ENSMUSG00000022895


Mus musculus

Features
Gene ID: ENSMUSG00000022895
  
Biological name :Ets2
  
Synonyms : Ets2 / P15037 / Protein C-ets-2
  
Possible biological names infered from orthology : ETS proto-oncogene 2, transcription factor / P15036
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: C4
Gene start: 95702075
Gene end: 95721051
  
Corresponding Affymetrix probe sets: 10437160 (MoGene1.0st)   1416268_at (Mouse Genome 430 2.0 Array)   1437809_x_at (Mouse Genome 430 2.0 Array)   1447685_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116638
Ensembl peptide - ENSMUSP00000023612
NCBI entrez gene - 23872     See in Manteia.
MGI - MGI:95456
RefSeq - NM_011809
RefSeq Peptide - NP_035939
swissprot - D3Z4F9
swissprot - P15037
swissprot - Q3UP99
Ensembl - ENSMUSG00000022895
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ETS2ENSG00000157557Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ets1 / P27577 / Protein C-ets-1 / P14921* / ETS proto-oncogene 1, transcription factor*ENSMUSG0000003203550
Erg / P81270 / Transcriptional regulator ERG / P11308* / ERG, ETS transcription factor*ENSMUSG0000004073228
Gabpa / Q00422 / GA-binding protein alpha chain / Q06546* / GA binding protein transcription factor alpha subunit*ENSMUSG0000000897627
Fli1 / P26323 / Friend leukemia integration 1 transcription factor / Q01543* / Fli-1 proto-oncogene, ETS transcription factor*ENSMUSG0000001608726
Etv1 / P41164 / ETS translocation variant 1 / P50549* / ETS variant 1*ENSMUSG0000000415122
Etv4 / P28322 / ETS translocation variant 4 / P43268* / ETS variant 4*ENSMUSG0000001772420
Etv5 / Q9CXC9 / ETS translocation variant 5 / P41161* / ETS variant 5*ENSMUSG0000001308920
Etv2 / P41163 / ETS translocation variant 2 / O00321* / ETS variant 2*ENSMUSG0000000631118
Fev / Q8QZW2 / Protein FEV / Q99581* / FEV, ETS transcription factor*ENSMUSG0000005519716
Gm4881 / AC010616.1*ENSMUSG0000010836714
Erf / ETS2 repressor factor / P50548*ENSMUSG0000004085713
Etv3 / Q8R4Z4 / ETS translocation variant 3 / P41162* / ETS variant 3*ENSMUSG0000000338213
Elk1 / P41969 / ETS domain-containing protein Elk-1 / P19419* / ELK1, ETS transcription factor*ENSMUSG0000000940612
Elk3 / P41971 / ETS domain-containing protein Elk-3 / P41970* / ELK3, ETS transcription factor*ENSMUSG0000000839812
Elk4 / P41158 / ETS domain-containing protein Elk-4 / P28324* / ELK4, ETS transcription factor*ENSMUSG0000002643611


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR003118  Pointed domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR016311  Transforming protein C-ets
 IPR027276  Transforming protein C-ets-2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001712 ectodermal cell fate commitment IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0007498 mesoderm development IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0090009 primitive streak formation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0035259 glucocorticoid receptor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Oncogene Induced Senescence


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0000399 increased curvature of guard hairs "greater bending arch of the guard hairs" [J:47620]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0000401 increased curvature of awl hairs "greater bending arch of the awl hairs" [J:47620]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0000403 increased curvature of zigzag hairs "greater bending arch of the zigzag hairs" [J:47620]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0000406 increased curvature of auchene hairs "greater bending arch of the auchene hairs" [J:47620]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0000410 waved hair "hair or fur having undulations or a sinusoidal shape" [J:47620]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Ets2tm5.1Rgo/Ets2tm5.1Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0000630 mammary gland hyperplasia "increased size of mammary gland due to increased cell number" [J:63229]
Show

Allelic Composition: Abcc6tm1Aabb/Abcc6tm1Aabb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001274 curly vibrissae "whiskers twisted into coils or spirals" [J:47620]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Ets2tm3Rgo/Ets2tm3Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Ets2tm3Rgo/Ets2tm3Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
Show

Allelic Composition: Ets2tm2Rgo/Ets2tm2Rgo
Genetic Background: involves: FVB/N

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kat8tm2Thl/Kat8+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Ets2m1Mhda/Ets2+
Genetic Background: C3HeB/FeJ-Ets2m1Mhda

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Rhotm1Jlem/Rhotm1Jlem
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ets2tm2Rgo/Ets2tm2Rgo
Genetic Background: involves: FVB/N

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp7aMo-3Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-3Btlr

 MP:0004938 dilated vasculature "stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Ets2tm3Rgo/Ets2tm3Rgo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005032 abnormal ectoplacental cone 
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

 MP:0010269 decreased mammary gland tumor incidence "less than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp7aMo-3Btlr/Y
Genetic Background: C57BL/6J-Atp7aMo-3Btlr

Allelic Composition: Ets2tm1Rgo/Ets2tm5.1Rgo,Tg(MMTV-PyVT)634Mul/0,Tg(S100a4-cre)1Gle/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abcc6tm1Aabb/Abcc6tm1Aabb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ets2tm3Rgo/Ets2+,Meox2tm1(cre)Sor/?,Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Ets2tm3Rgo/Ets2tm3Rgo,Meox2tm1(cre)Sor/?,Tg(MMTV-cre)7Mul/?
Genetic Background: involves: 129S4/SvJaeSor * FVB/N

Allelic Composition: Ets2tm3Rgo/Ets2+,Meox2tm1(cre)Sor/?,Tg(MMTV-cre)7Mul/?
Genetic Background: involves: 129S4/SvJaeSor * FVB/N

Allelic Composition: Ets2tm1Rgo/Ets2tm5.1Rgo,Ptentm1.1Mwst/Ptentm1.1Mwst,Tg(S100a4-cre)1Gle/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ets2tm3Rgo/Ets2tm3Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: either: 129P2/OlaHsd or (involves: 129P2/OlaHsd * C57BL/6)

Allelic Composition: Ets2tm3Rgo/Ets2tm3Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

Allelic Composition: Ets2tm5.2Rgo/Ets2tm5.2Rgo
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ets2tm2Rgo/Ets2tm2Rgo
Genetic Background: involves: FVB/N

Allelic Composition: Ets2tm2Rgo/Ets2tm5.2Rgo
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

 MP:0020321 increased vascular endothelial cell apoptosis "increase in the timing or the number of vascular endothelial cells undergoing programmed cell death" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000042745 Id1 / P20067 / inhibitor of DNA binding 1 / P41134* / inhibitor of DNA binding 1, HLH protein*  / reaction / complex
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction






 

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