ENSG00000157557


Homo sapiens

Features
Gene ID: ENSG00000157557
  
Biological name :ETS2
  
Synonyms : ETS2 / ETS proto-oncogene 2, transcription factor / P15036
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: 1
Band: q22.2
Gene start: 38805307
Gene end: 38824955
  
Corresponding Affymetrix probe sets: 201328_at (Human Genome U133 Plus 2.0 Array)   201329_s_at (Human Genome U133 Plus 2.0 Array)   241193_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000354194
Ensembl peptide - ENSP00000411086
Ensembl peptide - ENSP00000401273
Ensembl peptide - ENSP00000353344
NCBI entrez gene - 2114     See in Manteia.
OMIM - 164740
RefSeq - XM_005260935
RefSeq - XM_017028290
RefSeq - NM_001256295
RefSeq - NM_005239
RefSeq Peptide - NP_001243224
RefSeq Peptide - NP_005230
swissprot - P15036
swissprot - C9JAG2
swissprot - A0A0C4DG47
Ensembl - ENSG00000157557
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Ets2ENSMUSG00000022895Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ETS1 / P14921 / ETS proto-oncogene 1, transcription factorENSG0000013495452
ERG / P11308 / ERG, ETS transcription factorENSG0000015755428
GABPA / Q06546 / GA binding protein transcription factor alpha subunitENSG0000015472727
FLI1 / Q01543 / Fli-1 proto-oncogene, ETS transcription factorENSG0000015170227
ETV1 / P50549 / ETS variant 1ENSG0000000646822
ETV4 / P43268 / ETS variant 4ENSG0000017583221
ETV5 / P41161 / ETS variant 5ENSG0000024440520
ETV2 / O00321 / ETS variant 2ENSG0000010567219
FEV / Q99581 / FEV, ETS transcription factorENSG0000016349716
ERF / P50548 / ETS2 repressor factorENSG0000010572213
ETV3 / P41162 / ETS variant 3ENSG0000011703613
ETV3L / Q6ZN32 / ETS variant 3 likeENSG0000025383113
AC010616.1ENSG0000026804113
ELK1 / P19419 / ELK1, ETS transcription factorENSG0000012676712
ELK3 / P41970 / ELK3, ETS transcription factorENSG0000011114512
ELK4 / P28324 / ELK4, ETS transcription factorENSG0000015871111


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR003118  Pointed domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR016311  Transforming protein C-ets
 IPR027276  Transforming protein C-ets-2
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001501 skeletal system development TAS
 biological_processGO:0001712 ectodermal cell fate commitment IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007498 mesoderm development IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0090009 primitive streak formation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0035259 glucocorticoid receptor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Oncogene Induced Senescence


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction
 ENSG00000125968 ID1 / P41134 / inhibitor of DNA binding 1, HLH protein  / complex / reaction






 

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