ENSG00000084676


Homo sapiens

Features
Gene ID: ENSG00000084676
  
Biological name :NCOA1
  
Synonyms : NCOA1 / nuclear receptor coactivator 1 / Q15788
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p23.3
Gene start: 24491914
Gene end: 24770702
  
Corresponding Affymetrix probe sets: 209105_at (Human Genome U133 Plus 2.0 Array)   209106_at (Human Genome U133 Plus 2.0 Array)   209107_x_at (Human Genome U133 Plus 2.0 Array)   210249_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000385195
Ensembl peptide - ENSP00000385097
Ensembl peptide - ENSP00000385216
Ensembl peptide - ENSP00000288599
Ensembl peptide - ENSP00000320940
Ensembl peptide - ENSP00000379197
NCBI entrez gene - 8648     See in Manteia.
OMIM - 602691
RefSeq - XM_017005169
RefSeq - NM_003743
RefSeq - NM_147223
RefSeq - NM_147233
RefSeq - XM_005264625
RefSeq - XM_005264626
RefSeq - XM_005264628
RefSeq - XM_017005168
RefSeq Peptide - NP_003734
RefSeq Peptide - NP_671756
RefSeq Peptide - NP_671766
swissprot - B5MCN7
swissprot - Q15788
Ensembl - ENSG00000084676
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ncoa1ENSDARG00000018257Danio rerio
 NCOA1ENSGALG00000016617Gallus gallus
 Ncoa1ENSMUSG00000020647Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NCOA2 / Q15596 / nuclear receptor coactivator 2ENSG0000014039636
NCOA3 / Q9Y6Q9 / nuclear receptor coactivator 3ENSG0000012415132


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR009110  Nuclear receptor coactivator, interlocking
 IPR010011  Domain of unknown function DUF1518
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013767  PAS fold
 IPR014920  Nuclear receptor coactivator, Ncoa-type, interlocking
 IPR014935  Nuclear receptor coactivator, receptor-binding domain
 IPR017426  Nuclear receptor coactivator
 IPR028819  Nuclear receptor coactivator 1
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily
 IPR037077  Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000435 positive regulation of transcription from RNA polymerase II promoter by galactose IDA
 biological_processGO:0002155 regulation of thyroid hormone mediated signaling pathway IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0015721 bile acid and bile salt transport TAS
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0030521 androgen receptor signaling pathway NAS
 biological_processGO:0030522 intracellular receptor signaling pathway IBA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043967 histone H4 acetylation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated NAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0060713 labyrinthine layer morphogenesis IEA
 biological_processGO:1904017 cellular response to Thyroglobulin triiodothyronine IEA
 biological_processGO:2001038 regulation of cellular response to drug IEA
 biological_processGO:2001141 regulation of RNA biosynthetic process IEA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0032991 protein-containing complex IMP
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003713 transcription coactivator activity NAS
 molecular_functionGO:0004402 histone acetyltransferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0016922 nuclear receptor binding IPI
 molecular_functionGO:0017162 aryl hydrocarbon receptor binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0030331 estrogen receptor binding IPI
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IDA
 molecular_functionGO:0035257 nuclear hormone receptor binding IDA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IPI
 molecular_functionGO:0050681 androgen receptor binding NAS


Pathways (from Reactome)
Pathway description
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Recycling of bile acids and salts
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
PPARA activates gene expression
Endogenous sterols
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
HATs acetylate histones
Transcriptional regulation of white adipocyte differentiation
SUMOylation of transcription cofactors
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian Clock
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / complex / reaction
 ENSG00000135903 PAX3 / P23760 / paired box 3  / complex / reaction
 ENSG00000012504 NR1H4 / Q96RI1 / nuclear receptor subfamily 1 group H member 4  / reaction / complex
 ENSG00000140396 NCOA2 / Q15596 / nuclear receptor coactivator 2  / reaction / complex
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex / reaction
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / complex / reaction
 ENSG00000186350 RXRA / P19793 / retinoid X receptor alpha  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr