ENSMUSG00000007872


Mus musculus

Features
Gene ID: ENSMUSG00000007872
  
Biological name :Id3
  
Synonyms : DNA-binding protein inhibitor ID-3 / Id3 / P41133
  
Possible biological names infered from orthology : inhibitor of DNA binding 3, HLH protein / Q02535
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 136143497
Gene end: 136145755
  
Corresponding Affymetrix probe sets: 10509163 (MoGene1.0st)   1416630_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000008016
NCBI entrez gene - 15903     See in Manteia.
MGI - MGI:96398
RefSeq - NM_008321
RefSeq Peptide - NP_032347
swissprot - P41133
swissprot - Q545W1
Ensembl - ENSMUSG00000007872
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 id3ENSDARG00000054823Danio rerio
 ID3ENSGALG00000035317Gallus gallus
 ID3ENSG00000117318Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Id4 / P41139 / DNA-binding protein inhibitor ID-4 / P47928* / inhibitor of DNA binding 4, HLH protein*ENSMUSG0000002137945
Id2 / P41136 / DNA-binding protein inhibitor ID-2 / Q02363* / inhibitor of DNA binding 2*ENSMUSG0000002064442
Id1 / P20067 / inhibitor of DNA binding 1 / P41134* / inhibitor of DNA binding 1, HLH protein*ENSMUSG0000004274540


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR026052  DNA-binding protein inhibitor
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0001656 metanephros development IEP
 biological_processGO:0006275 regulation of DNA replication IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007417 central nervous system development IEP
 biological_processGO:0007507 heart development IGI
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0007623 circadian rhythm IEP
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0010629 negative regulation of gene expression IDA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030855 epithelial cell differentiation IDA
 biological_processGO:0030903 notochord development IEP
 biological_processGO:0042476 odontogenesis IEP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0045662 negative regulation of myoblast differentiation IMP
 biological_processGO:0045668 negative regulation of osteoblast differentiation IGI
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0072750 cellular response to leptomycin B IDA
 cellular_componentGO:0005634 nucleus IMP
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0019904 protein domain specific binding IDA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:1901707 leptomycin B binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000081 premature suture closure "early fusion of the bones of the skull" [J:26513]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Twist1tm1Bhr/Twist1+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0000623 reduced salivation "decrease flow, secretion, or amount of saliva" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Id3tm2.1Zhu/Id3tm2.1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J

Allelic Composition: Id3tm1Zhu/Id3tm1Zhu
Genetic Background: B6.129S4-Id3tm1Zhu

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Jag1Yo/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Yo

Allelic Composition: Id3tm2.1Cmu/Id3tm2.1Cmu,Tcf3tm4Zhu/Tcf3tm4Zhu,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * DBA/2

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0000873 thin external granule cell layer "reduced thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Nlrc4tm1Vmd/Nlrc4tm1Vmd,Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: C57BL/6-Nlrp3tm1Vmd Nlrc4tm1Vmd

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0001346 abnormal lacrimal gland morphology "malformation of the glands that secrete tears" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp5tm1Jfh/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Id3tm1Zhu/Id3tm1Zhu
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Id3tm2.1Zhu/Id3tm2.1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Nlrc4tm1Vmd/Nlrc4tm1Vmd,Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: C57BL/6-Nlrp3tm1Vmd Nlrc4tm1Vmd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: involves: 129S6/SvEvTac

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrp5tm1Jfh/Lrp5+,Lrp6Gt(Ex187)Byg/Lrp6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc11a1s/Slc11a1s
Genetic Background: BALB/c

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc11a1s/Slc11a1s
Genetic Background: BALB/c

 MP:0002984 retina hypoplasia "less than normal number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80994]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Nlrc4tm1Vmd/Nlrc4tm1Vmd,Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic Background: C57BL/6-Nlrp3tm1Vmd Nlrc4tm1Vmd

 MP:0003424 premature neuronal precursor differentiation "earlier than normal transformation of neuronal precursor cells into neurons" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+,Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jag1Yo/Jag1+
Genetic Background: C3HeB/FeJ-Jag1Yo

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Id3tm2.1Zhu/Id3tm2.1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Id3tm2.1Zhu/Id3tm2.1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc11a1s/Slc11a1s
Genetic Background: BALB/c

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id3tm2.1Zhu/Id3tm2.1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id3tm2.1Zhu/Id3tm2.1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J

 MP:0008346 increased gamma-delta T cell number "greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Id3tm2.1Zhu/Id3tm2.1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J

Allelic Composition: Id3tm2.1Cmu/Id3tm2.1Cmu
Genetic Background: Not Specified

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0008879 submandibular gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in either of the large major salivary glands situated beneath the mandible" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id3tm2.1Zhu/Id3tm2.1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J

 MP:0008880 lacrimal gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0009429 decreased embryo weight "reduced weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0009772 abnormal retinal development "anomaly in any of the steps during embryogenesis that produce the nerve layer lining in the back of the eye which senses light, and creates impulses that travel through the optic nerve to the brain" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0010186 increased T follicular helper cell number "greater number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]
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Allelic Composition: Id3tm2.1Cmu/Id3tm2.1Cmu
Genetic Background: Not Specified

 MP:0010537 tumor regression "a decrease in tumor size from a formerly larger state and/or a decrease in the extent of tumors in the body" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0010835 increased CD4-positive, alpha-beta memory T cell number "increased number of CD4-positive, alpha-beta long-lived T cells with the phenotype CD45RO-positive and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000897, GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149]
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Allelic Composition: Id3tm2.1Zhu/Id3tm2.1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J

 MP:0010838 increased CD8-positive, alpha-beta memory T cell number "increased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000909, GO_REF:0000031, GOC:tfm, PMID:20146720]
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Allelic Composition: Id3tm2.1Zhu/Id3tm2.1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Id1tm3Bene/Id1tm3Bene,Id2tm1Xdz/Id2tm1Xdz,Id3tm1Zhu/Id3tm1Zhu,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0013367 parotid gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in either of the largest of the major salivary glands situated below and in front of each ear " [MGI:Anna]
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Allelic Composition: Id3tm2.1Zhu/Id3tm2.1Zhu,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL * SJL/J

 MP:0020220 decreased tear production "decreased production of the amount of fluid produced in the eye" [GOC:NV]
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Allelic Composition: Id1tm1Zhu/Id1tm1Zhu,Tcf3tm1Wein/Tcf3tm1Wein
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Id3tm1Zhu/Id3tm1Zhu
Genetic Background: B6.129S4-Id3tm1Zhu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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