morphology "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C3H

 MP:0003938 abnormal ear development "developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax21Neu/Pax21Neu
Genetic Background: involves: 102 * C3H

 MP:0003987 small vestibular ganglion "reduced size of the vestibular ganglion or of the sensory neuron cell bodies associated with the eighth cranial nerve" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004017 duplex kidney "a kidney that is split into two separate collecting systems; there may be a duplex ureter or a single ureter; may present unilaterally or bilaterally" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * CD-1

 MP:0004195 abnormal calyx morphology "any structural anomaly of any of the branches of the renal pelvis that surround each renal papilla and collect urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax21Neu/Pax2+,Wt1tm1Jae/Wt1+
Genetic Background: involves: 102 * 129S4/SvJae * C57BL/6

 MP:0004267 abnormal optic tract morphology "any structural anomaly of the band of optic nerve fibers running from the optic chiasma to the lateral geniculate body and midbrain" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004268 abnormal optic stalk morphology "any structural anomaly of the narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax21Neu/Pax21Neu
Genetic Background: involves: 102 * C3H

 MP:0004315 absent saccule "absence of the smaller of the two sacs in the vestibule " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0004317 small saccule "reduced size of the cavity between the semicircular canals and the cochlea of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004330 abnormal saccular macula morphology "any structural abnormalities in the oval neuroepithelial sensory receptor in the anterior wall of the saccule; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004369 absent utricle "absence of the larger of the two sacs in the vestibule" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax21Neu/Pax21Neu
Genetic Background: involves: 102 * C3H

 MP:0004425 abnormal otolith organ "any structural abnormality in the utricle and saccule of the inner ear which possess otoliths and respond to linear acceleration and deceleration, including gravity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

Allelic Composition: Pax2tm1Mbu/Pax2tm2(Pax5)Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu Pax2tm2(Pax5)Mbu

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Krt17tm1Cou/Krt17tm1Cou
Genetic Background: B6.129S2(D2)-Krt1-17tm1Cou

Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C57BL/6

Allelic Composition: Pax21Neu/Pax2+,Wt1tm1Jae/Wt1+
Genetic Background: involves: 102 * 129S4/SvJae * C57BL/6

Allelic Composition: Pax2tm1Pgr/Pax2+,Rettm1Cos/Ret+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0004717 absent cochlear nerve "absence of the part of the vestibulocochlear nerve [CN VIII] that is peripheral to the cochlear root" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004727 absent epididymis "absence of the elongated structure connected to the posterior surface of the testis, consisting of the head, body, and tail, which turns sharply on itself to become the ductus deferens (vas deferens)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0004729 absent efferent ductules of testis "absence of the small seminal ducts that lead from the testis to the head of the epididymis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004754 abnormal kidney collecting duct "any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax21Neu/Pax2+,Wt1tm1Jae/Wt1+
Genetic Background: involves: 102 * 129S4/SvJae * C57BL/6

 MP:0004922 abnormal common crus morphology "any structural abnormality in the united, nonampullary ends of the superior and posterior semicircular ducts of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C57BL/6

Allelic Composition: Pax2tm1Pgr/Pax2+,Rettm1Cos/Ret+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax21Neu/Pax2+,Tg(Hoxb7-EGFP)33Cos/?
Genetic Background: involves: 102 * C57BL/6 * CBA * CD-1

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

Allelic Composition: Pax2tm1Mbu/Pax2tm2(Pax5)Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu Pax2tm2(Pax5)Mbu

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pax2M1Bpb/Pax2+
Genetic Background: C57BL/6-Pax2M1Bpb

 MP:0005262 coloboma "anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pax21Neu/Pax21Neu
Genetic Background: involves: 102 * C3H

Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102

 MP:0006011 abnormal endolymphatic duct morphology "any structural alteration in the small membranous canal, connecting with both saccule and utricle of the membranous labyrinth, passing through the aqueduct of vestibule, and terminating in the endolymphatic sac." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006012 dilated endolymphatic duct "an expansion in the volume of the endolymphatic duct" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:67072:]
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Allelic Composition: Pax21Neu/Pax21Neu
Genetic Background: involves: 102 * C3H

 MP:0006032 abnormal ureteric bud morphology "anomaly in the formation or development of the ureteric bud that with the metanephric mesenchyme gives rise to the kidneys " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
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Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * CD-1

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C3H

 MP:0006089 abnormal saccule morphology "malformation in the smaller of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006090 abnormal utricle morphology "malformation in the larger of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006106 absent tectum "absence or loss of the rostral part of the midbrain roof" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0006303 abnormal retinal nerve fiber layer morphology "malformation of the layer of the retina formed by expansion of the fibers of the optic nerve" [ISBN:0-914294-08-3 "Gray s Anatomy", J:67382, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C3H

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C3H

 MP:0006426 Mullerian duct degeneration "a retrogressive impairment of function or destruction of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [J:30343, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0008065 short endolymphatic duct "length reduction or truncation of the small membranous canal which connects with both saccule and utricle of the membranous labyrinth, passes through the aqueduct of vestibule, and terminates in the endolymphatic sac" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008066 small endolymphatic duct "reduced size of the small membranous canal which connects with both saccule and utricle of the membranous labyrinth, passes through the aqueduct of vestibule, and terminates in the endolymphatic sac" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008259 abnormal optic disc morphology "any structural anomaly of the area in the retina where all of the axons of the ganglion cells exit the retina to form the optic nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C3H

 MP:0008307 short scala media "reduced length of the spirally arranged membranous tube suspended within the cochlea, lying between and separating the scala vestibuli and scala tympani" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008487 abnormal mesonephros morphology "any structural anomaly of the excretory organ of the embryo, collective Wolffian tubules, which forms the urogenital fold from which the reproductive organs develop" [MESH:A16.254.500]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008488 abnormal semicircular canal ampulla morphology "any structural anomaly of the spherical enlargement at the base of each semicircular canal where they connect with the utricle, containing the crista ampullaris which detects movement of the fluid within the canals" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Eya1tm1Rilm/Eya1+,Pax2tm1Pgr/Pax2+,Six1tm1Mair/Six1+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008507 thin retinal ganglion layer "reduced thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C3H

 MP:0009074 Wolffian duct degeneration "a retrogressive impairment of function or destruction of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and later develop into the ductus deferens in the male" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0009075 rudimentary Wolffian ducts "not fully developed or remnants of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and later develop into the ductus deferens in the male" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009076 rudimentary Mullerian ducts "not fully developed or remnants of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and in the female develop into the oviducts, uterus, and cranial vagina" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009113 increased pancreatic beta cell mass "greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax21Neu/Pax21Neu
Genetic Background: involves: 102 * C3H

Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102

 MP:0009167 increased pancreatic islet number "increase in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Pax21Neu/Pax21Neu
Genetic Background: involves: 102 * C3H

Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102

 MP:0009215 absent uterine horn "absence of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009262 absent semicircular canal ampulla "absence of the spherical enlargement at the base of each semicircular canal where they connect with the utricle, containing the crista ampullaris which detects movement of the fluid within the canals" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pax21Neu/Pax21Neu
Genetic Background: involves: 102 * C3H

 MP:0009771 absent optic chiasm "absence of the flattened quadrangular body that is the point of crossing of the fibers of the optic nerves" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009846 abnormal neural crest morphology 
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Allelic Composition: Pax2M1Bpb/Pax2M1Bpb
Genetic Background: C57BL/6-Pax2M1Bpb

 MP:0010097 abnormal retinal blood vessel morphology "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax2M1Bpb/Pax2+
Genetic Background: C57BL/6-Pax2M1Bpb

 MP:0010098 abnormal retinal blood vessel pattern "anomaly in the systematic arrangement of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax2M1Bpb/Pax2+
Genetic Background: C57BL/6-Pax2M1Bpb

 MP:0010118 abnormal intermediate mesoderm "any anomaly of the band of mesoderm located between the segmented paraxial mesoderm and the lateral plate mesoderm, that develops into the nephrogenic cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010716 coloboma of the optic disc "congenital defect of the optic disc in which some part of the structure is absent" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax2Opdc/Pax2+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0010717 coloboma of the optic nerve "congenital defect of the optic nerve in which some part of the structure is absent" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010978 absent ureteric bud "absence of the epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme" [PMID:19828308]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010980 ectopic ureteric bud "ureteric bud(s) are not located in the normal or expected position" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * CD-1

Allelic Composition: Pax21Neu/Pax2+,Tg(Hoxb7-EGFP)33Cos/?
Genetic Background: involves: 102 * C57BL/6 * CBA * CD-1

 MP:0010984 abnormal metanephric mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing metanephros; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:19828308]
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Allelic Composition: Krt17tm1Cou/Krt17tm1Cou
Genetic Background: B6.129S2(D2)-Krt1-17tm1Cou

Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax21Neu/Pax21Neu
Genetic Background: involves: 102 * C3H

 MP:0010986 abnormal mesonephric mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing mesonephros" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C57BL/6

Allelic Composition: Pax21Neu/Pax2+,Wt1tm1Jae/Wt1+
Genetic Background: involves: 102 * 129S4/SvJae * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Pax21Neu/Pax21Neu
Genetic Background: involves: 102 * C3H

Allelic Composition: Pax2tm1.1Gdr/Pax2tm1.1Gdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pax2tm1Gdr/Pax2tm1.1Gdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Pax2tm2(Pax5)Mbu/Pax2tm2(Pax5)Mbu
Genetic Background: C3.129P2-Pax2tm2(Pax5)Mbu

Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

Allelic Composition: Pax2M1Bpb/Pax2M1Bpb
Genetic Background: C57BL/6-Pax2M1Bpb

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C57BL/6

Allelic Composition: Pax21Neu/Pax2+,Wt1tm1Jae/Wt1+
Genetic Background: involves: 102 * 129S4/SvJae * C57BL/6

Allelic Composition: Pax2M1Bpb/Pax2M1Bpb
Genetic Background: C57BL/6-Pax2M1Bpb

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Pax2tm1Pgr/Pax2+,Rettm1Cos/Ret+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0011290 decreased nephron number "reduction in the total number of filtering units of the kidney" [MGI:anna]
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Allelic Composition: Krt17tm1Cou/Krt17tm1Cou
Genetic Background: B6.129S2(D2)-Krt1-17tm1Cou

Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C57BL/6

Allelic Composition: Pax21Neu/Pax2+,Wt1tm1Jae/Wt1+
Genetic Background: involves: 102 * 129S4/SvJae * C57BL/6

Allelic Composition: Pax2tm1Gdr/Pax2tm1Gdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011307 kidney medulla cysts "abnormal membranous sacs appearing in the inner portion of the kidney which consists of the renal pyramids" [MGI:anna]
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Allelic Composition: Pax2tm1Gdr/Pax2tm1Gdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011334 abnormal nephrogenic zone morphology "any structural anomaly in the region found at the periphery of the developing metanephros within which the metanephric mesenchyme aggregates around the tips of the ureteric tree to form the nephrons; in rodents including mice, this region normally disappears within the first postnatal week when nephrogenesis ceases and only mature nephrons are present; in humans, it is lost by 36 weeks of gestation" [PMID:17452023]
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Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C57BL/6

 MP:0011360 kidney cortex hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the outer portion of the kidney, which contains the renal corpuscles, the renal tubules (except for parts of the loop of Henle which descend into the renal medulla), blood vessels and cortical collecting ducts" [MGI:anna]
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Allelic Composition: Pax2tm1Pgr/Pax2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011365 small metanephros "reduced size of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord" [MGI:anna]
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Allelic Composition: Krt17tm1Cou/Krt17tm1Cou
Genetic Background: B6.129S2(D2)-Krt1-17tm1Cou

 MP:0011366 absent metanephros "absence of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord" [MGI:anna]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm1Mbu/Pax2+,Pax8tm1(cre)Mbu/Pax8tm1(cre)Mbu
Genetic Background: involves: 129P2/OlaHsd * C3H/He * C57BL/6

 MP:0011368 increased kidney apoptosis "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Pax2tm2(Pax5)Mbu/Pax2tm2(Pax5)Mbu
Genetic Background: C3.129P2-Pax2tm2(Pax5)Mbu

Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * C57BL/6

Allelic Composition: Pax21Neu/Pax2+,Wt1tm1Jae/Wt1+
Genetic Background: involves: 102 * 129S4/SvJae * C57BL/6

 MP:0011382 abnormal kidney lobule morphology "any structural anomaly of the portion of a renal lobe consisting of nephrons grouped around a single medullary ray and draining into a single collecting duct; human kidneys have multilobular, multipapillary architecture while mice and rats have unilobular, unipapillary kidneys" [MGI:csmith]
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Allelic Composition: Pax2tm1Gdr/Pax2tm1Gdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011493 double ureter "two ureters open separately into the renal pelvis superiorly and drain separately into the urinary bladder or genital tract; if two ureteral buds arise from the Wolffian duct, a duplex kidney with complete ureteral duplication ensues" [http://emedicine.medscape.com/article/378075-overview, MGI:anna]
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Allelic Composition: Pax2tm1Gdr/Pax2tm1Gdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pax21Neu/Pax2+
Genetic Background: involves: 102 * CD-1

 MP:0012132 abnormal midbrain-hindbrain boundary morphology "any structural anomaly of the midbrain-hindbrain domain of the embryonic brain that is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; normally, an organizing center located at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [MGI:anna]
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Allelic Composition: Pax2M1Bpb/Pax2+
Genetic Background: C57BL/6-Pax2M1Bpb

Allelic Composition: Pax2M1Bpb/Pax2M1Bpb
Genetic Background: C57BL/6-Pax2M1Bpb

 MP:0012133 absent midbrain-hindbrain boundary "absence of the midbrain-hindbrain domain of the embryonic brain that is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; normally, an organizing center located at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [MGI:anna]
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Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

Allelic Composition: Pax21Neu/Pax21Neu
Genetic Background: involves: 102 * C3H

 MP:0012533 uveal coloboma "congenital defect of the uvea in which some part of the structure is absent" [MGI:anna]
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Allelic Composition: Pax2M1Bpb/Pax2M1Bpb
Genetic Background: C57BL/6-Pax2M1Bpb

 MP:0012535 abnormal optic fissure closure "failure to initiate and/or complete closure of the transient gap in the ventral margin of the developing optic cup; fusion of the optic fissure begins with apposition of the inferior lips of the ventral-most optic cup and continues anteriorly toward its rim and posteriorly along the optic stalk; failure or late closure of the optic fissure prevents the establishment of normal fetal intraocular pressure and can result in microphthalmia associataed with colobomas" [MGI:anna]
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Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0012536 delayed optic fissure closure "late onset of the initiation and/or completion of closure of the transient gap in the ventral margin of the developing optic cup; fusion of the optic fissure begins with apposition of the inferior lips of the ventral-most optic cup and continues anteriorly toward its rim and posteriorly along the optic stalk" [MGI:anna]
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Allelic Composition: Pax2M1Bpb/Pax2M1Bpb
Genetic Background: C57BL/6-Pax2M1Bpb

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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