ENSG00000175832


Homo sapiens

Features
Gene ID: ENSG00000175832
  
Biological name :ETV4
  
Synonyms : ETS variant 4 / ETV4 / P43268
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.31
Gene start: 43527844
Gene end: 43579620
  
Corresponding Affymetrix probe sets: 1554576_a_at (Human Genome U133 Plus 2.0 Array)   211603_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000466673
Ensembl peptide - ENSP00000465718
Ensembl peptide - ENSP00000468636
Ensembl peptide - ENSP00000321835
Ensembl peptide - ENSP00000377273
Ensembl peptide - ENSP00000440023
Ensembl peptide - ENSP00000441749
Ensembl peptide - ENSP00000443846
NCBI entrez gene - 2118     See in Manteia.
OMIM - 600711
RefSeq - XM_017024349
RefSeq - NM_001079675
RefSeq - NM_001261437
RefSeq - NM_001261438
RefSeq - NM_001261439
RefSeq - NM_001986
RefSeq - XM_011524514
RefSeq Peptide - NP_001073143
RefSeq Peptide - NP_001248366
RefSeq Peptide - NP_001248367
RefSeq Peptide - NP_001248368
RefSeq Peptide - NP_001977
swissprot - K7EMW0
swissprot - B7Z5F4
swissprot - P43268
Ensembl - ENSG00000175832
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 etv4ENSDARG00000018303Danio rerio
 ETV4ENSGALG00000036678Gallus gallus
 Etv4ENSMUSG00000017724Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ETV1 / P50549 / ETS variant 1ENSG0000000646855
ETV5 / P41161 / ETS variant 5ENSG0000024440552
ETS1 / P14921 / ETS proto-oncogene 1, transcription factorENSG0000013495421
ETS2 / P15036 / ETS proto-oncogene 2, transcription factorENSG0000015755720
ERG / P11308 / ERG, ETS transcription factorENSG0000015755419
FLI1 / Q01543 / Fli-1 proto-oncogene, ETS transcription factorENSG0000015170219
GABPA / Q06546 / GA binding protein transcription factor alpha subunitENSG0000015472717
ETV2 / O00321 / ETS variant 2ENSG0000010567215
FEV / Q99581 / FEV, ETS transcription factorENSG0000016349714
ELK4 / P28324 / ELK4, ETS transcription factorENSG0000015871114
ELK1 / P19419 / ELK1, ETS transcription factorENSG0000012676713
ERF / P50548 / ETS2 repressor factorENSG0000010572213
ETV3 / P41162 / ETS variant 3ENSG0000011703613
ELK3 / P41970 / ELK3, ETS transcription factorENSG0000011114513
AC010616.1ENSG0000026804112
ETV3L / Q6ZN32 / ETS variant 3 likeENSG0000025383112


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR006715  PEA3-type ETS-domain transcription factor, N-terminal
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000124151 NCOA3 / Q9Y6Q9 / nuclear receptor coactivator 3  / complex / reaction






 

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