ENSG00000115738


Homo sapiens

Features
Gene ID: ENSG00000115738
  
Biological name :ID2
  
Synonyms : ID2 / inhibitor of DNA binding 2 / Q02363
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p25.1
Gene start: 8678845
Gene end: 8684453
  
Corresponding Affymetrix probe sets: 201565_s_at (Human Genome U133 Plus 2.0 Array)   201566_x_at (Human Genome U133 Plus 2.0 Array)   213931_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000379585
Ensembl peptide - ENSP00000385465
Ensembl peptide - ENSP00000234091
NCBI entrez gene - 3398     See in Manteia.
OMIM - 600386
RefSeq - NM_002166
RefSeq Peptide - NP_002157
swissprot - Q02363
swissprot - Q53T66
Ensembl - ENSG00000115738
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 id2aENSDARG00000055283Danio rerio
 id2bENSDARG00000029544Danio rerio
 ID2ENSGALG00000035016Gallus gallus
 Id2ENSMUSG00000020644Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ID4 / P47928 / inhibitor of DNA binding 4, HLH proteinENSG0000017220144
ID1 / P41134 / inhibitor of DNA binding 1, HLH proteinENSG0000012596843
ID3 / Q02535 / inhibitor of DNA binding 3, HLH proteinENSG0000011731838


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR026052  DNA-binding protein inhibitor
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001656 metanephros development IEA
 biological_processGO:0001779 natural killer cell differentiation IEA
 biological_processGO:0001966 thigmotaxis IEA
 biological_processGO:0002521 leukocyte differentiation IEA
 biological_processGO:0003149 membranous septum morphogenesis IEA
 biological_processGO:0003166 bundle of His development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0009649 entrainment of circadian clock IEA
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0010629 negative regulation of gene expression ISS
 biological_processGO:0014003 oligodendrocyte development IEA
 biological_processGO:0019216 regulation of lipid metabolic process ISS
 biological_processGO:0021772 olfactory bulb development IEA
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0033598 mammary gland epithelial cell proliferation ISS
 biological_processGO:0042752 regulation of circadian rhythm ISS
 biological_processGO:0043153 entrainment of circadian clock by photoperiod ISS
 biological_processGO:0043353 enucleate erythrocyte differentiation IEA
 biological_processGO:0043392 negative regulation of DNA binding IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0045475 locomotor rhythm ISS
 biological_processGO:0045578 negative regulation of B cell differentiation IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IEA
 biological_processGO:0045651 positive regulation of macrophage differentiation IEA
 biological_processGO:0045665 negative regulation of neuron differentiation ISS
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045777 positive regulation of blood pressure ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0048468 cell development IEA
 biological_processGO:0048469 cell maturation IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048541 Peyer"s patch development IEA
 biological_processGO:0048557 embryonic digestive tract morphogenesis ISS
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation ISS
 biological_processGO:0048663 neuron fate commitment ISS
 biological_processGO:0048667 cell morphogenesis involved in neuron differentiation IEA
 biological_processGO:0048711 positive regulation of astrocyte differentiation IEA
 biological_processGO:0048715 negative regulation of oligodendrocyte differentiation IEA
 biological_processGO:0060612 adipose tissue development IEA
 biological_processGO:0060749 mammary gland alveolus development ISS
 biological_processGO:0061030 epithelial cell differentiation involved in mammary gland alveolus development ISS
 biological_processGO:0061031 endodermal digestive tract morphogenesis ISS
 biological_processGO:0071158 positive regulation of cell cycle arrest ISS
 biological_processGO:0071285 cellular response to lithium ion IEA
 biological_processGO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle IC
 biological_processGO:0090398 cellular senescence ISS
 biological_processGO:2000045 regulation of G1/S transition of mitotic cell cycle IMP
 biological_processGO:2000178 negative regulation of neural precursor cell proliferation ISS
 cellular_componentGO:0005634 nucleus IC
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0032991 protein-containing complex ISS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0044325 ion channel binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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