ENSMUSG00000006311


Mus musculus

Features
Gene ID: ENSMUSG00000006311
  
Biological name :Etv2
  
Synonyms : ETS translocation variant 2 / Etv2 / P41163
  
Possible biological names infered from orthology : ETS variant 2 / O00321
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 30633616
Gene end: 30635852
  
Corresponding Affymetrix probe sets: 10562064 (MoGene1.0st)   1421773_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103782
NCBI entrez gene - 14008     See in Manteia.
MGI - MGI:99253
RefSeq - XM_006539542
RefSeq - NM_007959
RefSeq - XM_006539541
RefSeq Peptide - NP_031985
swissprot - P41163
Ensembl - ENSMUSG00000006311
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 etv2ENSDARG00000053868Danio rerio
 ETV2ENSG00000105672Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fli1 / P26323 / Friend leukemia integration 1 transcription factor / Q01543* / Fli-1 proto-oncogene, ETS transcription factor*ENSMUSG0000001608726
Ets2 / P15037 / Protein C-ets-2 / P15036* / ETS proto-oncogene 2, transcription factor*ENSMUSG0000002289526
Ets1 / P27577 / Protein C-ets-1 / P14921* / ETS proto-oncogene 1, transcription factor*ENSMUSG0000003203525
Erg / P81270 / Transcriptional regulator ERG / P11308* / ERG, ETS transcription factor*ENSMUSG0000004073224
Gabpa / Q00422 / GA-binding protein alpha chain / Q06546* / GA binding protein transcription factor alpha subunit*ENSMUSG0000000897622
Etv4 / P28322 / ETS translocation variant 4 / P43268* / ETS variant 4*ENSMUSG0000001772421
Etv1 / P41164 / ETS translocation variant 1 / P50549* / ETS variant 1*ENSMUSG0000000415120
Etv5 / Q9CXC9 / ETS translocation variant 5 / P41161* / ETS variant 5*ENSMUSG0000001308920
Fev / Q8QZW2 / Protein FEV / Q99581* / FEV, ETS transcription factor*ENSMUSG0000005519718
Etv3 / Q8R4Z4 / ETS translocation variant 3 / P41162* / ETS variant 3*ENSMUSG0000000338216
Gm4881 / AC010616.1*ENSMUSG0000010836716
Erf / ETS2 repressor factor / P50548*ENSMUSG0000004085716
Elk4 / P41158 / ETS domain-containing protein Elk-4 / P28324* / ELK4, ETS transcription factor*ENSMUSG0000002643614
Elk3 / P41971 / ETS domain-containing protein Elk-3 / P41970* / ELK3, ETS transcription factor*ENSMUSG0000000839814
Elk1 / P41969 / ETS domain-containing protein Elk-1 / P19419* / ELK1, ETS transcription factor*ENSMUSG0000000940613


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001707 mesoderm formation IDA
 biological_processGO:0001824 blastocyst development IMP
 biological_processGO:0001890 placenta development IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0016055 Wnt signaling pathway IDA
 biological_processGO:0030097 hemopoiesis IDA
 biological_processGO:0030218 erythrocyte differentiation IMP
 biological_processGO:0045603 positive regulation of endothelial cell differentiation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0060803 BMP signaling pathway involved in mesodermal cell fate specification IDA
 biological_processGO:2000382 positive regulation of mesoderm development IDA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000215 absent erythrocytes "lack of mature red blood cells" [J:23061]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000216 absent erythrocyte precursors "lack of progenitors of the erythrocyte lineage" [J:23061]
Show

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd
Genetic Background: B6NHsd.Cg-Dock2m1Hsd Cmahtm1Avrk

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mpzm1Anu/?
Genetic Background: involves: BALB/c * C57BL/6 * DBA/2

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd
Genetic Background: B6NHsd.Cg-Dock2m1Hsd Cmahtm1Avrk

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0001602 impaired myelopoiesis "atypical process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells with the result of fewer of these cells being formed" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptger3tm1Sna/Ptger3tm1Sna
Genetic Background: involves: 129P2/OlaHsd

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Ptger3tm1Sna/Ptger3tm1Sna
Genetic Background: involves: 129P2/OlaHsd

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Ptger3tm1Sna/Ptger3tm1Sna
Genetic Background: involves: 129P2/OlaHsd

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Ptger3tm1Sna/Ptger3tm1Sna
Genetic Background: involves: 129P2/OlaHsd

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
Show

Allelic Composition: Ptger3tm1Sna/Ptger3tm1Sna
Genetic Background: involves: 129P2/OlaHsd

 MP:0001721 absent blood islands "missing pools of blood in the yolk sac" [J:12623]
Show

Allelic Composition: Ptger3tm1Sna/Ptger3tm1Sna
Genetic Background: involves: 129P2/OlaHsd

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Ptger3tm1Sna/Ptger3tm1Sna
Genetic Background: involves: 129P2/OlaHsd

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd
Genetic Background: B6NHsd.Cg-Dock2m1Hsd Cmahtm1Avrk

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv2tm1Dlim/Etv2tm2.1Dlim,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002414 abnormal myeloblast morphology/development "anomalous structure, formation, or numbers of the cells found in the bone marrow that give rise to the granulocyte line of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Mpzm1Anu/?
Genetic Background: involves: BALB/c * C57BL/6 * DBA/2

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd
Genetic Background: B6NHsd.Cg-Dock2m1Hsd Cmahtm1Avrk

Allelic Composition: Etv2tm1Dlim/Etv2tm1Dlim
Genetic Background: involves: C57BL/6

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004086 absent heartbeat "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [J:69362, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd
Genetic Background: B6NHsd.Cg-Dock2m1Hsd Cmahtm1Avrk

 MP:0004229 abnormal embryonic erythropoiesis "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv2tm1Dlim/Etv2tm1Dlim
Genetic Background: involves: C57BL/6

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd
Genetic Background: B6NHsd.Cg-Dock2m1Hsd Cmahtm1Avrk

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

Allelic Composition: Etv2tm1Dlim/Etv2tm2.1Dlim,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0006057 decreased vascular endothelial cell number "less than normal number of cells lining the vasculature" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mpzm1Anu/?
Genetic Background: involves: BALB/c * C57BL/6 * DBA/2

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv2tm1Dlim/Etv2tm1Dlim
Genetic Background: involves: C57BL/6

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv2tm1Dlim/Etv2tm2.1Dlim,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cmahtm1Avrk/Cmahtm1Avrk,Dock2m1Hsd/Dock2m1Hsd
Genetic Background: B6NHsd.Cg-Dock2m1Hsd Cmahtm1Avrk

Allelic Composition: Etv2tm1Dlim/Etv2tm1Dlim
Genetic Background: involves: C57BL/6

Allelic Composition: Etv2tm1Vkou/Etv2tm1Vkou,Tg(Pgk1-cre)1Lni/0
Genetic Background: involves: BALB/c * C57BL/6

 MP:0011182 decreased hematopoietic cell number "fewer than expected number of cells of the hematopoietic lineage" [MGI:csmith]
Show

Allelic Composition: Mpzm1Anu/?
Genetic Background: involves: BALB/c * C57BL/6 * DBA/2

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Etv2tm1Dlim/Etv2tm1Dlim
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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