ENSDARG00000045936


Danio rerio

Features
Gene ID: ENSDARG00000045936
  
Biological name :pax6b
  
Synonyms : paired box 6b / pax6b
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 15871156
Gene end: 15900606
  
Corresponding Affymetrix probe sets: Dr.5054.1.A1_at (Zebrafish Array)   Dr.5054.2.S1_at (Zebrafish Array)   Dr.8182.1.S1_at (Zebrafish Array)   NM_131641_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000143701
Ensembl peptide - ENSDARP00000152284
Ensembl peptide - ENSDARP00000143910
Ensembl peptide - ENSDARP00000019067
Ensembl peptide - ENSDARP00000115545
Ensembl peptide - ENSDARP00000136269
NCBI entrez gene - 60639     See in Manteia.
RefSeq - NM_131641
RefSeq Peptide - NP_571716
swissprot - A0A0R4IQL7
swissprot - F1QKK6
swissprot - A0A286Y952
swissprot - Q9YHZ8
ZFIN ID - ZDB-GENE-001031-1
Ensembl - ENSDARG00000045936
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pax6a / P26630 / paired box 6aENSDARG0000010337995
pax3a / paired box 3a / PAX3* / P23760* / P24610* / paired box 3*ENSDARG0000001019236
pax7a / paired box 7a / PAX7* / P23759* / paired box 7*ENSDARG0000010039836
pax7b / paired box 7b / PAX7* / P47239* / P23759* / paired box 7* / Paired box protein Pax-7 *ENSDARG0000007081836
pax2a / Q90268 / paired box 2a / PAX2* / Q02962* / paired box 2*ENSDARG0000002814834
pax2b / paired box 2b / PAX2* / Q02962* / paired box 2*ENSDARG0000003257833
pax3b / paired box 3b / PAX3* / P23760* / paired box 3*ENSDARG0000002834832
pax8 / paired box 8 / Q06710*ENSDARG0000001587930
pax5 / paired box 5 / Q02548* / Q02650* / Paired box protein Pax-5 *ENSDARG0000003738330
pax9 / paired box 9 / P47242* / P55771* / Paired box protein Pax-9 *ENSDARG0000005382926
pax1b / paired box 1b / PAX1* / P15863* / P09084* / paired box 1* / Paired box protein Pax-1 *ENSDARG0000007381425
pax1a / paired box 1a / PAX1* / P15863* / paired box 1*ENSDARG0000000820324
pax4 / paired box 4 / O43316* / P32115*ENSDARG0000002133624


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001523  Paired domain
 IPR009057  Homeobox-like domain superfamily
 IPR011991  ArsR-like helix-turn-helix domain
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development IMP
 biological_processGO:0002088 lens development in camera-type eye IMP
 biological_processGO:0002089 lens morphogenesis in camera-type eye IMP
 biological_processGO:0003309 type B pancreatic cell differentiation IMP
 biological_processGO:0003310 pancreatic A cell differentiation IMP
 biological_processGO:0003311 pancreatic D cell differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0010468 regulation of gene expression IGI
 biological_processGO:0021538 epithalamus development IGI
 biological_processGO:0030902 hindbrain development IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0061303 cornea development in camera-type eye IMP
 biological_processGO:0090104 pancreatic epsilon cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000035 lens lens decreased size , abnormal
lens morphology , abnormal
lens position , abnormal
lens vacuolated , abnormal
lens protruding , abnormal
lens quality , abnormal
lens elliptic , abnormal
lens aplastic , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000152 retina retina malformed , abnormal
Show

 ZFA:0000640 cornea cornea malformed , abnormal
cornea mislocalised , abnormal
Show

 ZFA:0001064 rhombomere rhombomere condensed , abnormal
Show

 ZFA:0001260 endocrine pancreas endocrine pancreas peptide hormone secreting cell increased amount , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0001687 corneal endothelium corneal endothelium malformed , abnormal
Show

 ZFA:0005566 anterior segment eye anterior segment eye morphology , abnormal
anterior segment eye hypoplastic , abnormal
anterior segment eye mesenchymal cell morphology , abnormal
Show

 ZFA:0009102 pancreatic B cell pancreatic B cell decreased amount , abnormal
pancreatic B cell absent , abnormal
Show

 ZFA:0009104 pancreatic A cell pancreatic A cell decreased amount , abnormal
pancreatic A cell increased amount , abnormal
Show

 ZFA:0009228 D cell D cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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