ENSG00000125968


Homo sapiens

Features
Gene ID: ENSG00000125968
  
Biological name :ID1
  
Synonyms : ID1 / inhibitor of DNA binding 1, HLH protein / P41134
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q11.21
Gene start: 31605283
Gene end: 31606515
  
Corresponding Affymetrix probe sets: 208937_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000365273
Ensembl peptide - ENSP00000365280
NCBI entrez gene - 3397     See in Manteia.
OMIM - 600349
RefSeq - NM_002165
RefSeq - NM_181353
RefSeq Peptide - NP_002156
RefSeq Peptide - NP_851998
swissprot - P41134
Ensembl - ENSG00000125968
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 id1ENSDARG00000040764Danio rerio
 ID1ENSGALG00000034661Gallus gallus
 Id1ENSMUSG00000042745Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ID2 / Q02363 / inhibitor of DNA binding 2ENSG0000011573837
ID4 / P47928 / inhibitor of DNA binding 4, HLH proteinENSG0000017220134
ID3 / Q02535 / inhibitor of DNA binding 3, HLH proteinENSG0000011731833


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR026052  DNA-binding protein inhibitor
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001525 angiogenesis TAS
 biological_processGO:0001886 endothelial cell morphogenesis IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0010621 negative regulation of transcription by transcription factor localization TAS
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032233 positive regulation of actin filament bundle assembly IEA
 biological_processGO:0032963 collagen metabolic process IEA
 biological_processGO:0036164 cell-abiotic substrate adhesion IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043392 negative regulation of DNA binding IEA
 biological_processGO:0043408 regulation of MAPK cascade IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0043534 blood vessel endothelial cell migration TAS
 biological_processGO:0045602 negative regulation of endothelial cell differentiation IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045765 regulation of angiogenesis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048514 blood vessel morphogenesis TAS
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0050774 negative regulation of dendrite morphogenesis IEA
 biological_processGO:0060425 lung morphogenesis IEA
 biological_processGO:0060426 lung vasculature development IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0090074 negative regulation of protein homodimerization activity IEA
 biological_processGO:1901342 regulation of vasculature development IEA
 biological_processGO:1901653 cellular response to peptide IEA
 biological_processGO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding IEA
 biological_processGO:1903351 cellular response to dopamine IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 cellular_componentGO:0005634 nucleus IC
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005813 centrosome IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043621 protein self-association IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0070628 proteasome binding IEA


Pathways (from Reactome)
Pathway description
Oncogene Induced Senescence


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000157557 ETS2 / P15036 / ETS proto-oncogene 2, transcription factor  / complex / reaction






 

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