ENSMUSG00000020644


Mus musculus

Features
Gene ID: ENSMUSG00000020644
  
Biological name :Id2
  
Synonyms : DNA-binding protein inhibitor ID-2 / Id2 / P41136
  
Possible biological names infered from orthology : inhibitor of DNA binding 2 / Q02363
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: A1.3
Gene start: 25093799
Gene end: 25097140
  
Corresponding Affymetrix probe sets: 10399691 (MoGene1.0st)   1422537_a_at (Mouse Genome 430 2.0 Array)   1435176_a_at (Mouse Genome 430 2.0 Array)   1453596_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152069
Ensembl peptide - ENSMUSP00000020974
Ensembl peptide - ENSMUSP00000152052
NCBI entrez gene - 15902     See in Manteia.
MGI - MGI:96397
RefSeq - NM_010496
RefSeq Peptide - NP_034626
swissprot - A0A1Y7VMT3
swissprot - P41136
swissprot - Q545T4
Ensembl - ENSMUSG00000020644
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 id2aENSDARG00000055283Danio rerio
 id2bENSDARG00000029544Danio rerio
 ID2ENSGALG00000035016Gallus gallus
 ID2ENSG00000115738Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Id4 / P41139 / DNA-binding protein inhibitor ID-4 / P47928* / inhibitor of DNA binding 4, HLH protein*ENSMUSG0000002137943
Id1 / P20067 / inhibitor of DNA binding 1 / P41134* / inhibitor of DNA binding 1, HLH protein*ENSMUSG0000004274542
Id3 / P41133 / DNA-binding protein inhibitor ID-3 / Q02535* / inhibitor of DNA binding 3, HLH protein*ENSMUSG0000000787237


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR026052  DNA-binding protein inhibitor
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0001656 metanephros development IMP
 biological_processGO:0001779 natural killer cell differentiation IMP
 biological_processGO:0001966 thigmotaxis IMP
 biological_processGO:0002521 leukocyte differentiation IMP
 biological_processGO:0003149 membranous septum morphogenesis IMP
 biological_processGO:0003166 bundle of His development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007507 heart development IGI
 biological_processGO:0007623 circadian rhythm IEP
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0009649 entrainment of circadian clock IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0014003 oligodendrocyte development IMP
 biological_processGO:0019216 regulation of lipid metabolic process IMP
 biological_processGO:0021772 olfactory bulb development IMP
 biological_processGO:0032922 circadian regulation of gene expression IMP
 biological_processGO:0033598 mammary gland epithelial cell proliferation IMP
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0043153 entrainment of circadian clock by photoperiod IMP
 biological_processGO:0043353 enucleate erythrocyte differentiation IGI
 biological_processGO:0043392 negative regulation of DNA binding IDA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0045475 locomotor rhythm IMP
 biological_processGO:0045578 negative regulation of B cell differentiation IMP
 biological_processGO:0045600 positive regulation of fat cell differentiation IMP
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IMP
 biological_processGO:0045651 positive regulation of macrophage differentiation IGI
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 biological_processGO:0045668 negative regulation of osteoblast differentiation IGI
 biological_processGO:0045777 positive regulation of blood pressure IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0048468 cell development IGI
 biological_processGO:0048469 cell maturation IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048535 lymph node development TAS
 biological_processGO:0048541 Peyer"s patch development IGI
 biological_processGO:0048557 embryonic digestive tract morphogenesis IDA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IMP
 biological_processGO:0048663 neuron fate commitment IMP
 biological_processGO:0048667 cell morphogenesis involved in neuron differentiation IMP
 biological_processGO:0048711 positive regulation of astrocyte differentiation IMP
 biological_processGO:0048715 negative regulation of oligodendrocyte differentiation IMP
 biological_processGO:0060612 adipose tissue development IMP
 biological_processGO:0060749 mammary gland alveolus development IMP
 biological_processGO:0061030 epithelial cell differentiation involved in mammary gland alveolus development IMP
 biological_processGO:0061031 endodermal digestive tract morphogenesis IEP
 biological_processGO:0071158 positive regulation of cell cycle arrest IMP
 biological_processGO:0071285 cellular response to lithium ion IDA
 biological_processGO:0090398 cellular senescence IMP
 biological_processGO:2000045 regulation of G1/S transition of mitotic cell cycle ISO
 biological_processGO:2000178 negative regulation of neural precursor cell proliferation IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0044325 ion channel binding ISO
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0000526 small inner medullary pyramid "reduced size of pyramidal masses; contain part of the secreting tubules and collecting tubules" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0000630 mammary gland hyperplasia "increased size of mammary gland due to increased cell number" [J:63229]
Show

Allelic Composition: Cftrtm1Hgu/Cftrtm1Hgu
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Id2tm1Yyk/Id2+,Tg(Wnt1)1Hev/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr2tm1Ewj/Fgfr2+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Tg(Wnt1)1Hev/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL

Allelic Composition: Id2tm1Yyk/Id2+,Tg(Wnt1)1Hev/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
Show

Allelic Composition: Adarb1tm1.1Eme/Adarb1tm1.1Eme
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000873 thin external granule cell layer "reduced thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Nlrc4tm1Vmd/Nlrc4tm1Vmd,Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: C57BL/6-Nlrp3tm1Vmd Nlrc4tm1Vmd

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Id2tm1Mais/Id2tm1Mais
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Fgfr2tm1Ewj/Fgfr2+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Id2tm1Ago/Id2tm1Ago
Genetic Background: B6.129-Id2tm1Ago

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Id2tm1Mais/Id2tm1Mais
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr2tm1Ewj/Fgfr2+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Id2tm1Ago/Id2tm1Ago
Genetic Background: B6.129-Id2tm1Ago

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lmx1adr-sst/Lmx1adr-sst
Genetic Background: involves: BALB/cCf * C57BL/6J * DBA/2J

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Id2tm1Ago/Id2tm1Ago
Genetic Background: B6.129-Id2tm1Ago

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
Show

Allelic Composition: Fgfr2tm1Ewj/Fgfr2+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Id2tm1Mais/Id2tm1Mais
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001984 abnormal olfaction "change in the ability to smell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Adarb1tm1.1Eme/Adarb1tm1.1Eme
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Nlrc4tm1Vmd/Nlrc4tm1Vmd,Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: C57BL/6-Nlrp3tm1Vmd Nlrc4tm1Vmd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Sftpctm1.1(cre/ERT2)Ptch/Sftpc+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Tcf3tm1Cmu/Tcf3+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002219 decreased lymph node number "fewer than the normal number of lymph nodes " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgfr2tm1Ewj/Fgfr2+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Batf3tm1Kmm/Batf3tm1Kmm,Id2tm1Gtbz/Id2tm1Gtbz
Genetic Background: B6.Cg-Batf3tm1Kmm Id2tm1Gtbz

 MP:0002378 abnormal gut-associated lymphoid tissue morphology "anomalous structure or development of the regional immune system located in the gut" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Rorctm2Litt/Rorc+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002379 abnormal oropharyngeal lymphoid tissue morphology "anomalous structure or development of the circular lymphoid tissue formed by the lingual, pharyngeal, and faucial tonsils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgfr2tm1Ewj/Fgfr2+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Batf3tm1Kmm/Batf3tm1Kmm,Id2tm1Gtbz/Id2tm1Gtbz
Genetic Background: B6.Cg-Batf3tm1Kmm Id2tm1Gtbz

 MP:0002450 abnormal lymph organ development "anomaly in the process of morphological maturation of the organs of the lymph system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc4a1tm1Phsl/Slc4a1+
Genetic Background: involves: 129 * 129S6/SvEvTac * Black Swiss

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
Show

Allelic Composition: Adarb1tm1.1Eme/Adarb1tm1.1Eme
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002831 absent Peyer s patches "lymphoid tissue missing from the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fgfr2tm1Ewj/Fgfr2+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * FVB/NJ)

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Nlrc4tm1Vmd/Nlrc4tm1Vmd,Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: C57BL/6-Nlrp3tm1Vmd Nlrc4tm1Vmd

 MP:0003244 loss of dopaminergic neurons "loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Adarb1tm1.1Eme/Adarb1tm1.1Eme
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003424 premature neuronal precursor differentiation "earlier than normal transformation of neuronal precursor cells into neurons" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
Show

Allelic Composition: Adarb1tm1.1Eme/Adarb1tm1.1Eme
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+,Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003622 incomplete emptying of bladder "upon urination, some urine is retained in the bladder instead of being excreted" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Id2tm1Mais/Id2tm1Mais
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adarb1tm1.1Eme/Adarb1tm1.1Eme
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adarb1tm1.1Eme/Adarb1tm1.1Eme
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Id2tm1Ago/Id2tm1Ago
Genetic Background: B6.129-Id2tm1Ago

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0008024 absent lymph nodes "absence of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue; these are the sites where acquired immune responses are launched" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * FVB/NJ)

Allelic Composition: Id2tm1Ago/Id2tm1Ago
Genetic Background: B6.129-Id2tm1Ago

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * FVB/NJ)

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Tcf3tm1Cmu/Tcf3+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Fgfr2tm1Ewj/Fgfr2+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0008046 absent NK cells "absence of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Id2tm1Ago/Id2tm1Ago
Genetic Background: B6.129-Id2tm1Ago

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Id2tm1Ago/Id2tm1Ago
Genetic Background: B6.129-Id2tm1Ago

 MP:0008249 abnormal common lymphocyte progenitor cell morphology "any structural anomaly of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * FVB/NJ)

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Id2tm1Mais/Id2tm1Mais
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Id2tm1Mais/Id2tm1Mais
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0009293 decreased inguinal fat pad weight 
Show

Allelic Composition: Id2tm1Ago/Id2tm1Ago
Genetic Background: B6.129-Id2tm1Ago

 MP:0009295 decreased interscapular fat pad weight 
Show

Allelic Composition: Id2tm1Ago/Id2tm1Ago
Genetic Background: B6.129-Id2tm1Ago

 MP:0009485 distended ileum "an expansion in the volume of the portion of the small intestine that extends from the jejunum to the colon, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr2tm1Ewj/Fgfr2+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0009622 absent inguinal lymph nodes "absence of the lymph nodes normally located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Tcf3tm1Cmu/Tcf3+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0009628 absent brachial lymph nodes "absence of the lymph nodes located along the brachial vein that receive drainage from most of the free upper limb and send efferent vessels to the central axillary lymph nodes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Tcf3tm1Cmu/Tcf3+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0009630 absent axillary lymph nodes "absence of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Tcf3tm1Cmu/Tcf3+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk,Tg(Wnt1)1Hev/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL

Allelic Composition: Id2tm1Yyk/Id2+,Tg(Wnt1)1Hev/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Id2tm1Ago/Id2tm1Ago
Genetic Background: B6.129-Id2tm1Ago

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Fgfr2tm1Ewj/Fgfr2+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
Show

Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0011487 abnormal ureteropelvic junction morphology "any structural anomaly of the junction between the ureter and the renal pelvis of the kidney" [MGI:anna, MGI:csmith]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0011490 ureteropelvic junction stenosis "a constriction or narrowing of the junction between the ureter and the renal pelvis" [MGI:anna]
Show

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0011503 disdended jejunum "an expansion in the volume of the portion of the small intestine that extends from the duodenum to the ileum" [MGI:anna]
Show

Allelic Composition: Fgfr2tm1Ewj/Fgfr2+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Id2tm1Yyk/Id2tm1Yyk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0020472 arrhythmic circadian behavior persistence "loss of a behavioral rhythmic pattern upon removal of time cues" [MGI:smb]
Show

Allelic Composition: Id2tm1Mais/Id2tm1Mais
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0020473 abnormal circadian behavior phase "anomaly in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
Show

Allelic Composition: Id2tm1Mais/Id2tm1Mais
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr