ENSDARG00000028148


Danio rerio

Features
Gene ID: ENSDARG00000028148
  
Biological name :pax2a
  
Synonyms : paired box 2a / pax2a / Q90268
  
Possible biological names infered from orthology : paired box 2 / PAX2 / Q02962
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 29770837
Gene end: 29805529
  
Corresponding Affymetrix probe sets: Dr.10.1.S1_at (Zebrafish Array)   Dr.10.4.S1_a_at (Zebrafish Array)   NM_131184_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000121955
Ensembl peptide - ENSDARP00000134011
Ensembl peptide - ENSDARP00000131368
Ensembl peptide - ENSDARP00000123540
Ensembl peptide - ENSDARP00000123397
Ensembl peptide - ENSDARP00000071460
Ensembl peptide - ENSDARP00000071466
Ensembl peptide - ENSDARP00000112529
Ensembl peptide - ENSDARP00000113404
Ensembl peptide - ENSDARP00000115771
Ensembl peptide - ENSDARP00000119623
Ensembl peptide - ENSDARP00000121417
NCBI entrez gene - 30425     See in Manteia.
RefSeq - NM_131184
RefSeq Peptide - NP_571259
swissprot - A0A0R4IJW2
swissprot - A0A0R4IAI2
swissprot - F1Q6N9
swissprot - F1QEK2
swissprot - F1QHP2
swissprot - F1QKT4
swissprot - F1R5S6
swissprot - F1R6E2
swissprot - Q90268
swissprot - B8JJS4
swissprot - B8JJS3
ZFIN ID - ZDB-GENE-990415-8
Ensembl - ENSDARG00000028148
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PAX2ENSGALG00000005689Gallus gallus
 PAX2ENSG00000075891Homo sapiens
 Pax2ENSMUSG00000004231Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pax2b / paired box 2b / PAX2* / Q02962* / paired box 2*ENSDARG0000003257891
pax5 / paired box 5 / Q02548* / Q02650* / Paired box protein Pax-5 *ENSDARG0000003738363
pax8 / paired box 8 / Q06710*ENSDARG0000001587959
pax6a / P26630 / paired box 6aENSDARG0000010337939
pax6b / paired box 6bENSDARG0000004593639
pax7a / paired box 7a / PAX7* / P23759* / paired box 7*ENSDARG0000010039838
pax7b / paired box 7b / PAX7* / P47239* / P23759* / paired box 7* / Paired box protein Pax-7 *ENSDARG0000007081837
pax3a / paired box 3a / PAX3* / P23760* / P24610* / paired box 3*ENSDARG0000001019236
pax1a / paired box 1a / PAX1* / P15863* / paired box 1*ENSDARG0000000820334
pax3b / paired box 3b / PAX3* / P23760* / paired box 3*ENSDARG0000002834834
pax1b / paired box 1b / PAX1* / P15863* / P09084* / paired box 1* / Paired box protein Pax-1 *ENSDARG0000007381433
pax9 / paired box 9 / P47242* / P55771* / Paired box protein Pax-9 *ENSDARG0000005382932
pax4 / paired box 4 / O43316* / P32115*ENSDARG0000002133627


Protein motifs (from Interpro)
Interpro ID Name
 IPR001523  Paired domain
 IPR009057  Homeobox-like domain superfamily
 IPR011991  ArsR-like helix-turn-helix domain
 IPR022130  Paired-box protein 2 C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001708 cell fate specification IMP
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0007422 peripheral nervous system development IMP
 biological_processGO:0009880 embryonic pattern specification IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0021549 cerebellum development IMP
 biological_processGO:0021588 cerebellum formation IMP
 biological_processGO:0021703 locus ceruleus development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030878 thyroid gland development IMP
 biological_processGO:0030901 midbrain development IMP
 biological_processGO:0030902 hindbrain development IMP
 biological_processGO:0030917 midbrain-hindbrain boundary development IMP
 biological_processGO:0034672 anterior/posterior pattern specification involved in pronephros development IGI
 biological_processGO:0035775 pronephric glomerulus morphogenesis IMP
 biological_processGO:0043049 otic placode formation IMP
 biological_processGO:0048596 embryonic camera-type eye morphogenesis IGI
 biological_processGO:0048793 pronephros development IMP
 biological_processGO:0060113 inner ear receptor cell differentiation IMP
 biological_processGO:0060118 vestibular receptor cell development IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0072114 pronephros morphogenesis IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
brain lacks all parts of type midbrain hindbrain boundary , abnormal
brain hydrocephalic , abnormal
Show

 ZFA:0000013 cranial ganglion cranial ganglion neuron decreased amount , abnormal
Show

 ZFA:0000019 epiphysis epiphysis decreased width , abnormal
Show

 ZFA:0000029 hindbrain hindbrain distended , abnormal
Show

 ZFA:0000030 macula utricle macula utricle has extra parts of type hair cell , abnormal
Show

 ZFA:0000035 lens lens decreased size , abnormal
lens opaque , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary quality , abnormal
midbrain hindbrain boundary absent , abnormal
midbrain hindbrain boundary aplastic , abnormal
midbrain hindbrain boundary ventro-medial region apoptotic , abnormal
midbrain hindbrain boundary morphology , abnormal
midbrain hindbrain boundary physical object quality , abnormal
midbrain hindbrain boundary apoptotic , abnormal
midbrain hindbrain boundary malformed , abnormal
Show

 ZFA:0000046 retinal neural layer retinal neural layer closure incomplete , abnormal
Show

 ZFA:0000047 peripheral olfactory organ peripheral olfactory organ cilium morphology , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle decreased size , abnormal
otic vesicle lacks all parts of type otolith , abnormal
otic vesicle has fewer parts of type hair cell , abnormal
otic vesicle has extra parts of type hair cell , abnormal
otic vesicle ventro-lateral region increased distribution , abnormal
otic vesicle neuroblast delamination increased occurrence , abnormal
otic vesicle neuroblast proliferation decreased occurrence , abnormal
otic vesicle physical object quality , abnormal
otic vesicle morphology , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000076 swim bladder swim bladder aplastic , abnormal
Show

 ZFA:0000100 cerebellum cerebellum absent , abnormal
cerebellum malformed , abnormal
Show

 ZFA:0000101 diencephalon diencephalon distended , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
Show

 ZFA:0000128 midbrain midbrain aplastic , abnormal
midbrain apoptotic , abnormal
midbrain spatial pattern , abnormal
midbrain increased distribution , abnormal
Show

 ZFA:0000138 otic placode otic placode physical object quality , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium closure incomplete , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct absent , abnormal
pronephric duct lacks all parts of type epithelial cell brush border, abnormal
pronephric duct central region distended , abnormal
pronephric duct epithelial cell flattened , abnormal
pronephric duct physical object quality , abnormal
Show

 ZFA:0000151 pronephros pronephros quality , abnormal
pronephros absent , abnormal
pronephros poorly differentiated , abnormal
pronephros physical object quality , abnormal
Show

 ZFA:0000320 caudal commissure caudal commissure increased size , abnormal
Show

 ZFA:0000386 macula macula has extra parts of type hair cell , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II malformed , abnormal
cranial nerve II neuron projection physical object quality , abnormal
Show

 ZFA:0000445 optic tectum optic tectum decreased size , abnormal
optic tectum morphology , abnormal
optic tectum malformed , abnormal
optic tectum aplastic , abnormal
optic tectum apoptotic , abnormal
optic tectum absent , abnormal
optic tectum cell degenerate , abnormal
optic tectum cell refractile , abnormal
Show

 ZFA:0000450 trochlear motor nucleus trochlear motor nucleus has fewer parts of type neuron , abnormal
Show

 ZFA:0000490 commissura cerebelli commissura cerebelli aplastic , abnormal
Show

 ZFA:0000539 locus coeruleus locus coeruleus absent , abnormal
Show

 ZFA:0000553 oculomotor nucleus oculomotor nucleus has fewer parts of type neuron , abnormal
Show

 ZFA:0000556 optic chiasm optic chiasm cranial nerve II ipsilateral to optic chiasm cranial nerve II, abnormal
optic chiasm absent , abnormal
optic chiasm cranial nerve II malformed , abnormal
Show

 ZFA:0000600 cranial nerve IV cranial nerve IV aplastic , abnormal
Show

 ZFA:0000618 ansulate commissure ansulate commissure decreased size , abnormal
Show

 ZFA:0000700 utricle utricle lacks parts or has fewer parts of type hair cell , abnormal
Show

 ZFA:0001072 thyroid follicle thyroid follicle aplastic , abnormal
thyroid follicle morphology , abnormal
thyroid follicle decreased distribution , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism decreased length , abnormal
whole organism lacks all parts of type otic vesicle , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved , abnormal
Show

 ZFA:0001202 optic cup optic cup physical object quality , abnormal
Show

 ZFA:0001284 optic fissure optic fissure closure incomplete , abnormal
Show

 ZFA:0001367 forebrain midbrain boundary forebrain midbrain boundary decreased distance hindbrain commissure , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0001555 epibranchial ganglion epibranchial ganglion decreased amount , abnormal
Show

 ZFA:0001557 pronephric glomerulus pronephric glomerulus aplastic , abnormal
Show

 ZFA:0001558 pronephric tubule pronephric tubule anterior region malformed , abnormal
pronephric tubule dilated , abnormal
Show

 ZFA:0001617 otolith otolith malformed , abnormal
Show

 ZFA:0005123 gut epithelium gut epithelium edematous , abnormal
Show

 ZFA:0007045 midbrain hindbrain boundary neural keel midbrain hindbrain boundary neural keel physical object quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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