ENSMUSG00000020647


Mus musculus

Features
Gene ID: ENSMUSG00000020647
  
Biological name :Ncoa1
  
Synonyms : Ncoa1 / Nuclear receptor coactivator 1 / P70365
  
Possible biological names infered from orthology : Q15788
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: A1.1
Gene start: 4247362
Gene end: 4477182
  
Corresponding Affymetrix probe sets: 10399265 (MoGene1.0st)   1418594_a_at (Mouse Genome 430 2.0 Array)   1434515_at (Mouse Genome 430 2.0 Array)   1443397_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151358
Ensembl peptide - ENSMUSP00000151904
Ensembl peptide - ENSMUSP00000151744
Ensembl peptide - ENSMUSP00000151716
Ensembl peptide - ENSMUSP00000151610
Ensembl peptide - ENSMUSP00000151608
Ensembl peptide - ENSMUSP00000082971
Ensembl peptide - ENSMUSP00000151302
NCBI entrez gene - 17977     See in Manteia.
MGI - MGI:1276523
RefSeq - XM_011243841
RefSeq - XM_011243840
RefSeq - XM_006515005
RefSeq - XM_006515006
RefSeq - NM_010881
RefSeq - XM_006515007
RefSeq Peptide - NP_035011
swissprot - P70365
swissprot - A0A1W2P881
swissprot - A0A1W2P6K7
swissprot - A0A1W2P7C1
swissprot - A0A1W2P7D7
swissprot - A0A1W2P7S6
Ensembl - ENSMUSG00000020647
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ncoa1ENSDARG00000018257Danio rerio
 NCOA1ENSGALG00000016617Gallus gallus
 NCOA1ENSG00000084676Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ncoa2 / Q61026 / Nuclear receptor coactivator 2 / Q15596*ENSMUSG0000000588637
Ncoa3 / nuclear receptor coactivator 3 / Q9Y6Q9*ENSMUSG0000002767832


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR009110  Nuclear receptor coactivator, interlocking
 IPR010011  Domain of unknown function DUF1518
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013767  PAS fold
 IPR014920  Nuclear receptor coactivator, Ncoa-type, interlocking
 IPR014935  Nuclear receptor coactivator, receptor-binding domain
 IPR017426  Nuclear receptor coactivator
 IPR028819  Nuclear receptor coactivator 1
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily
 IPR037077  Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000435 positive regulation of transcription from RNA polymerase II promoter by galactose IMP
 biological_processGO:0002155 regulation of thyroid hormone mediated signaling pathway IGI
 biological_processGO:0006351 transcription, DNA-templated ISO
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007595 lactation IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021854 hypothalamus development IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043967 histone H4 acetylation IMP
 biological_processGO:0044849 estrous cycle IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045925 positive regulation of female receptivity IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0060179 male mating behavior IEA
 biological_processGO:0060713 labyrinthine layer morphogenesis IGI
 biological_processGO:1904017 cellular response to Thyroglobulin triiodothyronine IGI
 biological_processGO:2001038 regulation of cellular response to drug IMP
 biological_processGO:2001141 regulation of RNA biosynthetic process IMP
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0001012 RNA polymerase II regulatory region DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0004402 histone acetyltransferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0016922 nuclear receptor binding IBA
 molecular_functionGO:0017162 aryl hydrocarbon receptor binding ISO
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0030331 estrogen receptor binding ISO
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IEA
 molecular_functionGO:0033142 progesterone receptor binding IEA
 molecular_functionGO:0035257 nuclear hormone receptor binding IEA
 molecular_functionGO:0042974 retinoic acid receptor binding IEA
 molecular_functionGO:0046965 retinoid X receptor binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding ISO


Pathways (from Reactome)
Pathway description
Recycling of bile acids and salts
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Endogenous sterols
HATs acetylate histones
SUMOylation of transcription cofactors
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Tg(ZP2)2Dean/0,Tg(ZP3)7812Dean/?,Zp2tm1Dean/Zp2tm1Dean,Zp3tm1Dean/Zp3tm1Dean
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CF-1 * FVB/N

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Tg(ZP2)2Dean/0,Tg(ZP3)7812Dean/?,Zp2tm1Dean/Zp2tm1Dean,Zp3tm1Dean/Zp3tm1Dean
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CF-1 * FVB/N

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(ZP2)2Dean/0,Tg(ZP3)7812Dean/?,Zp2tm1Dean/Zp2tm1Dean,Zp3tm1Dean/Zp3tm1Dean
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CF-1 * FVB/N

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

 MP:0001940 testicular hypoplasia "decreased cell number in the testicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(ZP2)2Dean/0,Tg(ZP3)7812Dean/?,Zp2tm1Dean/Zp2tm1Dean,Zp3tm1Dean/Zp3tm1Dean
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CF-1 * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbn1tm3Rmz/Fbn1+,Fbn2tm1Rmz/Fbn2tm1Rmz
Genetic Background: involves: 129

Allelic Composition: Ncoa1tm1Hkaw/Ncoa1tm1Hkaw
Genetic Background: involves: C57BL/6J

 MP:0002774 small prostate "reduced size of the gland in males that secretes part of the seminiferous fluid" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tg(ZP2)2Dean/0,Tg(ZP3)7812Dean/?,Zp2tm1Dean/Zp2tm1Dean,Zp3tm1Dean/Zp3tm1Dean
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CF-1 * FVB/N

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tg(ZP2)2Dean/0,Tg(ZP3)7812Dean/?,Zp2tm1Dean/Zp2tm1Dean,Zp3tm1Dean/Zp3tm1Dean
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CF-1 * FVB/N

 MP:0002998 abnormal bone remodeling "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tg(ZP2)2Dean/0,Tg(ZP3)7812Dean/?,Zp2tm1Dean/Zp2tm1Dean,Zp3tm1Dean/Zp3tm1Dean
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CF-1 * FVB/N

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

Allelic Composition: Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thrbtm1Olc/Thrbtm1Olc
Genetic Background: B6.129-Ncoa1tm1Bwo Thrbtm1Olc

Allelic Composition: Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
Genetic Background: B6.129-Thratm2Jas Ncoa1tm1Bwo

 MP:0003845 abnormal decidualization "disrupted proliferation, differentiation or transformation of endometrial stromal cells into decidual cells in the maternal uterus following embryo implantation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:43609, J:48920]
Show

Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

Allelic Composition: Ncoa1tm1Bwo/Ncoa1tm1Bwo,Ncoa2tm1.1Ipc/Ncoa2tm1.1Ipc,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(ZP2)2Dean/0,Tg(ZP3)7812Dean/?,Zp2tm1Dean/Zp2tm1Dean,Zp3tm1Dean/Zp3tm1Dean
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CF-1 * FVB/N

 MP:0005119 decreased circulating thyroid-stimulating hormone level "less than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Thratm2Jas/Thratm2Jas
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005122 increased circulating thyroid-stimulating hormone level "greater than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

Allelic Composition: Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thrbtm1Olc/Thrbtm1Olc
Genetic Background: B6.129-Ncoa1tm1Bwo Thrbtm1Olc

Allelic Composition: Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
Genetic Background: B6.129-Thratm2Jas Ncoa1tm1Bwo

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mmachctm1.1(NCOM)Mfgc/Mmachctm1.1(NCOM)Mfgc
Genetic Background: C57BL/6N-Mmachctm1.1(NCOM)Mfgc/Tcp

 MP:0005182 increased circulating estradiol level "greater than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tg(ZP2)2Dean/0,Tg(ZP3)7812Dean/?,Zp2tm1Dean/Zp2tm1Dean,Zp3tm1Dean/Zp3tm1Dean
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CF-1 * FVB/N

 MP:0005468 abnormal thyroid hormone level "aberrant concentration of any of the hormones secreted by the thryoid gland" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:13923, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

 MP:0005470 increased thyroxine level "greater than the normal concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

 MP:0005474 increased triiodothyronine level "greater than the normal concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

 MP:0005477 increased circulating thyroxine level "greater than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

Allelic Composition: Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thrbtm1Olc/Thrbtm1Olc
Genetic Background: B6.129-Ncoa1tm1Bwo Thrbtm1Olc

Allelic Composition: Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
Genetic Background: B6.129-Thratm2Jas Ncoa1tm1Bwo

 MP:0005480 increased circulating triiodothyronine level "greater than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad2tm3Rob/Smad2tm3Rob
Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

Allelic Composition: Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thrbtm1Olc/Thrbtm1Olc
Genetic Background: B6.129-Ncoa1tm1Bwo Thrbtm1Olc

Allelic Composition: Ncoa1tm1Bwo/Ncoa1tm1Bwo,Thratm2Jas/Thratm2Jas
Genetic Background: B6.129-Thratm2Jas Ncoa1tm1Bwo

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Tg(ZP2)2Dean/0,Tg(ZP3)7812Dean/?,Zp2tm1Dean/Zp2tm1Dean,Zp3tm1Dean/Zp3tm1Dean
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CF-1 * FVB/N

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(ZP2)2Dean/0,Tg(ZP3)7812Dean/?,Zp2tm1Dean/Zp2tm1Dean,Zp3tm1Dean/Zp3tm1Dean
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CF-1 * FVB/N

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(ZP2)2Dean/0,Tg(ZP3)7812Dean/?,Zp2tm1Dean/Zp2tm1Dean,Zp3tm1Dean/Zp3tm1Dean
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CF-1 * FVB/N

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Mmachctm1.1(NCOM)Mfgc/Mmachctm1.1(NCOM)Mfgc
Genetic Background: C57BL/6N-Mmachctm1.1(NCOM)Mfgc/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004872 Pax3 / P24610 / paired box 3 / P23760*  / reaction / complex
 ENSMUSG00000005886 Ncoa2 / Q61026 / Nuclear receptor coactivator 2 / Q15596*  / complex / reaction
 ENSMUSG00000047638 Nr1h4 / Q60641 / Bile acid receptor / Q96RI1* / nuclear receptor subfamily 1 group H member 4*  / complex / reaction
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / complex / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000015846 Rxra / P28700 / retinoid X receptor alpha / P19793*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr