ENSMUSG00000042745


Mus musculus

Features
Gene ID: ENSMUSG00000042745
  
Biological name :Id1
  
Synonyms : Id1 / inhibitor of DNA binding 1 / P20067
  
Possible biological names infered from orthology : inhibitor of DNA binding 1, HLH protein / P41134
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H1
Gene start: 152736251
Gene end: 152737410
  
Corresponding Affymetrix probe sets: 10477169 (MoGene1.0st)   1425895_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000092019
Ensembl peptide - ENSMUSP00000105449
NCBI entrez gene - 15901     See in Manteia.
MGI - MGI:96396
RefSeq - XM_006498791
RefSeq - NM_001355113
RefSeq - NM_010495
RefSeq Peptide - NP_001342042
RefSeq Peptide - NP_034625
swissprot - P20067
swissprot - Q6GTZ3
swissprot - A2AHY3
Ensembl - ENSMUSG00000042745
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 id1ENSDARG00000040764Danio rerio
 ID1ENSGALG00000034661Gallus gallus
 ID1ENSG00000125968Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Id2 / P41136 / DNA-binding protein inhibitor ID-2 / Q02363* / inhibitor of DNA binding 2*ENSMUSG0000002064438
Id3 / P41133 / DNA-binding protein inhibitor ID-3 / Q02535* / inhibitor of DNA binding 3, HLH protein*ENSMUSG0000000787232
Id4 / P41139 / DNA-binding protein inhibitor ID-4 / P47928* / inhibitor of DNA binding 4, HLH protein*ENSMUSG0000002137932


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR026052  DNA-binding protein inhibitor
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001886 endothelial cell morphogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007507 heart development IGI
 biological_processGO:0007623 circadian rhythm IEP
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030509 BMP signaling pathway IDA
 biological_processGO:0031648 protein destabilization IGI
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032233 positive regulation of actin filament bundle assembly IEA
 biological_processGO:0032963 collagen metabolic process IMP
 biological_processGO:0036164 cell-abiotic substrate adhesion IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043392 negative regulation of DNA binding IDA
 biological_processGO:0043408 regulation of MAPK cascade IMP
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0045602 negative regulation of endothelial cell differentiation IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IGI
 biological_processGO:0045765 regulation of angiogenesis IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0046677 response to antibiotic IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0050774 negative regulation of dendrite morphogenesis IEA
 biological_processGO:0060425 lung morphogenesis IMP
 biological_processGO:0060426 lung vasculature development IMP
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0090074 negative regulation of protein homodimerization activity IDA
 biological_processGO:1901342 regulation of vasculature development IEA
 biological_processGO:1901653 cellular response to peptide IEA
 biological_processGO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding IEA
 biological_processGO:1903351 cellular response to dopamine IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005813 centrosome IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043621 protein self-association IDA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0070628 proteasome binding IEA


Pathways (from Reactome)
Pathway description
Oncogene Induced Senescence


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000061 fragile skeleton "easily damaged or broken bones" [J:14208]
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Allelic Composition: Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000081 premature suture closure "early fusion of the bones of the skull" [J:26513]
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Allelic Composition: Id1tm1Zhu/Id1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor

Allelic Composition: Id1tm1Zhu/Id1+,Id3tm1Zhu/Id3+,Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0000873 thin external granule cell layer "reduced thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Nlrc4tm1Vmd/Nlrc4tm1Vmd,Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: C57BL/6-Nlrp3tm1Vmd Nlrc4tm1Vmd

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Gfra2tm1Jmi/Gfra2tm1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Id1tm1Zhu/Id1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Nlrc4tm1Vmd/Nlrc4tm1Vmd,Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: C57BL/6-Nlrp3tm1Vmd Nlrc4tm1Vmd

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002984 retina hypoplasia "less than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80994]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gfra2tm1Jmi/Gfra2tm1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Nlrc4tm1Vmd/Nlrc4tm1Vmd,Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: C57BL/6-Nlrp3tm1Vmd Nlrc4tm1Vmd

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003424 premature neuronal precursor differentiation "earlier than normal transformation of neuronal precursor cells into neurons" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+,Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Id1tm1Zhu/Id1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lckm1Btlr/Lckm1Btlr
Genetic Background: C57BL/6J-Lckm1Btlr

Allelic Composition: Id1tm1Zhu/Id1tm1Zhu
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004991 decreased bone strength "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Id1tm1Zhu/Id1tm1Zhu
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0006050 pulmonary fibrosis "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gfra2tm1Jmi/Gfra2tm1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008071 absent B cells "absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0008475 intermingled spleen red and white pulp "no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009429 decreased embryo weight "reduced weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0009543 abnormal thymus corticomedullary boundary morphology "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0009772 abnormal retinal development "anomaly in any of the steps during embryogenesis that produce the nerve layer lining in the back of the eye which senses light, and creates impulses that travel through the optic nerve to the brain" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010537 tumor regression "a decrease in tumor size from a formerly larger state and/or a decrease in the extent of tumors in the body" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Id1tm1Zhu/Id1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0011140 decreased lung endothelial cell proliferation "reduced ability of an endothelial cell in the pulmonary vasculature to undergo expansion by cell division" [MGI:csmith]
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Allelic Composition: Gfra2tm1Jmi/Gfra2tm1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011141 increased lung endothelial cell apoptosis "acceleration in the timing or in the number of endothelial cells in the pulmonary vasculature to undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Gfra2tm1Jmi/Gfra2tm1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0020321 increased vascular endothelial cell apoptosis "increase in the timing or the number of vascular endothelial cells undergoing programmed cell death" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Gfra2tm1Jmi/Gfra2tm1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022895 Ets2 / P15037 / Protein C-ets-2 / P15036* / ETS proto-oncogene 2, transcription factor*  / reaction / complex






 

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