ENSMUSG00000017724


Mus musculus

Features
Gene ID: ENSMUSG00000017724
  
Biological name :Etv4
  
Synonyms : ETS translocation variant 4 / Etv4 / P28322
  
Possible biological names infered from orthology : ETS variant 4 / P43268
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 101769742
Gene end: 101785371
  
Corresponding Affymetrix probe sets: 10391490 (MoGene1.0st)   1423232_at (Mouse Genome 430 2.0 Array)   1443381_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129261
Ensembl peptide - ENSMUSP00000017868
Ensembl peptide - ENSMUSP00000102794
NCBI entrez gene - 18612     See in Manteia.
MGI - MGI:99423
RefSeq - XM_006532462
RefSeq - NM_001316366
RefSeq - NM_008815
RefSeq - XM_006532458
RefSeq - XM_006532459
RefSeq - XM_006532460
RefSeq - XM_006532461
RefSeq - NM_001316365
RefSeq Peptide - NP_032841
RefSeq Peptide - NP_001303294
RefSeq Peptide - NP_001303295
swissprot - A2A5C3
swissprot - P28322
swissprot - A2A5C2
Ensembl - ENSMUSG00000017724
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 etv4ENSDARG00000018303Danio rerio
 ETV4ENSGALG00000036678Gallus gallus
 ETV4ENSG00000175832Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Etv1 / P41164 / ETS translocation variant 1 / P50549* / ETS variant 1*ENSMUSG0000000415154
Etv5 / Q9CXC9 / ETS translocation variant 5 / P41161* / ETS variant 5*ENSMUSG0000001308952
Ets1 / P27577 / Protein C-ets-1 / P14921* / ETS proto-oncogene 1, transcription factor*ENSMUSG0000003203521
Ets2 / P15037 / Protein C-ets-2 / P15036* / ETS proto-oncogene 2, transcription factor*ENSMUSG0000002289519
Erg / P81270 / Transcriptional regulator ERG / P11308* / ERG, ETS transcription factor*ENSMUSG0000004073219
Fli1 / P26323 / Friend leukemia integration 1 transcription factor / Q01543* / Fli-1 proto-oncogene, ETS transcription factor*ENSMUSG0000001608718
Gabpa / Q00422 / GA-binding protein alpha chain / Q06546* / GA binding protein transcription factor alpha subunit*ENSMUSG0000000897618
Etv2 / P41163 / ETS translocation variant 2 / O00321* / ETS variant 2*ENSMUSG0000000631114
Elk4 / P41158 / ETS domain-containing protein Elk-4 / P28324* / ELK4, ETS transcription factor*ENSMUSG0000002643614
Fev / Q8QZW2 / Protein FEV / Q99581* / FEV, ETS transcription factor*ENSMUSG0000005519714
Elk3 / P41971 / ETS domain-containing protein Elk-3 / P41970* / ELK3, ETS transcription factor*ENSMUSG0000000839814
Elk1 / P41969 / ETS domain-containing protein Elk-1 / P19419* / ELK1, ETS transcription factor*ENSMUSG0000000940613
Etv3 / Q8R4Z4 / ETS translocation variant 3 / P41162* / ETS variant 3*ENSMUSG0000000338213
Erf / ETS2 repressor factor / P50548*ENSMUSG0000004085713
Gm4881 / AC010616.1*ENSMUSG0000010836712


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR006715  PEA3-type ETS-domain transcription factor, N-terminal
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008045 motor neuron axon guidance IMP
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0033600 negative regulation of mammary gland epithelial cell proliferation IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IPI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048863 stem cell differentiation IMP
 biological_processGO:0060444 branching involved in mammary gland duct morphogenesis IMP
 biological_processGO:0060762 regulation of branching involved in mammary gland duct morphogenesis IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000413 polyphalangy "increased number of phalanges in any of the digits" [J:13069, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Osr2tm1Jian/Osr2tm4(Osr2*)Jian
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Kmm/Etv5+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Kmm/Etv5tm1Kmm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+,Tg(Hoxb7-Venus*)17Cos/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0000524 reduced renal tubule number "fewer loops of Henle and collecting ducts" [J:40203]
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Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Osr2tm1Jian/Osr2tm4(Osr2*)Jian
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000959 abnormal somatic sensory system morphology 
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Etv1tm2Tmj/Etv1+,Etv4tm1Arbr/Etv4+
Genetic Background: involves: 129S1/Sv

 MP:0000966 reduced sensory neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Etv1tm1Tmj/Etv1tm1Tmj,Etv4tm1Arbr/Etv4+
Genetic Background: involves: 129S1/Sv

 MP:0000988 abnormal pacinian corpuscle morphology "anomalous structure of any of the rapidly adapting mechanoreceptors found in subcutaneous tissue beneath both hairy and glabrous skin, and which normally contain an afferent nerve fiber surrounded by a capsule with multiple concentric layers" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Etv1tm2Tmj/Etv1+,Etv4tm1Arbr/Etv4+
Genetic Background: involves: 129S1/Sv

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Mapttm1(Mecp2)Jae/Mapt+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001378 abnormal ejaculation "anomalies in the ability to propulse semen from the genital ducts and the urethra to the exterior" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Kmm/Etv5+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Etv4tm1Arbr/Etv4+,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Kmm/Etv5+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Kmm/Etv5tm1Kmm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0003672 abnormal ureter development "anomalous differentiation of the tube that conducts the urine from the renal pelvis to the bladder" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96485]
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Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+,Tg(Hoxb7-Venus*)17Cos/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA/J

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0003722 absent ureter "missing the tube that conducts the urine from the renal pelvis to the bladder" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Kmm/Etv5tm1Kmm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0003881 abnormal nephron morphology "malformation of the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of henle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:71588]
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Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0004297 abnormal proprioceptive neuron morphology "any structural anomaly in the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Etv1tm1Tmj/Etv1tm1Tmj,Etv4tm1Arbr/Etv4+
Genetic Background: involves: 129S1/Sv

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Etv4tm1Arbr/Etv4tm1Arbr,Etv5tm1Hass/Etv5+
Genetic Background: involves: 129S1/Sv

 MP:0005650 abnormal limb bud morphology "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]
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Allelic Composition: Osr2tm1Jian/Osr2tm4(Osr2*)Jian
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008486 decreased muscle spindle number "reduced number of the sensory organs in muscle that are involved in the stretch reflex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Etv1tm1Tmj/Etv1tm1Tmj,Etv4tm1Arbr/Etv4+
Genetic Background: involves: 129S1/Sv

 MP:0009743 preaxial polydactyly "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]
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Allelic Composition: Osr2tm1Jian/Osr2tm4(Osr2*)Jian
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapttm1(Mecp2)Jae/Mapt+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Osr2tm1Jian/Osr2tm4(Osr2*)Jian
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Osr2tm1Jian/Osr2tm4(Osr2*)Jian
Genetic Background: involves: 129S1/Sv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027678 Ncoa3 / nuclear receptor coactivator 3 / Q9Y6Q9*  / reaction / complex






 

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