ENSG00000154727


Homo sapiens

Features
Gene ID: ENSG00000154727
  
Biological name :GABPA
  
Synonyms : GA binding protein transcription factor alpha subunit / GABPA / Q06546
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: 1
Band: q21.3
Gene start: 25734570
Gene end: 25772460
  
Corresponding Affymetrix probe sets: 210188_at (Human Genome U133 Plus 2.0 Array)   227428_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000382948
Ensembl peptide - ENSP00000346886
NCBI entrez gene - 2551     See in Manteia.
OMIM - 600609
RefSeq - XM_017028313
RefSeq - NM_001197297
RefSeq - NM_002040
RefSeq - XM_005260938
RefSeq - XM_011529520
RefSeq - XM_011529521
RefSeq Peptide - NP_001184226
RefSeq Peptide - NP_002031
swissprot - A8IE48
swissprot - Q06546
Ensembl - ENSG00000154727
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gabpaENSDARG00000069289Danio rerio
 GABPAENSGALG00000015763Gallus gallus
 GabpaENSMUSG00000008976Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ETS2 / P15036 / ETS proto-oncogene 2, transcription factorENSG0000015755728
ETS1 / P14921 / ETS proto-oncogene 1, transcription factorENSG0000013495426
ERG / P11308 / ERG, ETS transcription factorENSG0000015755425
FLI1 / Q01543 / Fli-1 proto-oncogene, ETS transcription factorENSG0000015170224
ETV4 / P43268 / ETS variant 4ENSG0000017583219
ETV1 / P50549 / ETS variant 1ENSG0000000646817
ETV2 / O00321 / ETS variant 2ENSG0000010567217
ETV5 / P41161 / ETS variant 5ENSG0000024440516
FEV / Q99581 / FEV, ETS transcription factorENSG0000016349716
ETV3 / P41162 / ETS variant 3ENSG0000011703614
ELK3 / P41970 / ELK3, ETS transcription factorENSG0000011114513
AC010616.1ENSG0000026804113
ETV3L / Q6ZN32 / ETS variant 3 likeENSG0000025383113
ELK1 / P19419 / ELK1, ETS transcription factorENSG0000012676713
ERF / P50548 / ETS2 repressor factorENSG0000010572213
ELK4 / P28324 / ELK4, ETS transcription factorENSG0000015871112


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR003118  Pointed domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR016312  Transcription factor, GA-binding, alpha subunit
 IPR024668  GA-binding protein alpha subunit, N-terminal
 IPR029071  Ubiquitin-like domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0007005 mitochondrion organization TAS
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0045653 negative regulation of megakaryocyte differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:1903351 cellular response to dopamine IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0033613 activating transcription factor binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
Transcriptional activation of mitochondrial biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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