ENSG00000124151


Homo sapiens

Features
Gene ID: ENSG00000124151
  
Biological name :NCOA3
  
Synonyms : NCOA3 / nuclear receptor coactivator 3 / Q9Y6Q9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q13.12
Gene start: 47501902
Gene end: 47656877
  
Corresponding Affymetrix probe sets: 1562439_at (Human Genome U133 Plus 2.0 Array)   207700_s_at (Human Genome U133 Plus 2.0 Array)   209060_x_at (Human Genome U133 Plus 2.0 Array)   209061_at (Human Genome U133 Plus 2.0 Array)   209062_x_at (Human Genome U133 Plus 2.0 Array)   211352_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000361065
Ensembl peptide - ENSP00000361066
Ensembl peptide - ENSP00000361073
NCBI entrez gene - 8202     See in Manteia.
OMIM - 601937
RefSeq - NM_006534
RefSeq - NM_001174087
RefSeq - NM_001174088
RefSeq - NM_181659
RefSeq Peptide - NP_001167558
RefSeq Peptide - NP_001167559
RefSeq Peptide - NP_006525
RefSeq Peptide - NP_858045
swissprot - Q9Y6Q9
Ensembl - ENSG00000124151
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ncoa3ENSDARG00000077404Danio rerio
 NCOA3ENSGALG00000004570Gallus gallus
 Ncoa3ENSMUSG00000027678Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NCOA2 / Q15596 / nuclear receptor coactivator 2ENSG0000014039643
NCOA1 / Q15788 / nuclear receptor coactivator 1ENSG0000008467633


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR009110  Nuclear receptor coactivator, interlocking
 IPR010011  Domain of unknown function DUF1518
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR011989  Armadillo-like helical
 IPR013767  PAS fold
 IPR014920  Nuclear receptor coactivator, Ncoa-type, interlocking
 IPR014935  Nuclear receptor coactivator, receptor-binding domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017426  Nuclear receptor coactivator
 IPR028818  Nuclear receptor coactivator 3
 IPR032565  Domain of unknown function DUF4927
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily
 IPR037077  Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0016573 histone acetylation IEA
 biological_processGO:0030521 androgen receptor signaling pathway NAS
 biological_processGO:0030522 intracellular receptor signaling pathway IBA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0035624 receptor transactivation TAS
 biological_processGO:0043697 cell dedifferentiation ISS
 biological_processGO:0045618 positive regulation of keratinocyte differentiation IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated NAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0071392 cellular response to estradiol stimulus IDA
 biological_processGO:1902459 positive regulation of stem cell population maintenance ISS
 biological_processGO:2000035 regulation of stem cell division ISS
 biological_processGO:2001141 regulation of RNA biosynthetic process IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0032991 protein-containing complex IMP
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0000993 RNA polymerase II core binding ISS
 molecular_functionGO:0003713 transcription coactivator activity NAS
 molecular_functionGO:0004402 histone acetyltransferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0016922 nuclear receptor binding IPI
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IBA
 molecular_functionGO:0035257 nuclear hormone receptor binding IDA
 molecular_functionGO:0046966 thyroid hormone receptor binding NAS
 molecular_functionGO:0046982 protein heterodimerization activity IMP
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IPI
 molecular_functionGO:0050681 androgen receptor binding NAS
 molecular_functionGO:0097718 disordered domain specific binding IPI


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
MAPK6/MAPK4 signaling
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000069956 MAPK6 / Q16659 / mitogen-activated protein kinase 6  / reaction
 ENSG00000175832 ETV4 / P43268 / ETS variant 4  / reaction / complex
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / reaction / complex
 ENSG00000116833 NR5A2 / O00482 / nuclear receptor subfamily 5 group A member 2  / complex
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / complex
 ENSG00000171940 O75362 / ZNF217 / zinc finger protein 217  / complex
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / complex
 ENSG00000124151 NCOA3 / Q9Y6Q9 / nuclear receptor coactivator 3  / complex / reaction
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / complex






 

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